H. Sore

发表

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery

D. Spring, T. A. King, H. Stewart, 2019, European journal of organic chemistry.

Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

J. Brenton, D. Spring, L. Itzhaki, 2016, Angewandte Chemie.

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

Matthew N. Grayson, D. Spring, L. Itzhaki, 2020, ACS omega.

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

Andreas Bender, David R Spring, Leen Kalash, 2018, Chemistry.

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

Preparation of kinase‐biased compounds in the search for lead inhibitors of kinase targets

A. Henry, S. Langston, N. Grimster, 2005, Medicinal research reviews.

Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA)

D. Spring, M. Welch, N. Robertson, 2020, ChemMedChem.

Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology

D. Spring, Feilin Nie, S. Bartlett, 2016, Synthesis.

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Organic & biomolecular chemistry.

Efficient and selective antibody modification with functionalised divinyltriazines.

Stephen J. Walsh, D. Spring, N. Robertson, 2020, Organic & biomolecular chemistry.

Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

D. Spring, H. Sore, Andrea Renzetti, 2019, Synlett.

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file.

D. Spring, D. Russell, H. Sore, 2017, Organic and biomolecular chemistry.

Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone.

D. Spring, D. Russell, H. Sore, 2017, Journal of natural products.

Palladium-catalysed cross-coupling of organosilicon reagents.

D. Spring, W. R. Galloway, H. Sore, 2012, Chemical Society reviews.

Vinyldisiloxanes: their synthesis, cross coupling and applications.

D. Spring, Luca Laraia, W. R. Galloway, 2011, Organic & biomolecular chemistry.

Fluoride-free cross coupling using vinyldisiloxanes.

D. Spring, S. Macdonald, D. Fox, 2009, Organic & biomolecular chemistry.

Second-generation CK2α inhibitors targeting the αD pocket† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See DOI: 10.1039/c7sc05122k

D. Spring, P. Brear, M. Rossmann, 2018, Chemical science.

Synthesis and SAR of novel GPR39 Agonists and Positive Allosteric Modulators

Lewis H. Mervin, Justin J. W. Powell, R. Bürli, 2022, Bioorganic & Medicinal Chemistry Letters.

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

D. Spring, L. Itzhaki, M. Hyvönen, 2019, Organic & biomolecular chemistry.

Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials.

Kieron M. G. O'Connell, D. Spring, M. Welch, 2013, Angewandte Chemie.

An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics

Warren R. J. D. Galloway, David R. Spring, Cornelius J. O'Connor, 2016 .

Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection

Warren R. J. D. Galloway, David R. Spring, D. Spring, 2016, Angewandte Chemie.

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional

Stephen J. Walsh, David R Spring, Martin Welch, 2017, Chemical science.

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

David R. Spring, Martin Welch, Kieron M. G. O'Connell, 2013 .

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

D. Spring, J J Ciardiello, H L Stewart, 2017, Bioorganic & medicinal chemistry.

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

D. Spring, Y. S. Tan, W. R. Galloway, 2015, Organic & biomolecular chemistry.

High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays

D. Spring, H. Sore, David Norton, 2010 .

(Z)-Selective Takai olefination of salicylaldehydes

D. Spring, J. Goodman, W. R. Galloway, 2017, Beilstein journal of organic chemistry.

Strategies for the Diversity-Oriented Synthesis of Macrocycles.

D. Spring, T. A. King, Kim T Mortensen, 2019, Chemical reviews.

Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides.

Kieron M. G. O'Connell, D. Spring, D. G. Hulcoop, 2011, Chemistry.

Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future

D. Spring, M. Hyvönen, N. Robertson, 2018, Advanced Therapeutics.

Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol.

D. Spring, D. Russell, A. Bond, 2018, Organic & biomolecular chemistry.

Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.

D. Spring, S. L. Kidd, A. North, 2019, Organic letters.

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, N. Robertson, 2019, Chemical communications.

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, Chemical communications.

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

Stephen J. Walsh, D. Spring, L. Itzhaki, 2019, ACS chemical biology.

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

D. Spring, M. Hyvönen, A. North, 2018, Bioorganic & medicinal chemistry.

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.

D. A. Russell, D. Spring, D. Russell, 2020, Journal of natural products.

A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

Warren R. J. D. Galloway, David R. Spring, Hannah F. Sore, 2016, Angewandte Chemie.

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.

D. Spring, M. Welch, G. Salmond, 2010, Organic & biomolecular chemistry.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

David R. Spring, Marko Hyvönen, D. Spring, 2017, Bioorganic & medicinal chemistry.

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion†

Anthony R. Bradley, Christopher G. Dowson, Katherine E. McAuley, 2020, Chemical science.

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds.

D. Spring, A. Bond, T. Moss, 2020, Chemical communications.

Second-generation CK2 alpha inhibitors targeting the alpha D pocket.

D. Spring, M. Rossmann, M. Hyvönen, 2018 .

Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface.

D. Spring, M. Hyvönen, A. North, 2018 .

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

David R. Spring, Sarah L. Kidd, Natalia Mateu, 2018, Front. Chem..

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

D. Spring, Y. S. Tan, C. Verma, 2018, Chemical science.

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

David R. Spring, D. Spring, M. Rossmann, 2016, Chembiochem : a European journal of chemical biology.

D. Spring, Y. S. Tan, C. Verma, 2019, Chemical science.

CHAPTER 8:Double-click Stapled Peptides for Inhibiting Protein–Protein Interactions

D. Spring, L. Itzhaki, Y. H. Lau, 2017 .

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

D. Spring, H. Sore, J. Ciardiello, 2017, Bioorganic & medicinal chemistry.

Stephen J. Walsh, D. Spring, M. Welch, 2017, Chemical science.

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, Yuteng Wu, 2019, Chemical communications.

Second-generation CK2α inhibitors targeting the αD pocket

D. Spring, P. Brear, M. Rossmann, 2018, Chemical science.