H. Twin

发表

Substituted 2,5-diazabicyclo[4.1.0]heptanes and their application as general piperazine surrogates: synthesis and biological activity of a Ciprofloxacin analogue

R. Batey, S. Gray-Owen, A. Lough, 2010 .

Intramolecular hetero Diels-Alder (Povarov) approach to the synthesis of the alkaloids luotonin A and camptothecin.

R. Batey, H. Twin, 2004, Organic letters.

A biogenetically inspired heterodimerization approach to the synthesis of the core structure of the alkaloid fissoldhimine

R. Batey, A. Lough, D. Powell, 2007 .

Intramolecular Hetero Diels—Alder (Povarov) Approach to the Synthesis of the Alkaloids Luotonin A and Camptothecin.

R. Batey, H. Twin, 2005 .

Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.

R. Heim, J. Abt, A. Termin, 2014, Bioorganic & medicinal chemistry letters.

Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis.

L. Settimo, A. Tanner, H. Twin, 2019, ACS medicinal chemistry letters.

A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles.

T. Donohoe, H. Twin, Roly J. Armstrong, 2020, Chemical communications.

Asymmetric synthesis of 2-substituted piperidines using a multi-component coupling reaction: rapid assembly of (S)-coniine from (S)-1-(1-phenylethyl)-2-methyleneaziridine.

M. Shipman, J. Hayes, H. Twin, 2001, Chemical communications.

A Lewis acid catalyzed intramolecular [4+3] cycloaddition route to polycyclic systems that contain a seven-membered ring.

M. Shipman, J. Hayes, H. Twin, 2004, Angewandte Chemie.

Multicomponent reactions involving 2-methyleneaziridines: rapid synthesis of 1,3-disubstituted propanones.

M. Shipman, J. Hayes, H. Twin, 2002, The Journal of organic chemistry.

Aziridinyl anions from a chiral, nonracemic 2-isopropylidineaziridine: surprisingly diastereoselective alkylation reactions.

A. Slawin, M. Shipman, I. Prokes, 2003, Chemical communications.

Generation of metalloenamines by carbon–carbon bond formation: ring opening reactions of 2-methyleneaziridines with organometallic reagents

M. Shipman, J. Hayes, H. Twin, 2000 .

Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.

P. Reaper, J. Golec, M. Griffiths, 2019, Journal of medicinal chemistry.

Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.

A. Tanner, H. Twin, J. Jiménez, 2011, Journal of medicinal chemistry.

Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases.

L. Settimo, A. Tanner, Jaclyn L Henderson, 2013, Journal of medicinal chemistry.