E. Vieira

发表

Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

F. Winkler, A. D'arcy, C. Oefner, 1999, Chemistry & biology.

Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.

C. Oefner, A. Binggeli, H. Märki, 1999, Bioorganic & medicinal chemistry letters.

Piperidine-renin inhibitors compounds with improved physicochemical properties.

M. Kansy, C. Oefner, A. Binggeli, 1999, Bioorganic & medicinal chemistry letters.

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

J. Kemp, J. Kew, P. Malherbe, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

W. Guba, B. Kuhn, W. Spooren, 2007, Bioorganic & medicinal chemistry letters.

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Jens-Uwe Peters, Richard H. P. Porter, W. Spooren, 2005, Journal of Pharmacology and Experimental Therapeutics.

Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.

W. Spooren, J. Peters, S. Ceccarelli, 2007, Bioorganic & medicinal chemistry letters.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

W. Spooren, J. Peters, S. Ceccarelli, 2006, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

W. Guba, W. Spooren, J. Peters, 2015, Journal of medicinal chemistry.

A Ren in Inhibitor With Increasing Effects on Chronic Treatment

S. Mathews, V. Breu, W. Wostl, 2005 .

Metabolite Identification via LC‐SPE‐NMR‐MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

W. Spooren, J. Peters, S. Ceccarelli, 2008, ChemMedChem.

Piperidine renin inhibitors: from leads to drug candidates.

T Hartung, F C Luft, M. Kansy, 2001, Farmaco.

The Preparation of Optically Pure 7-Oxabicyclo[2.2.1]Hept-2-Ene Derivatives - the Cd Spectrum of (+)-(1r)-7-Oxabicyclo[2.2.1]Hept-5-En-2-One

P. Vogel, E. Vieira, 1983 .

Copper(I)‐ and Copper(II)‐catalyzed Diels‐Alder Additions of α‐Substituted Acrylonitrile to Furan. The Synthesis of 7‐Oxa‐bicyclo[2.2.1]hept‐5‐en‐2‐one

P. Vogel, E. Vieira, 1982 .

Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors.

T. Woltering, K. Bleicher, V. Mutel, 2002, Farmaco.

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.

V. Mutel, F. Knoflach, J. Huwyler, 2005, Bioorganic & medicinal chemistry letters.

Enantiomerically Pure 7-Oxabicyclo[2.2.1]Hept-5-En-2-Yl Derivatives as Synthetic Intermediates .3. Total Synthesis of D-Ribose and L-Ribose Derivatives

P. Vogel, E. Vieira, J. Wagner, 1988 .

Synthesis of (−)‐Conduritol C (1L‐Cyclohex‐5‐ene‐1,2,3/4‐tetrol)

P. Vogel, E. Vieira, C. L. Drian, 1989 .

COPPER(I)‐ AND COPPER(II)‐CATALYZED DIELS‐ALDER ADDITIONS OF α‐SUBSTITUTED ACRYLONITRILE TO FURAN. THE SYNTHESIS OF 7‐OXABICYCLO(2.2.1)HEPT‐5‐EN‐2‐ONE

P. Vogel, E. Vieira, 1983 .

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.

V. Mutel, F. Knoflach, J. Huwyler, 2009, Bioorganic & medicinal chemistry letters.

The utilization of purines in the biosynthesis of folic acid.

E. Vieira, E. Shaw, 1961, The Journal of biological chemistry.

CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor

W. Spooren, T. Hartung, Aubin Michalon, 2011, Journal of Pharmacology and Experimental Therapeutics.

Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression

Stephen R. Morairty, A. Bruns, W. Spooren, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Ciprokiren (Ro 44-9375). A renin inhibitor with increasing effects on chronic treatment.

S. Mathews, V. Breu, W. Wostl, 1994, Hypertension.

Pharmacology of Basimglurant ( RO 4917523 , RG 7090 ) , a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression s

Stephen R. Morairty, A. Bruns, W. Spooren, 2015 .

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

W. Spooren, J. Peters, S. Ceccarelli, 2006, Bioorganic & medicinal chemistry letters.

THE HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY OF SULFATED TETRASACCHARIDES IS SENSITIVE TO STRUCTURAL VARIATION

H. Wessel, T. Tschopp, E. Vieira, 1995 .

Asymmetric Synthesis of 2-(α-Aminoalkyl)oxazoles, 2-Oxazolylpyrrolidines, 2-Oxazolylpiperidines: Total Synthesis of 4,5-Dihydroxypipecolinic Acid

J. Liebscher, E. Vieira, M. Thieme, 2000 .

Microsoft Word-Revised CTEP-Text Body_05-08-2011_final

W. Spooren, T. Hartung, Aubin Michalon, 2011 .

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

J. Kemp, J. Kew, P. Malherbe, 2001, Proceedings of the National Academy of Sciences of the United States of America.