J. Peyrat

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Inhibitors of the heat shock protein 90: from cancer clinical trials to neurodegenerative diseases

J. Peyrat, S. Messaoudi, J. Brion, 2011 .

Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010

J. Peyrat, S. Messaoudi, J. Brion, 2011, Expert opinion on therapeutic patents.

Cs2CO3 in pyrrolidinone promoted hydration of functionalized (hetero)aryl nitriles under metal-free conditions

J. Peyrat, S. Messaoudi, J. Brion, 2012 .

A general copper powder-catalyzed Ullmann-type reaction of 3-halo-4(1H)-quinolones with various nitrogen-containing nucleophiles.

J. Peyrat, S. Messaoudi, J. Brion, 2011, The Journal of organic chemistry.

p-Toluenesulfonic acid-mediated cyclization of o-(1-alkynyl)anisoles or thioanisoles: synthesis of 2-arylsubstituted benzofurans and benzothiophenes

J. Peyrat, J. Brion, M. Alami, 2009 .

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.

Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3.

J. Peyrat, J. Brion, Emmanuel Thomas, 2014, European journal of medicinal chemistry.

Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.

T. Szekeres, W. Jäger, S. Krieger, 2012, Human molecular genetics.

Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.

J. Renoir, C. Radanyi, M. Catelli, 2009, Cancer letters.

Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.

J. Renoir, C. Radanyi, J. Peyrat, 2009, Biochemical and biophysical research communications.

Discovery and Biological Activity of 6BrCaQ as an Inhibitor of the Hsp90 Protein Folding Machinery

J. Renoir, C. Radanyi, J. Peyrat, 2011, ChemMedChem.

Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

J. Renoir, C. Radanyi, V. Marsaud, 2008, Bioorganic & medicinal chemistry letters.

13C‐Labelled (±±)‐Catechin From Potassium [13C]Cyanide

J. Mérillon, B. Nay, J. Vercauteren, 2000 .

A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles.

J. Peyrat, S. Messaoudi, J. Brion, 2013, Organic & biomolecular chemistry.

Palladium-Catalyzed Cross-Coupling of 1-Aminoazoles with Aryl Chlorides: Application to the Synthesis of Unsymmetrical N,N′-Diaryl-1-aminoindoles

J. Peyrat, S. Messaoudi, J. Brion, 2012 .

Crystal structure of 3-[(2,2-dimethylchroman-6-yl)carbonylamino]-7-hydroxy- 8-methyl-2-oxo-2H-chromen-4-yl toluene-4-sulfonate, C29H27NO8S

J. Peyrat, J. Brion, M. Alami, 2008 .

Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

R. Hocquemiller, B. Figadère, X. Franck, 2004 .

Versatile palladium(II)-catalyzed Negishi coupling reactions with functionalized conjugated alkenyl chlorides

J. Peyrat, J. Brion, M. Alami, 2003 .

A convenient and expeditious synthesis of 3-(N-substituted) aminocoumarins via palladium-catalyzed Buchwald–Hartwig coupling reaction

J. Peyrat, S. Messaoudi, J. Brion, 2007 .

Synthesis and characterization of low generation halogenated linear poly(arylpropargyl)ether (PAPE) branches via selective palladium catalyzed coupling reactions

J. Peyrat, J. Brion, M. Alami, 2005 .

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

J. Peyrat, J. Brion, M. Alami, 2013, Anti-cancer agents in medicinal chemistry.

Assessing the chemical diversity of an hsp90 database.

F. Petitet, E. Dubus, I. Ijjaali, 2010, European journal of medicinal chemistry.

α-iodination of ketones with MnO2/I2 reagent combination : A new environmentally friendly procedure

J. Peyrat, J. Brion, M. Alami, 2006 .

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2013, Organic & biomolecular chemistry.

Three-component one-pot process to propargylic amines and related amide and sulfonamide compounds: application to the construction of 2-(aminomethyl)benzofurans and indoles

S. Sicsic, I. Berque-Bestel, J. Peyrat, 2007 .

Tandem amine propargylation-Sonogashira reactions: new three-component coupling leading to functionalized substituted propargylic amines

J. Peyrat, J. Brion, M. Alami, 2004 .

p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles

J. Peyrat, J. Brion, M. Alami, 2010 .

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives.

S. Cojean, C. Bories, P. Loiseau, 2012, European journal of medicinal chemistry.

Rapid microwave assisted hydration of internal arylalkynes in the presence of PTSA : an efficient regioselective access to carbonyl compounds

J. Peyrat, J. Brion, M. Alami, 2006 .

Highly efficient p-toluenesulfonic acid-catalyzed alcohol addition or hydration of unsymmetrical arylalkynes

J. Peyrat, J. Brion, M. Alami, 2004 .

New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

B. Stella, J. Renoir, C. Radanyi, 2007, Journal of medicinal chemistry.

Three‐Component One‐Pot Process to Propargylic Amines and Related Amide and Sulfonamide Compounds: Application to the Construction of 2‐(Aminomethyl)benzofurans and Indoles.

S. Sicsic, I. Berque-Bestel, J. Peyrat, 2008 .

Stereoselective synthesis of (E)-chloroenynes or (E,E)-chlorodienes starting from a stereoisomeric mixture of 1,2-dichloroethylenes

J. Peyrat, J. Brion, M. Alami, 2002 .

1,2-Dihalogenalkenes: Useful Linchpins to Unsaturated Compounds via Palladium or Nickel Catalysis

J. Peyrat, J. Brion, M. Alami, 2000 .

Tandem Amine Propargylation-Sonogashira Reactions: New Three-Component Coupling Leading to Functionalized Substituted Propargylic Amines.

J. Peyrat, J. Brion, M. Alami, 2004 .

Ortho substituents direct regioselective addition of tributyltin hydride to unsymmetrical diaryl (or heteroaryl) alkynes: an efficient route to stannylated stilbene derivatives.

J. Peyrat, J. Brion, M. Alami, 2002, Angewandte Chemie.

Synthetic 2-methoxyestradiol derivatives: structure-activity relationships.

J. Peyrat, J. Brion, M. Alami, 2012, Current medicinal chemistry.

Phenols as C‐ and O‐Nucleophiles in Palladium‐Catalysed Allylic Substitutions

B. Nay, J. Vercauteren, J. Peyrat, 1999 .

Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4.

J. Peyrat, J. Brion, M. Alami, 2010, Organic letters.

Microwave-assisted Pd(OH)2-catalyzed direct C−H arylation of free-(NH2) adenines with aryl halides

J. Peyrat, S. Messaoudi, J. Brion, 2008 .

Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation

A. Giraud, J. Peyrat, J. Brion, 2006 .

Efficient Syntheses of New Heteroarotinoids through Functional Pyridylzinc Reagents and Palladium‐Catalyzed Cross‐Coupling Reactions

J. Peyrat, J. Brion, M. Alami, 2001 .

Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3

A. Giraud, J. Peyrat, J. Brion, 2006 .

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.

J. Bignon, J. Dubois, J. Peyrat, 2013, Organic & biomolecular chemistry.

A formal stereoselective synthesis of a hydroxyethylene dipeptide isostere

B. Figadère, J. Peyrat, A. Cavé, 1995 .

Acetogenins of annonaceae. Part 86: synthesis of a highly functionalized precursor of (−)-4-deoxygigantecin, an annonaceous acetogenin

R. Hocquemiller, B. Figadère, X. Franck, 2000 .

Replicative Chirons: Stereoselective Synthesis of Oligo-Tetrahydrofuranic Lactones via C-Glycosylation with [(Trimethylsilyl)oxy]furan

B. Figadère, J. Peyrat, A. Cavé, 1997 .

Study of the binding affinity of oligo-tetrahydrofuranic γ-lactones with cations

B. Figadère, J. Peyrat, A. Cavé, 1995 .

Stereocontrolled synthesis of key intermediates in the total synthesis of acetogenins of annonaceae

B. Figadère, J. Peyrat, A. Cavé, 1993 .

Highly substituted enynes via a palladium-catalyzed tandem three carbon-carbon bonds forming reaction procedure from benzyl halides and alkynyl tributyltin reagents

L. Pottier, J. Peyrat, J. Brion, 2004 .

Carbonyl Reduction of Functionalized Aldehydes and Ketones by Tri-n-Butyltin Hydride and SiO2

B. Figadère, X. Franck, J. Peyrat, 1994 .

NMR STUDIES OF CA2+ COMPLEXES OF ANNONACEOUS ACETOGENINS

B. Figadère, J. Peyrat, A. Cavé, 1997 .

Study of the structure-activity relationships of the acetogenin of annonaceae, muricatacin and analogues

A. Laurens, J. Harmange, B. Figadère, 1997 .

Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2009, Journal of medicinal chemistry.

p-Toluenesulfonic Acid-Promoted Selective Functionalization of Unsymmetrical Arylalkynes: A Regioselective Access to Various Arylketones and Heterocycles.

J. Peyrat, J. Brion, M. Alami, 2010 .

Synthetic approach to enyne and enediyne analogues of anticancer agents

A. Giraud, J. Peyrat, J. Brion, 2005 .

Palladium-catalyzed stereoselective synthesis of E- and Z-1,1-diaryl or triarylolefins

J. Peyrat, J. Brion, M. Alami, 2003 .

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.

P. Colas, P. Bonnet, J. Bignon, 2020, European journal of medicinal chemistry.

Palladium‐Catalyzed Stereoselective Synthesis of E‐ and Z‐1,1‐Diaryl or Triarylolefins.

J. Peyrat, J. Brion, M. Alami, 2003 .

An Efficient Coupling of N‐Tosylhydrazones with 2‐Halopyridines: Synthesis of 2‐α‐Styrylpyridines Endowed with Antitumor Activity.

J. Bignon, J. Dubois, J. Peyrat, 2013 .

Recent advances in Hsp90 inhibitors as antitumor agents.

J. Peyrat, S. Messaoudi, J. Brion, 2008, Anti-cancer agents in medicinal chemistry.

Synthesis of Poly(aryl propargyl ether) (PAPE) Stars and Evaluation of Their Cytotoxic Properties

P. Hildgen, J. Peyrat, J. Brion, 2008 .

Iron-Catalyzed Coupling Reaction Between 1,1-Dichloro-1-alkenes and Grignard Reagents.

R. Hocquemiller, B. Figadère, X. Franck, 2005 .

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.