J. Ali

发表

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

James R. Porter, J. Sydor, J. Adams, 2006, Journal of medicinal chemistry.

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

V. Palombella, Johan A. Pradeilles, Ann M. Rowley, 2016, ACS medicinal chemistry letters.

An oligomeric form of E. coli UvrD is required for optimal helicase activity.

T. Lohman, N. K. Maluf, J. Ali, 1999, Journal of molecular biology.

Kinetic Mechanism for Formation of the Active, Dimeric UvrD Helicase-DNA Complex*

T. Lohman, N. K. Maluf, J. Ali, 2003, Journal of Biological Chemistry.

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo

K. West, J. Adams, V. Palombella, 2010, The Journal of Biological Chemistry.

Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.

G. Orphanides, A. Maxwell, J. Ali, 1995, Biochemistry.

Anti-Tumor Activity of IPI-504, a Novel Hsp90 Inhibitor in Multiple Myeloma.

J. Sydor, M. Foley, C. Mitsiades, 2004 .

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

A. Maxwell, A Maxwell, A J Howells, 1993, Biochemistry.

Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.

S. Peluso, K. West, V. Palombella, 2012, Journal of medicinal chemistry.

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

Jie Ge, James R. Porter, J. Sydor, 2006, Proceedings of the National Academy of Sciences.

DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies.

T. Lohman, A. Vindigni, R. Gregorian, 2002, Journal of molecular biology.

Kinetic Measurement of the Step Size of DNA Unwinding by Escherichia coli UvrD Helicase

T. Lohman, J. Ali, 1997, Science.

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.

Bonnie Tillotson, James R. Porter, Pingda Ren, 2013, Chemistry & biology.

HSP90 Inhibition Enhances Antimitotic Drug-Induced Mitotic Arrest and Cell Death in Preclinical Models of Non-Small Cell Lung Cancer

J. Kutok, H. Stern, K. West, 2014, PloS one.

Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.

S. Neuteboom, M. Groll, T. Chao, 2008, Journal of medicinal chemistry.