C. Nouhan

5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.

G. Zeikus, E. Lunney, S. Gulnik, 2000, Journal of medicinal chemistry.

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.

G. Zeikus, C. Humblet, E. Lunney, 1999, Bioorganic & medicinal chemistry.

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.

E. Lunney, S. Hagen, J. Domagala, 1997, Journal of medicinal chemistry.

Nonpeptidic HIV protease inhibitors: 3-(S-benzyl substituted)-4-hydroxy-6-(phenyl substituted)-2H-pyran-2-one with an inverse mode of binding

D. Ferguson, E. Ellsworth, A. Pavlovsky, 1996 .

4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.

G. Zeikus, E. Lunney, S. Hagen, 1999, Bioorganic & medicinal chemistry letters.

Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.

E. Lunney, S. Hagen, J. Domagala, 1999, Bioorganic & medicinal chemistry letters.

Discovery and optimization of nonpeptide HIV-1 protease inhibitors.

E. Lunney, S. Hagen, J. Domagala, 1996, Bioorganic & medicinal chemistry.

4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.

C. Humblet, E. Lunney, S. Gulnik, 1997, Journal of medicinal chemistry.