J. Kulagowski

发表

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

P D Leeson, J. Kemp, P. Leeson, 1997, Journal of medicinal chemistry.

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.

Jane R Kenny, Michael Siu, Deepak Sampath, 2012, Journal of medicinal chemistry.

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

P. Leeson, S. Freedman, S. Patel, 1999, Bioorganic & medicinal chemistry letters.

4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor

P. Leeson, S. Patel, R. Marwood, 1997 .

Revealed by Novel TYK2-Selective Inhibitors Activity in Human Cytokine Responses A Restricted Role for TYK2 Catalytic

Adam R. Johnson, N. Lewin-Koh, Lawren C. Wu, 2013 .

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

P. Leeson, I. Stansfield, M. Rowley, 1994, Journal of medicinal chemistry.

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1996, Journal of medicinal chemistry.

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.

Bohdan Waszkowycz, Jane R Kenny, Charles Eigenbrot, 2012, Journal of medicinal chemistry.

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Adam R. Johnson, Jun Liang, N. Lewin-Koh, 2013, The Journal of Immunology.

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.

Adam R. Johnson, H. Dyke, Rohan V Mendonca, 2013, Bioorganic & medicinal chemistry letters.

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Ignacio Aliagas, 2013, Journal of medicinal chemistry.

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Tian Jin, 2012, Journal of medicinal chemistry.

Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists.

P. Leeson, M. Rowley, A. Foster, 1995, European journal of pharmacology.

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.

Jane R Kenny, Philippe Bergeron, Charles Eigenbrot, 2012, Bioorganic & medicinal chemistry letters.

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.

Adam R. Johnson, Rohan V Mendonca, M. Ultsch, 2012, Bioorganic & medicinal chemistry letters.