S. Ferrari

Maria Paola Costi, G. Ponterini, Y. G. Assaraf, 2015, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Homodimeric enzymes as drug targets.

Maria Paola Costi, R. Wade, G. Cruciani, 2010, Current medicinal chemistry.

Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Maria Paola Costi, F. Magni, E. Braicu, 2018, Front. Pharmacol..

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

Maria Paola Costi, R. Wade, M. Bolognesi, 2019, SLAS discovery : advancing life sciences R & D.

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Maria Paola Costi, R. Stroud, S. Mangani, 2012, Acta crystallographica. Section D, Biological crystallography.

A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells

Maria Paola Costi, G. Ponterini, E. Leo, 2020, International journal of molecular sciences.

Aza-boronic acids as non-β-lactam inhibitors of AmpC-β-lactamase ☆

Maria Paola Costi, J. Blázquez, S. Ferrari, 2004 .

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

Maria Paola Costi, R. Wade, S. Gul, 2017, Molecules.

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.

Maria Paola Costi, A. Cavalli, M. Bolognesi, 2020, European journal of medicinal chemistry.

Intrinsic Fluorometric Reporters of Pteridine Reductase 1, a Target for Antiparasitic Agents

Maria Paola Costi, G. Ponterini, S. Ferrari, 2022, Physchem.

Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

Maria Paola Costi, R. Wade, S. Franchini, 2010, Protein engineering, design & selection : PEDS.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.

Maria Paola Costi, M. Mor, G. Ponterini, 2018, Journal of medicinal chemistry.

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.

J. Krucinski, R. Stroud, A. Anderson, 2005, Acta crystallographica. Section D, Biological crystallography.

Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.

Maria Paola Costi, M. G. Monti, C. Frassineti, 2013, International journal of oncology.

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.

Maria Paola Costi, S. Gul, L. Costantino, 2018, European journal of medicinal chemistry.

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment.

Maria Paola Costi, M. Bolognesi, M. Mor, 2015, Journal of medicinal chemistry.

SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent.

Maria Paola Costi, S. Gul, G. Ponterini, 2019, ACS medicinal chemistry letters.

2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.

Maria Paola Costi, I. Briguglio, S. Piras, 2014, European journal of medicinal chemistry.

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.

Maria Paola Costi, P. Corona, S. Ferrari, 2008, European journal of medicinal chemistry.

Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents

Maria Paola Costi, S. Piras, A. Carta, 2006 .

Antibacterial agent discovery using thymidylate synthase biolibrary screening.

Maria Paola Costi, F. Reniero, C. Guillou, 2006, Journal of medicinal chemistry.

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.

Maria Paola Costi, S. Gul, G. Ponterini, 2019, European journal of medicinal chemistry.

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

Maria Paola Costi, M. Bolognesi, M. Mor, 2022, Pharmaceutics.

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

Maria Paola Costi, R. Wade, Domantas Motiejūnas, 2011, Journal of medicinal chemistry.

Scaffolds and Biological Targets Avenue to Fight Against Drug Resistance in Leishmaniasis

Maria Paola Costi, N. Santarém, A. Cordeiro-da-Silva, 2018 .

An alternative method to isoenzyme profile for cell line identification and interspecies cross-contaminations: cytochrome b PCR-RLFP analysis

S. Ferrari, R. Villa, M. Ferrari, 2008, In Vitro Cellular & Developmental Biology - Animal.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Maria Paola Costi, R. Wade, S. Gul, 2016, Journal of medicinal chemistry.

Thymidylate synthase structure, function and implication in drug discovery.

Maria Paola Costi, D. Barlocco, D Barlocco, 2005, Current medicinal chemistry.

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.

Maria Paola Costi, S. Cole, L. Chiarelli, 2015, ACS chemical biology.

Internalization and stability of a thymidylate synthase Peptide inhibitor in ovarian cancer cells.

Maria Paola Costi, G. Ponterini, G. Cannazza, 2014, Journal of medicinal chemistry.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Maria Paola Costi, Ulrike Wittig, S. Gul, 2019, Journal of medicinal chemistry.

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Maria Paola Costi, G. Ponterini, C. Pozzi, 2018, Vitamins and hormones.

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

Maria Paola Costi, S. Gul, L. Costantino, 2017, European journal of medicinal chemistry.

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Maria Paola Costi, Giuseppe Paglietti, Francisco Gamarro, 2008, Proceedings of the National Academy of Sciences.

Update on antifolate drugs targets.

Maria Paola Costi, M P Costi, S Ferrari, 2001, Current drug targets.

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.

Maria Paola Costi, S. Mangani, L. Cancian, 2011, Journal of medicinal chemistry.

Constrained Dansyl Derivatives Reveal Bacterial Specificity of Highly Conserved Thymidylate Synthases

Maria Paola Costi, S. Ghelli, D. Tondi, 2008, Chembiochem : a European journal of chemical biology.

Sequence‐Based Identification of Specific Drug Target Regions in the Thymidylate Synthase Enzyme Family

Maria Paola Costi, S. Ferrari, Valeria Losasso, 2008, ChemMedChem.

Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase.

Rebecca C Wade, Stefania Ferrari, R. Wade, 2003, Chemistry & biology.

Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma

Maria Paola Costi, V. Conteduca, F. Magni, 2023, Cancers.

High-yield production of major T-cell ESAT6-CFP10 fusion antigen of M. tuberculosis complex employing codon-optimized synthetic gene.

H. Espinosa‐Andrews, F. Milián-Suazo, A. Gutiérrez-Ortega, 2021, International journal of biological macromolecules.

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.

Maria Paola Costi, T. Blundell, G. Ponterini, 2016, Journal of medicinal chemistry.

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.

Maria Paola Costi, S. Ghelli, D. Tondi, 2005, Journal of medicinal chemistry.

Dimer–monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer

M. Caselli, G. Ponterini, G. Guaitoli, 2010, Protein science : a publication of the Protein Society.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Maria Paola Costi, R. Wade, W. Hunter, 2017, ACS omega.

Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Maria Paola Costi, Daniela Cardinale, Giambattista Guaitoli, 2011, Proceedings of the National Academy of Sciences.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

S. Mangani, A. Catalano, C. Pozzi, 2016, European journal of medicinal chemistry.

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.

Maria Paola Costi, R. Stroud, J. Finer-Moore, 2012, Journal of medicinal chemistry.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Biochemical effects of riluzole on Leishmania parasites.

Maria Paola Costi, P. Michels, S. Ferrari, 2013, Experimental parasitology.

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Maria Paola Costi, S. Mangani, L. Costantino, 2013, Journal of medicinal chemistry.

Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase.

Maria Paola Costi, P. Saxena, S. Ferrari, 2013 .

Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Maria Paola Costi, F. Spyrakis, G. Ponterini, 2021, Journal of medicinal chemistry.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

E. Giovannetti, G. Peters, R. Wade, 2022, eLife.

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Molecules.

Anchors away

Maria Paola Costi, S. Ferrari, 2009, Nature.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Maria Paola Costi, R. Stroud, S. Mangani, 2012, Acta crystallographica. Section D, Biological crystallography.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

S. Mangani, M. Costi, P. Linciano, 2023, European journal of medicinal chemistry.

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Maria Paola Costi, W. Hunter, F. Gamarro, 2008, Proceedings of the National Academy of Sciences.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Ulrike Wittig, S. Mangani, V. Hannaert, 2017, ACS omega.

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

A. Cavalli, P. Michels, V. Hannaert, 2012, Journal of medicinal chemistry.

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Kimberley M. Zorn, Daniel H. Foil, S. Ekins, 2023, Journal of medicinal chemistry.

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.

Maria Paola Costi, R. Wade, S. Ferrari, 2013, Bioorganic & medicinal chemistry letters.

Constrained Dansyl Derivatives Reveal Bacterial Specificity of Highly Conserved Thymidylate Synthases

Maria Paola Costi, S. Ghelli, D. Tondi, 2008, Chembiochem : a European journal of chemical biology.

A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors

Maria Paola Costi, S. Ghelli, D. Tondi, 2004 .