Huiping Zhao

发表

Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.

B. Blagg, J. Holzbeierlein, R. Matts, 2013, Assay and drug development technologies.

I. TOTAL SYNTHESIS OF (±) OVALICIN AND ITS ANALOGUES II. BIO-BASED POLYMERS FROM VEGETABLE OIL III. NEW SYNTHETIC METHODS OF DIACETYLENE FATTY ACIDS

Huiping Zhao, 2008 .

Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities.

P. Chiang, Srinivas K. Battina, D. Hua, 2008, Bioorganic & medicinal chemistry.

Novobiocin analogues with second-generation noviose surrogates.

B. Blagg, Huiping Zhao, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.

G. Colombo, E. Moroni, B. Blagg, 2015, European journal of medicinal chemistry.

Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors.

J. Hall, B. Blagg, C. Subramanian, 2014, MedChemComm.

The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα

A. Constantinou, Yiyun Zhang, D. Tonetti, 2007, Nutrition and cancer.

Small Molecule Therapeutics Novel Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant Breast Cancer

G. Thatcher, V. Jordan, P. Maximov, 2014 .

Novel Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant Breast Cancer

G. Thatcher, V. Jordan, P. Maximov, 2014, Molecular Cancer Therapeutics.

Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells

D. Bentrem, A. Constantinou, V. Jordan, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents

B. Blagg, Mark S. Cohen, Stephanie M. Cohen, 2012, Annals of Surgical Oncology.

Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.

Srinivas K. Battina, D. Hua, Kaiyan Lou, 2007, Anticancer research.

Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.

Srinivas K. Battina, D. Hua, Kaiyan Lou, 2007, International journal of oncology.

Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.

Bernard Wiredu, Srinivas K. Battina, D. Hua, 2006, International journal of oncology.

Estradiol-Induced Regression in T47D:A18/PKCα Tumors Requires the Estrogen Receptor and Interaction with the Extracellular Matrix

Yasmin Sitabkhan, Yiyun Zhang, D. Tonetti, 2009, Molecular Cancer Research.

Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model.

Xin Lin, Yiyun Zhang, D. Tonetti, 2005, Carcinogenesis.

Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun

R. Dobrowsky, B. Blagg, Huiping Zhao, 2012, ASN neuro.

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer

Hu Chen, D. Tonetti, Huiping Zhao, 2020 .

Heat Shock Protein 70 Is Necessary to Improve Mitochondrial Bioenergetics and Reverse Diabetic Sensory Neuropathy following KU-32 Therapy

R. Dobrowsky, B. Blagg, Huiping Zhao, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Heat Shock Protein 70 Is Necessary to Improve Mitochondrial Bioenergetics and Reverse Diabetic Sensory Neuropathy following KU-32 Therapy s

R. Dobrowsky, B. Blagg, Huiping Zhao, 2014 .

Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

R. Dobrowsky, B. Blagg, Huiping Zhao, 2012, Experimental Neurology.

Overexpression of leucoanthocyanidin reductase or anthocyanidin reductase elevates tannins content and confers cassava resistance to two-spotted spider mite

Kaimian Li, Songbi Chen, Xiaoqiang Liu, 2022, Frontiers in Plant Science.

Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.

J. Katzenellenbogen, G. Thatcher, D. Tonetti, 2016, Journal of medicinal chemistry.

3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.

B. Blagg, Huiping Zhao, L. Peterson, 2012, ACS medicinal chemistry letters.

Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.

B. Blagg, J. Holzbeierlein, R. Rajewski, 2011, Journal of medicinal chemistry.

Targeting the heat shock protein 90 dimer with dimeric inhibitors.

B. Blagg, J. Holzbeierlein, Huiping Zhao, 2011, Journal of medicinal chemistry.

Cytotoxic sugar analogues of an optimized novobiocin scaffold

Huiping Zhao, Brian S. J. Blagg, B. Blagg, 2010 .

Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors.

B. Blagg, G. Garg, Huiping Zhao, 2017, Chemistry.

Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors.

B. Blagg, G. Garg, Huiping Zhao, 2017, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitors.

B. Blagg, G. Garg, Huiping Zhao, 2015, ACS medicinal chemistry letters.

Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines.

B. Blagg, Mercy Anyika, Huiping Zhao, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.

B. Blagg, Huiping Zhao, B. R. Kusuma, 2010, ACS medicinal chemistry letters.

Synthesis and Evaluation of Noviose Replacements on Novobiocin That Manifest Antiproliferative Activity

B. Blagg, Huiping Zhao, B. R. Kusuma, 2010 .

Novobiocin Analogues That Inhibit the MAPK Pathway.

J. Hall, B. Blagg, G. Garg, 2016, Journal of medicinal chemistry.

C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons.

R. Dobrowsky, B. Blagg, Liangyu Zhang, 2012, Journal of proteome research.

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

Chindo Hicks, Deepali Bhandari, U. Lendahl, 2008, Cancer research.

Hsp90 modulation for the treatment of Alzheimer's disease.

M. Michaelis, B. Blagg, Huiping Zhao, 2012, Advances in pharmacology.

Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion.

Robert J. Gallagher, Peter T. White, B. Blagg, 2016, Surgery.

Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

D. Tonetti, Huiping Zhao, Fariborz Mortazavi, 2017, BMC Cancer.

Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and palbociclib.

G. Thatcher, K. Ratia, D. Tonetti, 2020, Journal of medicinal chemistry.

Identification and initial SAR of silybin: an Hsp90 inhibitor.

B. Blagg, R. Matts, Huiping Zhao, 2011, Bioorganic & medicinal chemistry letters.

Exploiting Conformational Dynamics in Drug Discovery: Design of C-Terminal Inhibitors of Hsp90 with Improved Activities

Giorgio Colombo, Elisabetta Moroni, Huiping Zhao, 2014, J. Chem. Inf. Model..

Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.

G. Thatcher, D. Tonetti, Huiping Zhao, 2017, Journal of medicinal chemistry.

Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer

Yiyun Zhang, D. Tonetti, Huiping Zhao, 2013, Molecular Cancer.

Design and Synthesis of Basic Selective Estrogen Receptor Degraders (B-SERDs) for Endocrine Therapy Resistant Breast Cancer.

Hu Chen, G. Thatcher, D. Tonetti, 2019, Journal of medicinal chemistry.

Retraction Note to: Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer

Yiyun Zhang, D. Tonetti, Huiping Zhao, 2017, Molecular Cancer.

Thiazole antibiotics against breast cancer

A. Gartel, H. Dahari, M. Halasi, 2010, Cell cycle.

Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

D. Tonetti, Huiping Zhao, Fariborz Mortazavi, 2017, BMC Cancer.

The self-association of cytoplasmic malate dehydrogenase 1 promotes malate biosynthesis and confers disease resistance in cassava.

Haitao Shi, Huiping Zhao, Ruoyu Bai, 2023, Plant physiology and biochemistry : PPB.

KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells

B. Blagg, J. Holzbeierlein, Suman Ghosh, 2015, Molecular Pharmacology.

KU 675 , a Concomitant Heat-Shock Protein Inhibitor of Hsp 90 and Hsc 70 that Manifests Isoform Selectivity for Hsp 90 a in Prostate Cancer Cells s

B. Blagg, J. Holzbeierlein, Suman Ghosh, 2015 .

Cross-talk between Notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches (Cancer Research (July 1, 2008) 68 (5226-5235))

U. Lendahl, K. Siziopikou, K. Albain, 2008 .

Syntheses and properties of cross‐linked polymers from functionalized triglycerides

X. Sun, D. Hua, Jian-feng Zhang, 2008 .

Identification of a new scaffold for hsp90 C-terminal inhibition.

G. Colombo, E. Moroni, B. Blagg, 2014, ACS medicinal chemistry letters.

3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.

Elisabetta Moroni, Giorgio Colombo, G. Colombo, 2013, ACS medicinal chemistry letters.