C. Suckling

发表

Lead optimisation efforts on a molecular prototype of the immunomodulatory parasitic protein ES-62

M. Harnett, W. Harnett, Joseph C. Oguegbulu, 2022, Physical Sciences Reviews.

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups.

C. Clements, A. Khalaf, C. Suckling, 2012, European journal of medicinal chemistry.

DNA sequence recognition by an isopropyl substituted thiazole polyamide.

Tom Brown, T. Brown, Keith R Fox, 2004, Nucleic acids research.

DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B).

Andrew J. Hampshire, T. Brown, R. Waigh, 2006, Bioorganic & medicinal chemistry letters.

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.

S. Pickett, C. Chung, C. Jamieson, 2016, Journal of medicinal chemistry.

Novel antibiotic mode of action by repression of promoter isomerisation

N. Tucker, I. Hunter, D. Browning, 2021, bioRxiv.

Approaches to chemically modified enzymes as synthetic catalysts

Limin Zhu, D. Aitken, C. Suckling, 1993 .

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.

S. Pickett, C. Chung, E. Nicodème, 2015, Journal of medicinal chemistry.

In situ detection of pterins by SERS.

R. Wadsworth, K. Faulds, D. Graham, 2009, The Analyst.

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

Fraser J. Scott, M. Harnett, W. Harnett, 2013, Journal of medicinal chemistry.

The synthesis of fluorine-containing pterins.

C. Suckling, C. Dunn, C. Gibson, 1997, Advances in experimental medicine and biology.

Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease

A. Cooke, M. Harnett, W. Harnett, 2018, Molecules.

The effects of 6-azacholest-4-en-3 beta-ol-7-one, an inhibitor of cholesterol 7 alpha-hydroxylase, on cholesterol metabolism and bile acid synthesis in primary cultures of rat hepatocytes.

K. Suckling, C. Suckling, K. Botham, 1988, Biochimica et biophysica acta.

Effects of novel synthetic sterol probes on enzymes of cholesterol metabolism in cell-free and cellular systems.

R. A. Harte, K. Suckling, S. Yeaman, 1996, Chemistry and physics of lipids.

The Synthesis of Haptens and Properties of Catalytic Antibodies Designed to Catalyse Carbanionic Cyclisation Reactions

Limin Zhu, C. Suckling, W. Stimson, 1995 .

Asymmetric reduction of dihydrofolate using dihydrofolate reductase and chiral boron-containing compounds

C. Suckling, E. Valente, H. Wood, 1986 .

A 1H spin echo NMR study of the HeLa tumour cell

I. Watson, W. E. Smith, J. Reglinski, 1987, FEBS letters.

Doxorubicin-induced altered glycolytic patterns in the leukemic cell studied by proton spin echo NMR.

W. Smith, I. Watson, J. Reglinski, 1988, Clinica chimica acta; international journal of clinical chemistry.

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

M. Harnett, W. Harnett, M. Pineda, 2015, Journal of autoimmunity.

Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis

M. Harnett, W. Harnett, J. Doonan, 2018, Front. Immunol..

Methyl 2-amino-5-isopropyl-1,3-thiazole-4-carboxylate

R. Waigh, A. Khalaf, C. Suckling, 2004 .

Host–guests binding by a simple detergent derivative: ‘tentacle molecules’

C. Suckling, 1982 .

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

M. Harnett, W. Harnett, A. Khalaf, 2014, International journal for parasitology.

Small Molecule Analogues of the parasitic worm product ES ┽ びは interact with the TIR domain of MyDふふ to inhibit pro ┽ in ━ ammatory signalling

M. A. Olson, M. Harnett, W. Harnett, 2018 .

Enzymes in organic synthesis

K. Suckling, C. Suckling, 1974 .

6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases.

S. Daff, R. Wadsworth, C. Gibson, 2008, Bioorganic & medicinal chemistry letters.

University of Dundee Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

M. Barrett, W. Hunter, C. Gibson, 2014 .

5α,6α-Methanocholestan-3 β-ol as a probe of the mechanism of action of cholesterol 7α-hydroxylase

K. Suckling, C. Suckling, L. Brown, 1986 .

Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds

S. Mackay, C. Clements, A. Khalaf, 2013, Medicinal Chemistry Research.

Failure of the anti-inflammatory parasitic product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory disease.

A. Cooke, M. Harnett, W. Harnett, 2019 .

Effects of 6,6-difluorocholestanol and 7,7-difluorocholestanol on hepatic enzymes of cholesterol metabolism.

K. Suckling, C. Suckling, B. Jackson, 1989, Biochimica et biophysica acta.

Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES‐62 against clinically relevant allergens

M. Harnett, W. Harnett, J. Doonan, 2016, Parasite immunology.

Enzyme Chemistry: Impact and applications

C. Suckling, 1990 .

Characteristics of the peptidase activity contained in Taiwan cobra (Naja naja atra) venom.

C. Suckling, M. Dufton, D. Boumrah, 1993, Toxicon : official journal of the International Society on Toxinology.

Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model.

M. Harnett, W. Harnett, J. Doonan, 2019, Molecular and biochemical parasitology.

The influence of α-trialkylsilyloxy groups on the rate of ring opening of cyclopropylmethyl radicals

J. Walton, C. Suckling, D. C. Nonhebel, 1983 .

The world is experiencing an obesity epidemic: over a third of the world’s adult

M. Harnett, W. Harnett, J. Doonan, 2019 .

The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing

M. Harnett, W. Harnett, J. Doonan, 2022, Frontiers in Immunology.

Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove.

N. Buurma, S. Mackay, M. Evstigneev, 2013, Biophysical chemistry.

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

J. Parkinson, C. Suckling, Fraser J Scott, 2013 .

Ranking ligand affinity for the DNA minor groove by experiment and simulation.

S. Mackay, S. Hannongbua, J. Parkinson, 2010, ACS medicinal chemistry letters.

Kevin M. Smith, Kevin M Smith, C. Suckling, 1976 .

Bicyclic 6-6 Systems: Pteridines

C. Gibson, C. Suckling, Judith K. Huggan, 2008 .

Tetramic acid and imidazolidinone syntheses via unexpected base induced cyclisations of alanine derived Weinreb amides

J. Parkinson, C. Gibson, C. Suckling, 2008 .

The synthesis of A- and B-ring fluorinated analogues of cholesterol

A. Pitt, K. Suckling, C. Suckling, 1999 .

Ethyl 5-oxo-2,5-dihydro-4-isoxazolecarboxylate hydroxylamine salt

R. Waigh, A. Khalaf, C. Suckling, 2003 .

Selective functionalisatlon: Part 10. The nitration of phenols by pyridine derivatives carrying a transferable nitro group

C. Suckling, H. Pervez, J. Rooney, 1988 .

Selective nitration of phenol

C. Suckling, H. Pervez, L. Rees, 1985 .

Solvent effects on biocatalysis in organic systems: Equilibrium position and rates of lipase catalyzed esterification

P. Halling, C. Suckling, R. Valivety, 1991, Biotechnology and bioengineering.

The Cyclopropyl Group in Studies of Enzyme Mechanism and Inhibition

C. Suckling, 1988 .

Mechanistic exploration of the palladium-catalyzed process for the synthesis of benzoxazoles and benzothiazoles.

John A. Murphy, C. Suckling, S. Lang, 2013, The Journal of organic chemistry.

A powerful palladium-catalyzed multicomponent process for the preparation of oxazolines and benzoxazoles.

John A. Murphy, C. Suckling, S. Lang, 2011, Organic letters.

Cyclopropylmethyl compounds as probes of the mechanism of hydrogen transfer by NAD(H) and alcohol dehydrogenase

S. Orszulik, C. Suckling, I. Macinnes, 1982 .

Solid and Solution Phase Strategies for the Synthesis of Potential Inhibitors of Folate Biosynthesis

C. Gibson, K. Ohta, C. Suckling, 2002 .

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

David M. Wilson, Melanie V. Leveridge, G. Drewes, 2016, Journal of medicinal chemistry.

Pyridinium salts and dihydropyridines; mechanistic studies of the redox reaction between pyridinium salts and alkoxides in tetrahydrofuran

C. Suckling, Alexander Shirra, 1977 .

Inhibition of [3H]GABA Binding to Postsynaptic Receptors in Human Cerebellar Synaptic Membranes by Carboxyl and Amino Derivatives of GABA

L. Iversen, C. Suckling, A. Nicol, 1981, Journal of neurochemistry.

Recognition of the DNA Minor Groove by Thiazotropsin Analogues

S. Mackay, J. Parkinson, A. Khalaf, 2014, Chembiochem : a European journal of chemical biology.

From multiply active natural product to candidate drug? Antibacterial (and other) minor groove binders for DNA.

C. Suckling, 2012, Future medicinal chemistry.

Synthesis of Novel Dna Binding Agents: Indole-Containing Analogues of Bis-Netropsin

A. Pitt, M. Scobie, R. Waigh, 2000 .

A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity.

S. Mackay, J. Parkinson, A. Khalaf, 2009, Organic & biomolecular chemistry.

A divergent synthesis of minor groove binders with tail group variation.

C. Suckling, A. Kennedy, David Breen, 2009, Organic & biomolecular chemistry.

Molecular recognition and physicochemical properties in the discovery of selective antibacterial minor groove binders

Colin J. Suckling, C. Suckling, 2008 .

Minor groove binders 1998 – 2004

C. Suckling, 2004 .

Synthesis and antimicrobial activity of some netropsin analogues.

S. Mackay, R. Waigh, A. Khalaf, 2004, Organic & biomolecular chemistry.

Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.

R. Waigh, A. Khalaf, C. Suckling, 2004, Journal of medicinal chemistry.

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.

W. Hunter, A. Harvey, Jeong Hwan Lee, 2009, Organic & biomolecular chemistry.

Ethyl 2-({6-amino-2-(benzylsulfanyl)-5-[2-(ethoxycarbonyl)prop-2-enyl]pyrimidin-4-yloxy}methyl)acrylate

C. Gibson, C. Suckling, A. Kennedy, 2006 .

A traceless solid-phase synthesis of pteridines

C. Gibson, C. Suckling, S. L. Rosa, 2003 .

Specific enzyme inhibitors in vitamin biosynthesis. Part 6. Identification of an affinity chromatography ligand for the purification of riboflavin synthase

R. Wrigglesworth, C. Suckling, H. Wood, 1984 .

Latent inhibitors. Part 7. Inhibition of dihydro-orotate dehydrogenase by spirocyclopropanobarbiturates

W. Fraser, C. Suckling, H. Wood, 1990 .

On the Specificity of Reactions Catalysed by the Antibody H11

A. Pitt, A. Khalaf, C. Suckling, 2000 .

Latent inhibitors. Part 5. Latent inhibition of dihydrofolate reductase by a pteridine-spiro-cyclopropane

C. Suckling, H. Wood, J. Haddow, 1989 .

Specific inhibitors in vitamin biosynthesis. Part 10. Synthesis of 7- and 8-substituted 7-deazaguanines

C. Gibson, K. Ohta, C. Suckling, 1998 .

Synthesis of potential inhibitors of GTP-cyclohydrolase I: anefficient synthesis of 8-substituted 7-deazaguanines

C. Gibson, C. Suckling, K. Paulini, 1997 .

Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A

S. Mackay, J. Parkinson, N. Wheate, 2012 .

Diversity oriented synthesis: substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines

C. Gibson, C. Suckling, Judith K. Huggan, 2011 .

Selectivity in synthesis — chemicals or enzymes?

C. Suckling, 1990 .

An unusual stable adduct in the reaction of pyruvate with papain Chemically modiied by 3-acetyl pyridinium and quinolinium derivatives

C. Suckling, Li-Min Zhu, L. Anderson, 1994 .

On the mechanism of hydrogen transfer by nicotinamide coenzymes and some dehydrogenases

D. Laurie, J. Walton, C. Suckling, 1986 .

A novel biotransformation of benzofurans and related compounds catalysed by a chloroperoxidase

I. Hunter, C. Suckling, Michael J. K. Thomas, 2001 .

Muscimol and some aza analogues: molecular orbital calculations relating to their potency as GABA mimetics.

D. Armstrong, C. Suckling, R. Breckenridge, 1982, Journal of theoretical biology.

Inhibition of neuronal GABA uptake and glial beta-alanine uptake by synthetic GABA analogues.

L. Iversen, C. Suckling, A. Nicol, 1981, Biochemical pharmacology.

GABA analogues: conformational analysis of effects on [3H]GABA binding to postsynaptic receptors in human cerebellum

L. Iversen, C. Suckling, L. Iversen, 1979, Journal of neurochemistry.

Latent inhibitors. Part 8. Synthesis and evaluation of some mechanism-based inhibitors of dihydrofolate reductase

C. Suckling, H. Wood, J. Mcgill, 1992 .

Selective functionalisation. Part 11. Selective hydrogenation by a novel palladium salicylidene-ethylenediamine complex and the properties of derivatives of some square planar homogeneous hydrogenation catalysts

P. Bamfield, C. Suckling, J. M. Kerr, 1990 .

Carbon-carbon bond formation mediated by papain chemically modified by thiazolium salts

C. Suckling, Li-Min Zhu, 1993 .

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Fraser J. Scott, G. Mayer, Christina E Lünse, 2014, Front. Chem..

Syntheses of highly functionalised 6-substituted pteridines.

C. Gibson, C. Suckling, D. Guiney, 2003, Organic & biomolecular chemistry.

The synthesis of some water insoluble dyes for the measurement of pH in water immiscible solvents

P. Halling, C. Suckling, R. Valivety, 2010 .

An investigation of the aggregation and water-air interfacial behaviour of a cationic tentacle molecule

D. Sherrington, C. Suckling, S. M. Hamid, 1986 .

A prototype solid phase synthesis of pteridines and related heterocyclic compounds.

Salvatore La Rosa, C. Gibson, C. Suckling, 2003, Organic & biomolecular chemistry.

Selective functionalisation-7

D. Sherrington, C. Suckling, D. Robinson, 1984 .

Redox reactions of pyridinium salts

C. Suckling, Alexander Shirra, 1975 .

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.

Fraser J. Scott, M. Barrett, H. D. de Koning, 2019, Journal of medicinal chemistry.

Selective functionalization. IX: The chlorination of phenol and some phenyl ethers by functionalized surfactants

C. Suckling, S. O. Onyiriuka, 1986 .

Selective functionalisation. Part 6. The chlorination of phenol in micellar solution

Alan A. Wilson, C. Suckling, S. O. Onyiriuka, 1983 .

High selectivity in the chlorination of phenol in the presence of functionalised micelles

C. Suckling, S. O. Onyiriuka, 1982 .

Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3

Fraser J. Scott, J. Sutton, S. Dancer, 2022, ACS infectious diseases.

Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification

Fraser J. Scott, A. Khalaf, C. Suckling, 2022, International journal of molecular sciences.

Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era

I. Hunter, C. Suckling, Fraser J Scott, 2022, Future drug discovery.

Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection

Fraser J. Scott, F. Brombacher, R. Guler, 2022, The Journal of antimicrobial chemotherapy.

Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

M. Barrett, A. Khalaf, C. Suckling, 2021, RSC medicinal chemistry.

The potential for new and resilient anti-cancer drugs based upon minor groove binders for DNA

C. Suckling, Fraser J Scott, 2021, Medical Research Archives.

Why Antibacterial Minor Groove Binders Are a Good Thing

N. Tucker, I. Hunter, A. Khalaf, 2017 .

An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics.

M. Barrett, F. Brombacher, R. Guler, 2017, European journal of medicinal chemistry.

Selective anti-malarial minor groove binders.

V. Avery, Sandra Duffy, A. Khalaf, 2016, Bioorganic & medicinal chemistry letters.

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

M. Barrett, V. Avery, Sandra Duffy, 2016, European journal of medicinal chemistry.

Minor groove binders as anti-infective agents.

M. Barrett, C. Gemmell, C. Suckling, 2013, Pharmacology & therapeutics.

Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.

Jean-Jacques Helesbeux, David Breen, S. Mackay, 2007, Journal of medicinal chemistry.

The Synthesis of Some Head to Head Linked DNA Minor Groove Binders

A. Pitt, M. Scobie, R. Waigh, 2000 .

The Cyclopropyl Group in Studies of Enzyme-Catalysed Reactions

C. Suckling, 1989 .

DNA binding of a short lexitropsin.

S. Mackay, J. Parkinson, B. Johnston, 2004, Bioorganic & medicinal chemistry letters.

Pyridoxal derivatives as probes for water concentration in non-aqueous solvents

P. Halling, C. Suckling, R. Valivety, 1993 .

Latent inhibitors. Part 2. Allylic inhibitors of alcohol dehydrogenase

R. Wrigglesworth, C. Suckling, I. Macinnes, 1981 .

Selective in vitro anti-cancer activity of non-alkylating minor groove binders.

R. Phillips, A. Khalaf, C. Suckling, 2019, MedChemComm.

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Fraser J. Scott, S. P. Parihar, F. Brombacher, 2017, The Journal of antimicrobial chemotherapy.

Comparison of DNA Complex Formation Behaviour for Two Closely Related Lexitropsin Analogues

S. Mackay, J. Parkinson, R. Waigh, 2009 .

A detailed binding free energy study of 2:1 ligand-DNA complex formation by experiment and simulation.

Supa Hannongbua, Guillaume Huchet, Kitiyaporn Wittayanarakul, 2009, Physical chemistry chemical physics : PCCP.

Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.

S. Mackay, J. Parkinson, B. Johnston, 2004, Journal of the American Chemical Society.

Amide isosteres in structure-activity studies of antibacterial minor groove binders.

S. Mackay, A. Khalaf, C. Suckling, 2011, European journal of medicinal chemistry.

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Murray N. Robertson, Murray N Robertson, A. Gray, 2017, Journal of medicinal chemistry.

An evaluation of Minor Groove Binders as anti-lung cancer therapeutics.

M. Grant, G. Westrop, D. Watson, 2016, Bioorganic & medicinal chemistry letters.

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.

B. Morris, J. Pratt, A. Harvey, 2007, Bioorganic & medicinal chemistry letters.

Minor groove binders substituted by lipophilic groups

Robert M. Williams, I. Hunter, J. Parkinson, 2003 .

Inhibition of carboxypeptidase by cyclopropane-containing peptides

R. Wrigglesworth, C. Suckling, A. Bell, 1987 .

Enzyme inhibition by electrophilic cyclopropane derivatives

C. Suckling, R. Breckenridge, 1986 .

Reactive intermediates in enzyme-catalysed reactions

C. Suckling, 1984 .

2-Cyclopropaneglyoxylic acid: a probe for the mechanism of hydrogen transfer by lactate dehydrogenase and by N-benzyl-1,4-dihydronicotinamide

S. Orszulik, C. Suckling, D. C. Nonhebel, 1982 .

Asymmetric Rhodium-Catalysed Addition of Arylboronic Acids to Acyclic Unsaturated Esters Containing a Basic γ-Amino Group

S. Macdonald, J. Pritchard, C. Suckling, 2012, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

Latent inhibitors. Part 3. The inhibition of lactate dehydrogenase and alcohol dehydrogenase by cyclopropane-containing compounds

R. Wrigglesworth, S. Orszulik, C. Suckling, 1984 .

ArticleThe synthesis of fluorine-containing pterins

C. Gibson, C. Suckling, C. Dunn, 1996 .

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.

Joelle Le, S. Macdonald, J. Pritchard, 2018, Journal of medicinal chemistry.

The diversity‐oriented synthesis of pteridines—achievements and potential for development

C. Suckling, 2013, IUBMB life.

Ring opening of oxiranylmethyl and 3-methyl-3-oxetanylmethyl radicals

D. Laurie, J. Walton, C. Suckling, 1993 .

Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles

R. Waigh, A. Khalaf, C. Suckling, 2000 .

Novel Reactivity of 2‐(Chloromethoxy)ethyl Acetate.

D. Aitken, C. Suckling, H. Wood, 1986 .

The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I

C. Gibson, K. Ohta, C. Suckling, 2004 .

A fluorine-19 and deuterium NMR study of two novel fluorosterols and their properties in model membranes and high density lipoprotein

K. Suckling, D. Reid, L. K. MacLachlan, 1991 .

Clean Synthesis as Environmentally Friendly Chemistry

C. Suckling, 1995 .

An antibody with dual catalytic activity

M. C. Tedford, C. Suckling, L. Bence, 1992 .

On the parameterization of rigid base and basepair models of DNA from molecular dynamics simulations

S. Harvey, T. Bishop, B. Devkota, 2009 .

Al-Riyami, Lamyaa and Rodgers, David T. and Rzepecka, Justyna and Pineda, Miguel A. and Suckling, Colin J. and Harnett, Margaret M. and Harnett, William (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-

M. Harnett, W. Harnett, M. Pineda, 2018 .

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

M. Harnett, W. Harnett, M. Pineda, 2015, Experimental parasitology.

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis.

Fraser J. Scott, M. Harnett, W. Harnett, 2018, Acta tropica.

Crystal structure of N,N-dimethyl-2-[(4-methylbenzyl)sulfonyl]ethanamine

Alan R. Kennedy, Abedawn I. Khalaf, Fraser J. Scott, 2015, Acta crystallographica. Section E, Crystallographic communications.

A modelling study of a non-concerted hydrolytic cycloaddition reaction by the catalytic antibody H11.

S. Mackay, R. Clark, B. Johnston, 2006, Bioorganic & medicinal chemistry.

The Creation of New Catalysts

C. Suckling, 2005 .

Catalytic Properties of the Antibody H11

A. Pitt, C. Suckling, J. J. Marrero-Tellado, 1996 .

Novel TPP-riboswitch activators bypass metabolic enzyme 1 dependency 2 3

Fraser J. Scott, G. Mayer, Christina E Lünse, 2018 .

Charles Walter Suckling. 24 July 1920—30 October 2013

C. Suckling, M. J. McCann, 2019, BIOGRAPHICAL MEMOIRS OF FELLOWS OF THE ROYAL SOCIETY.

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

P. Grandi, A. Michon, P. Bamborough, 2017, Journal of medicinal chemistry.

Mycobacterium tuberculosis Decaprenylphosphoryl-β-D-ribose Oxidase inhibitors: expeditious reconstruction of sub-optimal hits into a series with potent in vivo activity.

I. Wall, G. Burley, M. Cacho, 2020, Journal of medicinal chemistry.

Specific inhibitors in vitamin biosynthesis. Part 11. Syntheses of pterins with extended side chains at C-6

C. Gibson, K. Ohta, C. Suckling, 1999 .

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases†

Terry K. Smith, W. Hunter, Viviane Paula Martini, 2009, Journal of medicinal chemistry.

Specific enzyme inhibitors in vitamin biosynthesis. Part 3. The synthesis and inhibitory properties of some substrates and transition state analogues of riboflavin synthase

R. Ferone, R. Wrigglesworth, C. Suckling, 1980 .

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

M. Harnett, W. Harnett, Anuradha Tarafdar, 2021, PLoS pathogens.

Catalytic antibodies--a new window on protein chemistry.

C. Suckling, 1992, Biochemical Society transactions.

Catalytic antibodies: a new window on protein chemistry.

G. Proctor, A. Khalaf, C. Suckling, 1992, Ciba Foundation symposium.

Remarkably efficient hydrolysis of a 4-nitrophenyl ester by a catalytic antibody raised to an ammonium hapten

G. Proctor, A. Khalaf, C. Suckling, 1992 .

Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.

R. Prinjha, P. Soden, C. Chung, 2021, Journal of medicinal chemistry.

Chemical approaches to the discovery of new drugs.

C. Suckling, 1991, Science progress.

On the mechanism of action of GTP-transforming enzymes

A. Pitt, C. Gibson, C. Suckling, 1997 .

SPECIFIC ENZYME INHIBITORS IN VITAMIN BIOSYNTHESIS. PART 3. THE SYNTHESIS AND D INHIBITORY PROPERTIES OF SOME SUBSTRATES AND TRANSITION STATE ANALOGS OF RIBOFLAVIN SYNTHASE

R. Ferone, R. Wrigglesworth, C. Suckling, 1981 .

Latent Inhibitors. Part 7. Inhibition of Dihydroorotate Dehydrogenase by Spirocyclopropanobarbiturates.

W. Fraser, C. Suckling, H. Wood, 1991 .

Latent Inhibitors. Part 6. Inhibition of Dihydroorotate Dehydrogenase by Substituted 5‐Benzylhydantoins.

C. Suckling, H. Wood, C. Howie, 1991 .

Latent inhibitors. Part 6. Inhibition of dihydro-orotate dehydrogenase by substituted 5-benzylhydantoins

C. Suckling, H. Wood, C. Howie, 1990 .

Latent inhibitors. Part 4. Irreversible inhibition of dihydro-orotate dehydrogenase by hydantoins derived from amino acids

C. Suckling, H. Wood, I. G. Buntain, 1988 .

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product┸ ES┽びは

M. Harnett, W. Harnett, J. Doonan, 2018 .

Synthesis of Pteridines With C-2 And C-6 Functional Group Diversity

C. Gibson, C. Suckling, S. L. Rosa, 2002 .

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

M. Harnett, W. Harnett, C. Suckling, 2016, Scientific Reports.

DNA Minor Groove Binders

R. Waigh, A. Khalaf, C. Suckling, 2003 .

The use of 1H spin echo NMR and HPLC to confirm doxorubicin induced depletion of glutathione in the intact HeLa cell.

I. Watson, J. Reglinski, M. J. Stewart, 1988, British Journal of Cancer.

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

S. Mackay, O. Sutcliffe, Oliver B. Sutcliffe, 2011, Beilstein journal of organic chemistry.

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties.

R. Wadsworth, C. Gibson, P. Milliken, 2011, European Journal of Pharmacology.

Specific inhibitors in vitamin biosynthesis. Part 7. Syntheses of blocked 7,8-dihydropteridines viaα-amino ketones

C. Suckling, I. Stirling, A. Curran, 1985 .

Structural ultrafast dynamics of macromolecules : diffraction of free DNA and effect of hydration

S. Harvey, T. Bishop, B. Devkota, 2009 .

The antibacterial drug MGB-BP3: from discovery to clinical trial

C. Suckling, 2015 .

Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

A. Khalaf, C. Suckling, A. Kennedy, 2017, Acta crystallographica. Section E, Crystallographic communications.

Latent inhibitors part 11. The synthesis of 5-spirocyclopropyl dihydroorotic acid

S. Husbands, W. Fraser, C. Suckling, 1995 .

The Contribution of Chemical Science to the Development of Biosensors

C. Suckling, 1988 .

Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds

S. Mackay, C. Clements, A. Khalaf, 2014, Medicinal Chemistry Research.

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

M. Harnett, W. Harnett, C. Suckling, 2018, Scientific Reports.

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

M. Harnett, W. Harnett, M. Pineda, 2015, Lupus.

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

M. Harnett, W. Harnett, J. Doonan, 2017, Scientific Reports.

Ethyl 2-aminooxazole-5-carboxylate

R. Waigh, A. Khalaf, C. Suckling, 2001 .

DNA binding, solubility, and partitioning characteristics of extended lexitropsins.

A. Pitt, M. Scobie, R. Waigh, 2000, Journal of medicinal chemistry.

Latent inhibitors Part 10. The inhibition of carboxypeptidase a by tetrapeptide analogues based on 1-aminocyclopropane carboxylic acid

S. Husbands, C. Suckling, Christopher A. Suckling, 1994 .

Latent inhibitors. Part 9. Substrate activated time-dependent inhibition of carboxypeptidase A by aminocyclopropanecarboxylic acid derivatives and analogues

R. Wrigglesworth, M. C. Tedford, C. Suckling, 1993 .

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties.

R. Wadsworth, C. Gibson, P. Milliken, 2011, European journal of pharmacology.

From multiply active natural product to candidate drug? Antibacterial (and other) minor groove binders for DNA.

C. Suckling, 2012, Future medicinal chemistry.

Measurement of pH changes in an inaccessible aqueous phase during biocatalysis in organic media

P. Halling, R. M. Blanco, C. Suckling, 1990, Biotechnology Letters.

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

T. Poulos, Huiying Li, C. Gibson, 2014, Biochemistry.

Substrate activated time dependent inhibition of carboxypeptidase a by aminocyclopropane carboxylic acid derivatives and analogues

C. Suckling, A. Kemp, C. Tedford, 1991 .

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

A. Khalaf, C. Suckling, Federica Giordani, 2014, Journal of medicinal chemistry.

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases†

W. Hunter, Jong-Seop Lee, C. Gibson, 2009, Journal of medicinal chemistry.

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.

W. Hunter, Jeong Hwan Lee, C. Clements, 2009, Organic & biomolecular chemistry.

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Fraser J. Scott, Sandra Duffy, A. Khalaf, 2016, European journal of medicinal chemistry.

Molecular recognition — A universal molecular science?

C. Suckling, 1991, Experientia.

MptpB Inhibitor Improves the Action of Antibiotics against Mycobacterium tuberculosis and Nontuberculous Mycobacterium avium Infections

Fraser J. Scott, M. Gutierrez, C. Suckling, 2023, ACS infectious diseases.

Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-b]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

S. Mackay, Usama M. Ammar, C. Suckling, 2024, Molecules.