P. Polucci

发表

Cancer Therapy : Preclinical NMS-E 973 , a Novel Synthetic Inhibitor of Hsp 90 with Activity against Multiple Models of Drug Resistance to Targeted Agents , Including Intracranial Metastases

A. Isacchi, E. Casale, E. Felder, 2013 .

NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases

A. Isacchi, E. Casale, E. Felder, 2013, Clinical Cancer Research.

Rational design, synthesis, and biological evaluation of bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) as new anticancer agents.

S. Martelli, I. Antonini, P. Polucci, 2004, Journal of medicinal chemistry.

Catecholic flavonoids acting as telomerase inhibitors.

J. Trosset, R. D'Alessio, D. Ballinari, 2004, Journal of medicinal chemistry.

1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.

L. Kèlland, S. Martelli, B. Stefańska, 1997, Journal of medicinal chemistry.

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.

A. Isacchi, E. Casale, E. Felder, 2014, Bioorganic & medicinal chemistry.

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

S. Neidle, A. Reszka, L. Kelland, 1998, Journal of medicinal chemistry.

Binding free energy of selected anticancer compounds to DNA – theoretical calculations

S. Martelli, M. Bagiński, I. Antonini, 2002, Journal of molecular modeling.

2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: synthesis, biological evaluation, and structure-activity relationships.

L. Kèlland, S. Martelli, I. Antonini, 1999, Journal of medicinal chemistry.

Rational design, synthesis and biological evaluation of thiadiazinoacridines: a new class of antitumor agents.

S. Martelli, I. Antonini, P. Polucci, 2003, Bioorganic & medicinal chemistry.

Synthesis, antitumor cytotoxicity, and DNA-binding of novel N-5,2-di(omega-aminoalkyl)-2,6-dihydropyrazolo[3,4,5-kl]acridine-5-carboxamides.

S. Martelli, I. Antonini, P. Polucci, 2001, Journal of medicinal chemistry.

Benzodipyrazoles: a new class of potent CDK2 inhibitors.

Anna Vulpetti, Alexander Cameron, Roberto D'Alessio, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of (dialkylamino)alkyl-disubstituted pyrimido[5,6,1- de]acridines, a novel group of anticancer agents active on a multidrug resistant cell line.

E. Borowski, S. Martelli, M. Bontemps-Gracz, 1995, Journal of medicinal chemistry.

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

A. Isacchi, E. Casale, T. O'Brien, 2013, Journal of medicinal chemistry.

2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents.

B. Gatto, M. Palumbo, S. Martelli, 2002, Journal of medicinal chemistry.

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents.

B. Gatto, M. Palumbo, S. Martelli, 2003, Journal of medicinal chemistry.

A molecular anchor for stabilizing triple-helical DNA.

S. Neidle, T. C. Jenkins, K. Fox, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Pyrimido [4,5,6-kl] acridines, a new class of potential anticancer agents. Synthesis and biological evaluation.

S. Martelli, M. Bontemps-Gracz, I. Antonini, 1996, Anti-cancer drug design.

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

A. Isacchi, E. Casale, Daniel J. Anderson, 2013, Nature chemical biology.

Synthesis of (Dialkylamino)alkyl‐Disubstituted Pyrimido(5,6,1‐de) acridines (VI), a Novel Group of Anticancer Agents Active on a Multidrug Resistant Cell Line.

E. Borowski, S. Martelli, M. Bontemps-Gracz, 1995 .

N4-(ω-Aminoalkyl)-1-[(ω-aminoalkyl)amino]-4-acridinecarboxamides: Novel, Potent, Cytotoxic, and DNA-Binding Agents

L. Kèlland, S. Martelli, I. Antonini, 2000 .

Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs.

S. Martelli, M. Bontemps-Gracz, G. Palmieri, 1993, Il Farmaco.

Abstract 4785: NMS-E668, a highly potent orally available RET inhibitor with selectivity towards VEGFR2 and demonstrated antitumor efficacy in multiple RET-driven cancer models

A. Isacchi, E. Felder, A. Borgia, 2018, Experimental and Molecular Therapeutics.