P. O'shea

发表

Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension

E. Corley, Louis-Charles Campeau, D. Gauvreau, 2011 .

A Concise Synthesis of ( S )-?-Fluoroleucine Ethyl Ester

I. Davies, F. Gosselin, R. Volante, 2006 .

Selective metal-halogen exchange of 4,4′-dibromobiphenyl mediated by lithium tributylmagnesiate

I. Davies, F. Gosselin, S. Dolman, 2006 .

Convergent, Fit-For-Purpose, Kilogram-Scale Synthesis of a 5-Lipoxygenase Inhibitor

I. Davies, G. Hughes, Louis-Charles Campeau, 2012 .

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

M. Crackower, D. Denis, R. Stocco, 2011, Bioorganic & medicinal chemistry letters.

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.

L. Tan, E. Grabowski, Cheng-yi Chen, 2005, The Journal of organic chemistry.

Practical enantioselective synthesis of a COX-2 specific inhibitor

L. Tan, P. Reider, E. Grabowski, 2002 .

8π-Six-atom rings: 1,3,4,5-oxa- and -thia-triazines and 1,2,3,5-tetrazines from an extended tandem reaction: reactions of 1,2,3-triazolium-1-imides with (E)-cinnamaldehyde, methyl cyanodithioformate, and aryl-N-sulphinylamines: new tetrahydro-oxazolo[4,5-d]-1,2,3-triazoliumides and triazaspiro-[4.4]

R. N. Butler, D. Cunningham, P. McArdle, 1990 .

Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245

Paul Fernandez, G. Hughes, M. Girardin, 2011 .

Practical synthesis of a potent bradykinin B(1) antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide.

F. Gosselin, G. Hughes, D. Gauvreau, 2009, The Journal of organic chemistry.

A practical enantioselective synthesis of odanacatib, a potent Cathepsin K inhibitor, via triflate displacement of an alpha-trifluoromethylbenzyl triflate.

F. Gosselin, G. Hughes, R. Volante, 2009, The Journal of organic chemistry.

Selective monolithiation of 2,5-dibromopyridine with butyllithium

P. Reider, E. Grabowski, R. Tillyer, 2000 .

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

A. Bernardi, S. Ouellet, P. O'shea, 2009 .

Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles

F. Gosselin, E. Grabowski, R. Tillyer, 2006 .

Regioselective SNAr Reactions of Substituted Difluorobenzene Derivatives: Practical Synthesis of Fluoroaryl Ethers and Substituted Resorcinols.

A. Bernardi, S. Ouellet, P. O'shea, 2009 .

Enantioselective hydrogenation of N-H imines.

I. Davies, F. Gosselin, Xumu Zhang, 2009, Journal of the American Chemical Society.

A practical synthesis of 5-lipoxygenase inhibitor MK-0633.

I. Davies, F. Gosselin, M. Palucki, 2010, The Journal of organic chemistry.

Superior reactivity of thiosemicarbazides in the synthesis of 2-amino-1,3,4-oxadiazoles.

I. Davies, F. Gosselin, S. Dolman, 2006, The Journal of organic chemistry.

A Practical Synthesis of α-Aryl Methyl Ketones via a Transition-Metal-Free Meerwein Arylation

I. Davies, F. Gosselin, J. Mowat, 2007 .

Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.

F. Gosselin, D. Mathre, Cheng-yi Chen, 2004, Organic letters.

A Robust Kilo-Scale Synthesis of Doravirine

Wei Zhang, Qinghao Chen, Kevin M. Belyk, 2016 .

Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1

F. Gosselin, P. O'shea, W. Nack, 2020 .

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers.

F. Gosselin, P. O'shea, W. Nack, 2019, Organic letters.

Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles.

F. Gosselin, E. Grabowski, R. Tillyer, 2007 .

Practical synthesis of a renin inhibitor via a diastereoselective Dieckmann cyclization.

Bing Yu, I. Davies, G. Hughes, 2010, Organic letters.

Scalable synthesis of a prostaglandin EP4 receptor antagonist.

I. Davies, G. Hughes, D. Gauvreau, 2010, The Journal of organic chemistry.

Highly asymmetric dihydroxylation of 1-aryl-1′-pyridyl alkenes

Matthew L. Maddess, M. Zak, P. Reider, 2000 .

Unprecedented catalytic asymmetric reduction of N-H imines.

F. Gosselin, R. Volante, Cheng-yi Chen, 2005, Organic letters.

A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285.

I. Davies, F. Gosselin, P. O'shea, 2009, The Journal of organic chemistry.

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α‐Amino Esters

Paul N. Devine, J. R. Naber, G. Hughes, 2007 .

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Paul N. Devine, Louis-Charles Campeau, Paul D. O’Shea, 2013 .

CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development.

Stephen Lau, Danny Gauvreau, D. Gauvreau, 2012, The Journal of organic chemistry.

Preparative scale synthesis of the biaryl core of anacetrapib via a ruthenium-catalyzed direct arylation reaction: unexpected effect of solvent impurity on the arylation reaction.

I. Davies, A. Roy, S. Ouellet, 2011, The Journal of organic chemistry.

Oxazolidine Ring Opening and Isomerization to (E)-Imines. Asymmetric Synthesis of Aryl-α-fluoroalkyl Amino Alcohols.

F. Gosselin, R. Volante, Cheng-yi Chen, 2004 .

Oxazolidine ring opening and isomerization to (E)-imines. Asymmetric synthesis of aryl-alpha-fluoroalkyl amino alcohols.

F. Gosselin, R. Volante, Cheng-yi Chen, 2004, Organic letters.

Chemoselective Staudinger Strategyin the Practical, Fit for Purpose, Gram-Scale Synthesisof an HCV RNA Polymerase Inhibitor

Louis-Charles Campeau, P. O'shea, 2011 .

Nucleophilic displacements of non-racemic α-trifluoromethyl benzylic triflates

G. Hughes, D. Gauvreau, P. O'shea, 2009 .

Practical asymmetric synthesis of a potent Cathepsin K inhibitor. Efficient palladium removal following Suzuki coupling.

P. Prasit, R. Oballa, E. Grabowski, 2003, The Journal of organic chemistry.

Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor.

F. Gosselin, Cheng-yi Chen, A. Roy, 2006, The Journal of organic chemistry.

Magnesiation of electron-rich aryl bromides and their use in nickel-catalyzed cross-coupling reactions.

I. Davies, G. Hughes, P. O'shea, 2007, Organic letters.

Modeling a Crowdsourced Definition of Molecular Complexity

Robert P. Sheridan, Edward C. Sherer, Charlie Chang, 2014, J. Chem. Inf. Model..

A practical synthesis of renin inhibitor MK-1597 (ACT-178882) via catalytic enantioselective hydrogenation and epimerization of piperidine intermediate.

Stefan Abele, E. Corley, A. Roy, 2011, The Journal of organic chemistry.

Asymmetric Organozincate Additions to Ethyl 2,2,2-Trifluoropyruvate

F. Gosselin, J. Mowat, P. O'shea, 2007 .