T. Tibbitts

发表

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

James R. Porter, J. Sydor, J. Adams, 2006, Journal of medicinal chemistry.

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.

V. Palombella, Johan A. Pradeilles, Ann M. Rowley, 2016, ACS medicinal chemistry letters.

Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.

E. Kantrowitz, J. Murphy, T. Tibbitts, 1996, Journal of molecular biology.

Escherichia coli alkaline phosphatase: X‐ray structural studies of a mutant enzyme (His‐412 → Asn) at one of the catalytically important zinc binding sites

E. Kantrowitz, T. Tibbitts, L. Ma, 1995, Protein science : a publication of the Protein Society.

Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity

J. Kutok, M. Read, J. Proctor, 2014, PloS one.

Diffraction diagnosis of protein folding in gap junction connexons.

D. Caspar, D. Goodenough, T. Tibbitts, 1990, Biophysical journal.

Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.

Maolin Yu, John F. Reilly, M. Beconi, 2019, ACS medicinal chemistry letters.

Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.

E. Kantrowitz, J. Murphy, T. Tibbitts, 1995, Journal of molecular biology.

of the catalytically important zinc binding sites

E. Kantrowitz, T. Tibbitts, Lan Ma, 1995 .

Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp‐369 → Asn): A mechanism involving one zinc per active site

E. Kantrowitz, T. Tibbitts, Xu Xu, 1994, Protein science : a publication of the Protein Society.

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

J. Kutok, J. Wolchok, Sujata Sharma, 2016, Nature.

Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119.

Lawrence W. C. Chan, M. Loda, S. Peluso, 2013 .

Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199)

M. Ayers, J. Kutok, H. Stern, 2017, Leukemia.

A translational kidney organoid system bolsters human relevance of clinical development candidate

M. Emani, J. Harmange, P. Mundel, 2019, bioRxiv.

Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

M. Emani, J. Harmange, P. Mundel, 2022, Science advances.