K. Hattori

发表

Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.

M. Sakurai, Y. Matsumura, M. Imanishi, 2008, Journal of medicinal chemistry.

Screening of Bacteriophages Producing Endo-N-Acetylneuraminidase

S. Iijima, K. Miyake, Y. Machida, 1997 .

Neuroprotective Effects of A Novel Poly (ADP-ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in vitro Model of Cell Death and in Mouse MPTP Model of Parkinson’s Disease

Yamamoto, A. Iwashita, Hirofumi, 2004 .

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP‐ribose) polymerase‐1/2 inhibitors

A. Iwashita, T. Kinoshita, N. Matsuoka, 2005, FEBS letters.

Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.

A. Tanaka, J. Seki, K. Hattori, 2005, Bioorganic & medicinal chemistry letters.

Structure and function of a novel coliphage-associated sialidase.

S. Iijima, K. Miyake, Y. Machida, 2000, FEMS microbiology letters.

A New Poly (ADP-ribose) Polymerase Inhibitor, 2-(4-chlorophenyl)-5-quinoxalinecarboxamide (FR261529), Ameliorates Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice

Junya, Mutoh, A. Iwashita, 2004 .

Asymmetric synthesis of FR165914: A novel β3-adrenergic agonist with a benzocycloheptene structure

T. Kinoshita, I. Nakanishi, K. Hattori, 1995 .

Highly selective and operationally simple synthesis of enantiomerically pure .beta.-amino esters via double stereodifferentiation

Hisashi Yamamoto, K. Hattori, M. Miyata, 1993 .

Asymmetric aza-Diels-Alder reaction : enantio- and diastereoselective reaction of imine mediated by chiral Lewis acid

Hisashi Yamamoto, K. Hattori, 1993 .

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.

A. Iwashita, T. Kinoshita, N. Matsuoka, 2006, Bioorganic & medicinal chemistry.

Asymmetric Aza-Diels-Alder reaction mediated by chiral boron reagent

Hisashi Yamamoto, Hisashi Yamamoto, Kouji Hattori, 1992 .

A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.

J. Seki, K. Hattori, K. Tsubaki, 2000, Bioorganic & Medicinal Chemistry Letters.

Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson's Disease

A. Iwashita, N. Matsuoka, K. Hattori, 2004, Journal of Pharmacology and Experimental Therapeutics.

Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.

A. Tanaka, J. Seki, K. Hattori, 2006, Bioorganic & medicinal chemistry letters.

A New Chiral BLA Promoter for Asymmetric Aza Diels-Alder and Aldol-Type Reactions of Imines

K. Ishihara, Hisashi Yamamoto, T. Tada, 1994 .

4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

A. Iwashita, N. Matsuoka, K. Hattori, 2005, Bioorganic & medicinal chemistry letters.

Asymmetric aza-Diels-Alder reaction catalyzed by boron reagent : effect of biphenol and binaphthol ligand

Hisashi Yamamoto, K. Hattori, 1993 .

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

Takayoshi Kinoshita, Kenji Murano, Yoshiyuki Kido, 2004, Journal of medicinal chemistry.

Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.

A. Iwashita, K. Hattori, Junya Ishida, 2007, Bioorganic & medicinal chemistry letters.

Practical preparation of α-hydroxy-β-amino ester units; Stereoselective synthesis of taxol side chain and norstatine

Hisashi Yamamoto, K. Hattori, K. Hattori*, 1994 .

Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1′-substituted analogs

T. Kamimura, K. Hattori, T. Chiba, 1996 .

Novel asymmetric synthesis of β-lactams with 3-(1′-hydroxyethyl) substituents: boron reagent mediated aldol reaction of chiral imines and silyl ketene acetals derived from 3-hydroxybutyrate

Hisashi Yamamoto, K. Hattori, 1993 .

Highly selective generation and application of (E)- and (Z)-silyl ketene acetals from .alpha.-hydroxy esters

Hisashi Yamamoto, K. Hattori, 1993 .

Highly selective enolization method for heteroatom substituted esters; its application to the ireland ester enolate claisen rearrangement

Hisashi Yamamoto, K. Hattori, 1994 .

Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

A New Poly(ADP-Ribose) Polymerase Inhibitor, FR261529 [2-(4-Chlorophenyl)-5-quinoxalinecarboxamide], Ameliorates Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice

A. Iwashita, N. Matsuoka, K. Hattori, 2004, Journal of Pharmacology and Experimental Therapeutics.

A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia

A. Iwashita, N. Matsuoka, K. Hattori, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.

Nobuhiro Yamamoto, Minoru Sakurai, Yutaka Nakajima, 2008, Bioorganic & medicinal chemistry letters.

Inhibitor‐induced structural change of the active site of human poly(ADP‐ribose) polymerase

Takayoshi Kinoshita, Yoshiyuki Kido, A. Iwashita, 2004, FEBS letters.

Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.

M. Sakurai, Y. Matsumura, M. Imanishi, 2009, Journal of medicinal chemistry.

Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.

M. Sakurai, Y. Matsumura, M. Imanishi, 2008, Journal of medicinal chemistry.

Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.

M. Sakurai, Y. Matsumura, M. Imanishi, 2008, Journal of medicinal chemistry.

Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.

J. Seki, K. Hattori, S. Koyama, 2005, Bioorganic & medicinal chemistry letters.

A simple stereoselective synthesis and biological evaluation of FR181157: orally active prostacyclin mimetic.

K. Hattori, O. Okitsu, S. Tabuchi, 2003, Bioorganic & medicinal chemistry letters.

Characterization of a Multidomain Cellulase from an Extremely Thermophilic Anaerobe Strain NA10

S. Iijima, K. Miyake, Y. Machida, 1998 .

A New Chiral BLA Promoter for Asymmetric Aza Diels‐Alder and Aldol‐ Type Reactions of Imines.

K. Ishihara, Hisashi Yamamoto, T. Tada, 1995 .