V. Sepsova

发表

Acetylcholinesterase inhibitors used or tested in Alzheimers disease therapy; their passive diffusion through blood brain barrier: In vitro study

K. Kuča, J. Korábečný, F. Zemek, 2013 .

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.

Oscar M. Bautista-Aguilera, D. Jun, R. León, 2016, Journal of medicinal chemistry.

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

K. Kuča, D. Jun, M. Valko, 2016, Journal of inorganic biochemistry.

A resurrection of 7-MEOTA: a comparison with tacrine.

K. Kuča, D. Jun, K. Musílek, 2013, Current Alzheimer research.

Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.

K. Kuča, D. Jun, O. Soukup, 2015, General physiology and biophysics.

The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor.

K. Kuča, K. Musílek, O. Soukup, 2014, Physiological research.

Synthesis, Biological Assessment and Molecular Modeling of Racemic QuinoPyranoTacrines for Alzheimer's Disease Therapy

D. Jun, O. Soukup, Ignacio Moraleda, 2018 .

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

D. Jun, O. Soukup, Ignacio Moraleda, 2018, Journal of enzyme inhibition and medicinal chemistry.

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.

K. Kuča, O. Soukup, D. Fedunova, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

D. Kaping, K. Kuča, D. Jun, 2017, Molecules.

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

J. Klimeš, K. Kuča, J. Korábečný, 2014, Expert opinion on drug safety.

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

D. Kaping, K. Kuča, D. Jun, 2017, Molecules.

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease

K. Kuča, D. Jun, K. Musílek, 2016, ChemMedChem.

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

J. Kos, M. Bajda, B. Malawska, 2018, ACS chemical neuroscience.

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.

M. Bartolini, M. Bolognesi, K. Kuča, 2017, European journal of medicinal chemistry.

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

J. Pejchal, J. Kassa, J. Misík, 2017, Molecules.

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

K. Kuča, R. Doležal, B. Bennion, 2013, International journal of molecular sciences.

OXIMES AS INHIBITORS OF ACETYLHOLINESTERASE - A STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY

K. Kuča, B. Bennion, F. Zemek, 2011 .

The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman‐Poisoned Mice – A Comparison with Commonly Used Pyridostigmine

J. Korábečný, J. Kassa, V. Sepsova, 2014, Basic & Clinical Pharmacology & Toxicology.

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

M. Valis, K. Kuča, E. Novotná, 2018, Drug design, development and therapy.

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

K. Kuča, D. Jun, D. Maliňák, 2015, Journal of medicinal chemistry.

Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

K. Kuča, F. Zemek, V. Sepsova, 2013, International journal of molecular sciences.

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K305, K307) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

K. Musílek, J. Kassa, A. Horova, 2017 .

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

K. Kuča, D. Jun, D. Maliňák, 2015, Molecules.

Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

K. Kuča, D. Jun, O. Soukup, 2018, Current Alzheimer research.

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

K. Kuča, D. Řípová, E. Hrubá, 2014, European journal of medicinal chemistry.

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K920, K923) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

K. Musílek, J. Kassa, A. Horova, 2015 .

A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice

K. Musílek, J. Kassa, A. Horova, 2015, Basic & clinical pharmacology & toxicology.

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice

K. Musílek, J. Kassa, A. Horova, 2015, Toxicology Mechanisms and Methods.

A comparison of the reactivating and therapeutic efficacy of two novel oximes K378 and K458 with currently available oximes in rats and mice poisoned with sarin

J. Kassa, V. Sepsova, M. Tůmová, 2014 .

The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

K. Musílek, J. Kassa, A. Horova, 2014, Toxicology mechanisms and methods.

A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes, in sarin poisoned rats and mice

J. Kassa, J. Karasova, V. Sepsova, 2011 .

The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice.

J. Kassa, J. Karasova, V. Sepsova, 2011, Basic & clinical pharmacology & toxicology.

The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

K. Musílek, J. Kassa, A. Horova, 2013, Toxicology mechanisms and methods.