P. Flaherty

发表

Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.

R. Bentley, C. Doe, Suresh B. Singh, 2011, Bioorganic & medicinal chemistry letters.

Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway.

P. Flaherty, I. Chopra, Prashi Jain, 2010, Bioorganic & medicinal chemistry letters.

The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal–hippocampal cholinergic tract

D. Johnson, N. Fitz, R. Gibbs, 2012, Neurobiology of Learning and Memory.

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling

Jane E. Cavanaugh, M. Burow, L. Miele, 2021, Biomolecules.

Diaminopropanols inhibiteurs de rénine

Wei Zhao, Salvacion T Cacatian, P. Flaherty, 2007 .

Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the SRN1 Mechanism

J. F. Wolfe, J. S. Pisipati, P. Flaherty, 1997 .

Crystal structure of tert-butyl 4-[4-(4-fluorophenyl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate

Mohit Gupta, P. Flaherty, Ashwini Gumireddy, 2021, Acta crystallographica. Section E, Crystallographic communications.

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

Laurent Meijer, Jeffry D Madura, L. Meijer, 2011, Bioorganic & medicinal chemistry.

Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.

J. F. Wolfe, A. Manheim, P. Flaherty, 1996, Journal of medicinal chemistry.

Short and efficient chiral pool and RCM approach towards the synthesis of the macrocyclic core of the salicylihalamides

G. Georg, P. Flaherty, C. Mossman, 2001 .

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione

P. Wipf, J. Brodsky, R. Leak, 2017, Molecular Pharmacology.

MEK 5-ERK 5 Signaling in Cancer : Implications for Targeted Therapy

Jane E. Cavanaugh, M. Burow, V. Hoang, 2018 .

Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer

Jane E. Cavanaugh, M. Burow, Mohit Gupta, 2019, Front. Oncol..

Diaminoalcane inhibiteurs de la protease aspartique

J. Wery, Wei Zhao, P. Flaherty, 2005 .

Identification of HIV inhibitors guided by free energy perturbation calculations.

Orlando Acevedo, O. Acevedo, Z. Ambrose, 2012, Current pharmaceutical design.

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

Jane E. Cavanaugh, M. Burow, L. Miele, 2021, Translational oncology.

Structure activity relationships of anthranilic acid-based compounds on cellular and in vivo mitogen activated protein kinase-5 signaling pathways.

J. Madura, Jane E. Cavanaugh, M. Burow, 2018, Bioorganic & medicinal chemistry letters.

Oncogenic signaling of MEK5-ERK5.

Jane E. Cavanaugh, M. Burow, B. Beckman, 2017, Cancer letters.

ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer

K. Nephew, L. Del Valle, Jane E. Cavanaugh, 2020, Frontiers in Oncology.

1-Isopropyl-4-nitro-6-methoxy-1H-benzimidazole

P. Flaherty, Prashi Jain, Michael D. Moore, 2008, Acta crystallographica. Section E, Structure reports online.

Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer

K. Nephew, D. Rusch, Jane E. Cavanaugh, 2021, Oncoscience.

Dual inhibition of MEK1/2 and MEK5 suppresses the EMT/migration axis in triple‐negative breast cancer through FRA‐1 regulation

K. Nephew, D. Rusch, D. Chrisey, 2021, Journal of cellular biochemistry.

Peptidyl Prolyl Isomerase Inhibitors

P. Flaherty, Prashi Jain, 2011 .

MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types.

D. Drewry, Jane E. Cavanaugh, B. Collins-Burow, 2022, Frontiers in bioscience.

Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread—Identification of a Promising Novel therapeutic target1

G. Feldmann, P. Brossart, P. Flaherty, 2015, Translational oncology.

A-ring ortho-disubstituted aporphine derivatives as potential agonists or antagonists at serotonergic 5-HT1A receptors.

J. P. Long, J. Cannon, P. Flaherty, 1995, Journal of Medicinal Chemistry.

Pharmacological inhibition of the MEK5/ERK5 and PI3K/Akt signaling pathways synergistically reduces viability in triple‐negative breast cancer

Jane E. Cavanaugh, M. Burow, Mohit Gupta, 2020, Journal of cellular biochemistry.

Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway.

P. Flaherty, I. Chopra, Prashi Jain, 2010, Bioorganic & medicinal chemistry.

Structure activity relationships of anthranilic acid-based compounds on cellular and in vivo mitogen activated protein kinase-5 signaling pathways.

J. Madura, Jane E. Cavanaugh, M. Burow, 2018, Bioorganic & medicinal chemistry letters.

NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

D. Drewry, Jane E. Cavanaugh, B. Collins-Burow, 2023, Cancers.