D. Stamos

发表

Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.

B. Vought, K. Beaumont, J. Ernst, 2014, Bioorganic & medicinal chemistry letters.

Multiple binding sites for small molecule antagonists at the chemokine receptor CCR2

A. IJzerman, L. Heitman, M. Doornbos, 2014 .

Multiple Binding Sites for Small-Molecule Antagonists at the CC Chemokine Receptor 2

A. IJzerman, H. de Vries, L. Heitman, 2013, Molecular Pharmacology.

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

A. IJzerman, H. de Vries, L. Heitman, 2017, Scientific Reports.

Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.

R. Heim, J. Abt, A. Termin, 2014, Bioorganic & medicinal chemistry letters.

Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.

P. Charifson, T. Grossman, S. Bellon, 2010, Bioorganic & medicinal chemistry letters.

N-Heterocyclic Carbene Ligand-Enabled C(sp(3))-H Arylation of Piperidine and Tetrahydropyran Derivatives.

jin-quan yu, T. Neubert, D. Stamos, 2016, Chemistry.

Radical mediated C-H functionalization of 3,6-dichloropyridazine: efficient access to novel tetrahydropyridopyridazines.

T. Neubert, D. Stamos, Y. Schmidt, 2015, Organic letters.

Design and synthesis of novel small molecule CCR2 antagonists: evaluation of 4-aminopiperidine derivatives.

A. IJzerman, H. de Vries, L. Heitman, 2014, Bioorganic & medicinal chemistry letters.

DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.

B. Cravatt, T. Wucherpfennig, M. Dix, 2021, Journal of the American Chemical Society.

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Ruben Abagyan, Adriaan P. IJzerman, Irina Kufareva, 2016, Nature.

Evaluation of (4‐Arylpiperidin‐1‐yl)cyclopentanecarboxamides As High‐Affinity and Long‐Residence‐Time Antagonists for the CCR2 Receptor

A. IJzerman, L. Heitman, J. Brussee, 2015, ChemMedChem.

Ni(II)/Cr(II)-Mediated Coupling Reaction: Beneficial Effects of 4-tert-Butylpyridine as an Additive and Development of New and Improved Workup Procedures

Y. Kishi, D. Stamos, Sean S. Chen, 1997 .

Orchestrated triple C-H activation reactions using two directing groups: rapid assembly of complex pyrazoles.

jin-quan yu, D. Stamos, Shengqing Ye, 2015, Angewandte Chemie.

Ligand-Promoted C(sp(3) )-H Olefination en Route to Multi-functionalized Pyrazoles.

jin-quan yu, D. Stamos, Shengqing Ye, 2016, Chemistry.

Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.

P. Charifson, L. Swenson, T. Grossman, 2008, Journal of medicinal chemistry.

When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.

A. IJzerman, H. de Vries, L. Heitman, 2015, European journal of medicinal chemistry.

Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.

John Saunders, Zhiyi Yu, Johannes Brussee, 2013, Journal of medicinal chemistry.

Diastereoselective one-pot Knoevenagel condensation/Corey-Chaykovsky cyclopropanation.

A. Termin, Juliana L. Asgian, J. Ernst, 2013, The Journal of organic chemistry.

Facile preparation of fused ring azolylureas

Tiansheng Wang, S. Tian, D. Deininger, 2007 .

A mild preparation of vinyliodides from vinylsilanes

Y. Kishi, D. Stamos, Andrew G Taylor, 1996 .

New Synthetic Route to the C.14−C.38 Segment of Halichondrins

Y. Kishi, D. Stamos, and Shaowu Chen, 1997 .

Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds

P. Charifson, T. Grossman, E. Olson, 2006, Antimicrobial Agents and Chemotherapy.

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

Wilhelmus E. A. de Witte, A. IJzerman, H. de Vries, 2017, Scientific Reports.

Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy.

P. Charifson, T. Grossman, Tiansheng Wang, 2014, Bioorganic & Medicinal Chemistry Letters.

Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.

Beth A. Fleck, L. Goulet, J. Ernst, 2014, Journal of medicinal chemistry.

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.

Beth A. Fleck, J. Ernst, Michael Liu, 2015, Bioorganic & medicinal chemistry letters.

In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class

P. Charifson, T. Grossman, C. H. Gross, 2006, Antimicrobial Agents and Chemotherapy.

New Synthetic Route to the C.14—C.38 Segment of Halichondrins.

Y. Kishi, Shoujun Chen, D. Stamos, 1998 .

Ligand‐Promoted C(sp3)—H Olefination en Route to Multi‐Functionalized Pyrazoles.

jin-quan yu, D. Stamos, Shengqing Ye, 2016 .