Heather L. Osswald

发表

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Arun K. Ghosh, Arun K Ghosh, Heather L. Osswald, 2016, Journal of medicinal chemistry.

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

Arun K. Ghosh, A. Mesecar, S. Baker, 2014, Journal of Virology.

Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, Journal of medicinal chemistry.

Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization.

Arun K. Ghosh, Heather L. Osswald, Chun-xiao Xu, 2015, Tetrahedron letters.

Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

Arun K. Ghosh, D. Walters, H. Mitsuya, 2014, Organic & biomolecular chemistry.

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2013, Journal of medicinal chemistry.

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Arun K. Ghosh, Heather L. Osswald, 2014, Chemical Society reviews.

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, ChemMedChem.

The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease

Arun K. Ghosh, E. L. Cárdenas, Heather L. Osswald, 2016 .

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, Nature communications.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, bioRxiv.

Modular, stereocontrolled Cβ–H/Cα–C activation of alkyl carboxylic acids

Julien C. Vantourout, S. Schreiber, B. Melillo, 2019, Proceedings of the National Academy of Sciences.

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, European journal of medicinal chemistry.

HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand

I. Weber, J. Agniswamy, S. Hattori, 2018 .

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2016, Journal of medicinal chemistry.

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Journal of medicinal chemistry.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Journal of medicinal chemistry.

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.

Irene T Weber, Yuan-Fang Wang, Debananda Das, 2017, Journal of medicinal chemistry.

Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2020, Journal of medicinal chemistry.

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Arun K. Ghosh, A. Mesecar, Sarah E. St. John, 2015, The Journal of Biological Chemistry.

A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Lisa E. Gralinski, Vineet D. Menachery, Arun K. Ghosh, 2014, mBio.

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Arun K. Ghosh, A. Mesecar, Sarah E. St. John, 2015, Bioorganic & Medicinal Chemistry Letters.

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer.

Patrick W. Fedick, R. M. Bain, R. Cooks, 2017, Analytical chemistry.

Generative Molecular Design and Experimental Validation of Selective Histamine H1 Inhibitors

Jonathan E. Allen, R. Abagyan, M. Head, 2023, bioRxiv.