R. Luciani

发表

Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case

Francesca Spyrakis, Maria Paola Costi, Gabriele Cruciani, 2016, ChemMedChem.

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.

Maria Paola Costi, F. Esposito, R. Baruchello, 2018, Bioorganic & medicinal chemistry letters.

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

A. Cavalli, P. Michels, V. Hannaert, 2012, Journal of medicinal chemistry.

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Molecules.

Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.

Maria Paola Costi, S. Piras, P. Corona, 2009, European journal of pharmacology.

Multitarget, Selective Compound Design Yields Picomolar Inhibitors of a Kinetoplastid Pteridine Reductase 1

Maria Paola Costi, R. Wade, S. Gul, 2020 .

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Maria Paola Costi, R. Stroud, S. Mangani, 2012, Acta crystallographica. Section D, Biological crystallography.

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

Maria Paola Costi, G. Ponterini, P. Linciano, 2019, Molecules.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.

Maria Paola Costi, M. Mor, G. Ponterini, 2018, Journal of medicinal chemistry.

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

Maria Paola Costi, E. Novellino, W. Hunter, 2015, Journal of medicinal chemistry.

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

Maria Paola Costi, D. Piomelli, T. Bandiera, 2013, Scientific Reports.

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.

Maria Paola Costi, S. Gul, L. Costantino, 2018, European journal of medicinal chemistry.

SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent.

Maria Paola Costi, S. Gul, G. Ponterini, 2019, ACS medicinal chemistry letters.

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.

Maria Paola Costi, I. Briguglio, S. Piras, 2014, European journal of medicinal chemistry.

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.

Maria Paola Costi, S. Gul, G. Ponterini, 2019, European journal of medicinal chemistry.

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

Maria Paola Costi, R. Wade, Domantas Motiejūnas, 2011, Journal of medicinal chemistry.

Feasibility Study on a Measurement Method and a Portable Measuring System to Estimate the Concentration of Cloxacillin and β-Lactamase in Milk

Luigi Rovati, Stefano Cattini, Luca Ferrari, 2017, J. Sensors.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Maria Paola Costi, R. Wade, S. Gul, 2016, Journal of medicinal chemistry.

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.

Maria Paola Costi, S. Cole, L. Chiarelli, 2015, ACS chemical biology.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Maria Paola Costi, Ulrike Wittig, S. Gul, 2019, Journal of medicinal chemistry.

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Maria Paola Costi, R. Wade, S. Gul, 2022, Journal of medicinal chemistry.

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.

Maria Paola Costi, S. Mangani, L. Cancian, 2011, Journal of medicinal chemistry.

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.

Maria Paola Costi, T. Blundell, G. Ponterini, 2016, Journal of medicinal chemistry.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Maria Paola Costi, R. Wade, W. Hunter, 2017, ACS omega.

Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Maria Paola Costi, Daniela Cardinale, Giambattista Guaitoli, 2011, Proceedings of the National Academy of Sciences.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

S. Mangani, A. Catalano, C. Pozzi, 2016, European journal of medicinal chemistry.

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.

Maria Paola Costi, R. Stroud, J. Finer-Moore, 2012, Journal of medicinal chemistry.

Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.

Maria Paola Costi, Giambattista Guaitoli, Gabriele Cruciani, 2010, Bioorganic & medicinal chemistry.

Microbiota of sliced cooked ham packaged in modified atmosphere throughout the shelf life: Microbiota of sliced cooked ham in MAP.

S. Raimondi, G. Foca, A. Ulrici, 2019, International journal of food microbiology.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology

Maria Paola Costi, G. Ponterini, R. Guerrini, 2016, Scientific Reports.

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Maria Paola Costi, S. Mangani, L. Costantino, 2013, Journal of medicinal chemistry.

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Maria Paola Costi, F. Spyrakis, S. Mangani, 2021, Pharmaceuticals.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

E. Giovannetti, G. Peters, R. Wade, 2022, eLife.

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Molecules.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.

Maria Paola Costi, S. Piras, P. Corona, 2009, European journal of pharmacology.

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Maria Paola Costi, R. Stroud, S. Mangani, 2012, Acta crystallographica. Section D, Biological crystallography.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

S. Mangani, M. Costi, P. Linciano, 2023, European journal of medicinal chemistry.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Ulrike Wittig, S. Mangani, V. Hannaert, 2017, ACS omega.

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

A. Cavalli, P. Michels, V. Hannaert, 2012, Journal of medicinal chemistry.

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Kimberley M. Zorn, Daniel H. Foil, S. Ekins, 2023, Journal of medicinal chemistry.