K. Koya

发表

A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors.

R. Bates, Yuan Liu, Dan Zhou, 2013, Toxicology and applied pharmacology.

Preclinical Development Ganetespib , a Unique Triazolone-Containing Hsp 90 Inhibitor , Exhibits Potent Antitumor Activity and a Superior Safety Pro fi le for Cancer Therapy

D. Proia, K. Foley, R. Blackman, 2012 .

Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy

D. Proia, K. Foley, R. Blackman, 2011, Molecular Cancer Therapeutics.

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models

D. Proia, K. Foley, R. Blackman, 2012, Investigational New Drugs.

Antitumor activity of delocalized lipophilic cation, MKT-077 in human carcinomas obtained from fresh surgical specimens

T. Kubota, Y. Otani, Masahiko Watanabe, 1999, International Journal of Clinical Oncology.

Selective antitumor activity of MKT‐077, a delocalized lipophilic cation, on normal cells and cancer cells in vitro

T. Kubota, Y. Otani, M. Kitajima, 1998, Journal of surgical oncology.

Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines.

Lijun Sun, D. A. James, Shoujun Chen, 2006, Bioorganic & medicinal chemistry letters.

Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

Lijun Sun, D. A. James, W. Ying, 2008, Bioorganic & medicinal chemistry letters.

Syntheses and antitumor activities of N'1,N'3-dialkyl-N'1,N'3-di-(alkylcarbonothioyl) malonohydrazide: the discovery of elesclomol.

J. Wu, Lijun Sun, Shoujun Chen, 2013, Bioorganic & medicinal chemistry letters.

Application of DMF–methyl sulfate adduct in the regioselective synthesis of 3-acylated indolizines

Lijun Sun, D. James, Shoujun Chen, 2007 .

Controlling chemoselectivity—application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines

Lijun Sun, Shoujun Chen, K. Koya, 2006 .

Synthesis, crystallographic characterization and electrochemical property of a copper(II) complex of the anticancer agent elesclomol.

Lijun Sun, Shoujun Chen, K. Koya, 2014, Journal of inorganic biochemistry.

Development of a practical synthesis of STA-5312, a novel indolizine oxalylamide microtubule inhibitor

Lijun Sun, Shoujun Chen, K. Koya, 2007 .

Controlling Chemoselectivity—Application of DMF Di‐t‐butyl Acetal in the Regioselective Synthesis of 3‐Monosubstituted Indolizines.

Lijun Sun, Shoujun Chen, K. Koya, 2007 .

Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure–activity relationship

Lijun Sun, D. James, M. Nagai, 2011 .

Application of DMF—Methyl Sulfate Adduct in the Regioselective Synthesis of 3-Acylated Indolizines.

Lijun Sun, D. James, Shoujun Chen, 2007 .

Structure-activity of novel rhodacyanine dyes as antitumor agents.

M. Kawakami, T. Shishido, L. B. Chen, 1998, Journal of medicinal chemistry.

MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.

Shishido, M. Kawakami, L. B. Chen, 1996, Cancer research.

Metacyclophanes and related compounds. 7. Preparation and reduction of [2.2]metacyclophanequinone

K. Koya, T. Yamato, M. Tashiro, 1982 .

Synthesis and Structure of Novel 1,8-Bridged Fluorenophanes†

K. Sakata, A. Tsuge, T. Moriguchi, 1997 .

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells.

R. Blackman, J. Barsoum, J. Chu, 2012, Free radical biology & medicine.

Mortalin inhibition in experimental Parkinson's disease

P. Calabresi, A. Tozzi, L. Binaglia, 2011, Movement disorders : official journal of the Movement Disorder Society.

Mortalin inhibitors sensitize K562 leukemia cells to complement‐dependent cytotoxicity

Z. Fishelson, K. Koya, M. Saar, 2009, International journal of cancer.

MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice.

T. Kubota, Y. Otani, M. Kitajima, 1998, Anticancer research.

Photoactivation enhances the mitochondrial toxicity of the cationic rhodacyanine MKT-077.

J. Modica-Napolitano, L. B. Chen, K. Koya, 1998, Cancer research.

Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.

J. Modica-Napolitano, E. Weisberg, L. B. Chen, 1996, Cancer research.

Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling

D. Proia, K. Foley, R. Bates, 2011, PloS one.

Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent

M. Kawakami, N. Suzuki, T. Shishido, 1999, Cancer Chemotherapy and Pharmacology.

Artificial DnaJ Protein for protein production and conformational diseases

A. Hishiya, K. Koya, 2017, Scientific Reports.

AN IMPROVED SYNTHESIS OF 1,3-BIS(5-t-BUTYL-2-SUBSTITUTED PHENYL)PROPANES

H. Sakamoto, A. Tsuge, K. Koya, 1987 .

Abstract C212: A critical role for the tissue distribution profile in heat shock protein (Hsp) 90 inhibitor-induced ocular toxicity in rats.

Yuan Liu, Dan Zhou, J. Ye, 2011 .

In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function.

J. Modica-Napolitano, E. Weisberg, L. B. Chen, 1996, Cancer research.

Synthesis and evaluation of novel rhodacyanine dyes that exhibit antitumor activity.

M. Kawakami, T. Shishido, L B Chen, 1997, Journal of medicinal chemistry.

Artificial DnaJ Protein for protein production and conformational diseases

A. Hishiya, K. Koya, 2017, Scientific Reports.

Syntheses and antitumor activities of N'1,N'3-dialkyl-N'1,N'3-di-(alkylcarbonothioyl) malonohydrazide: the discovery of elesclomol.

Lijun Sun, Jim Z Wu, Shoujun Chen, 2013, Bioorganic & Medicinal Chemistry Letters.

STA-4783, a novel HSP inducer, enhances paclitaxel activity-Preclinical to clinical modeling.

R. Salgia, A. Berkenblit, T. Dahl, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.