H. Zuccola

发表

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.

B. Vought, K. Beaumont, J. Ernst, 2014, Bioorganic & medicinal chemistry letters.

Mycobacterial Nicotinate Mononucleotide Adenylyltransferase

A. Osterman, M. Kazanov, E. Sergienko, 2015, The Journal of Biological Chemistry.

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.

F. Salituro, S. Pazhanisamy, L. Swenson, 2009, Bioorganic & medicinal chemistry letters.

2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis.

Steven J M Jones, Tiansheng Wang, B. VanderVen, 2017, Bioorganic & medicinal chemistry letters.

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.

D. Coen, J. Hogle, K. Ishii, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The crystal structure of monoferric human serum transferrin

H. Zuccola, 1992 .

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.

Kevin J. Gagnon, F. Maltais, P. Charifson, 2021, Journal of medicinal chemistry.

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.

G. Bemis, Tiansheng Wang, B. Hanzelka, 2017, ACS medicinal chemistry letters.

Initiation of Hepatitis Delta Virus Genome Replication

K. Dingle, V. Bichko, Johnm . Taylor, 1998, Journal of Virology.

Interactions between Hepatitis Delta Virus Proteins

K. Dingle, Jinhong Chang, Johnm . Taylor, 2000, Journal of Virology.

Structural basis of the oligomerization of hepatitis delta antigen.

B. W. Erickson, S. Lemon, J. Hogle, 1998, Structure.

The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.

D. Filman, D. Coen, J. Hogle, 2000, Molecular cell.

Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.

Beth A. Fleck, L. Goulet, J. Ernst, 2014, Journal of medicinal chemistry.

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.

F. Salituro, Hui-Sheng Huang, Edmund M. Harrington, 2015, Journal of medicinal chemistry.

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

F. Salituro, Tiansheng Wang, A. Pierce, 2010, Bioorganic & medicinal chemistry letters.

A Novel Chemotype of Kinase Inhibitors

Tiansheng Wang, H. Zuccola, M. Ledeboer, 2009 .

A Point Mutation within Conserved Region VI of Herpes Simplex Virus Type 1 DNA Polymerase Confers Altered Drug Sensitivity and Enhances Replication Fidelity

H. Zuccola, C. B. Hwang, Y. Hwang, 2004, Journal of Virology.

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

S. Snapper, A. Biswas, D. Ostrov, 2019, Nature Medicine.

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

S. Snapper, A. Biswas, Lawrence W. Miller, 2019, Nature Medicine.

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.

Beth A. Fleck, J. Ernst, Michael Liu, 2015, Bioorganic & medicinal chemistry letters.

Three-dimensional structure of poliovirus receptor bound to poliovirus.

B L Trus, A C Steven, D. Filman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Computational design of d-peptide inhibitors of hepatitis delta antigen dimerization

James M. Hogle, Carl D. Elkin, Harmon J. Zuccola, 2000, J. Comput. Aided Mol. Des..