Jean Martinez

发表

Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors.

F. Hoh, A. Padilla, Y. Boublik, 2013, Journal of medicinal chemistry.

Identification of Key Residues for Interaction of Vasoactive Intestinal Peptide with Human VPAC1 and VPAC2Receptors and Development of a Highly Selective VPAC1Receptor Agonist

Annick Thomas, R. Brasseur, L. Lins, 2000, The Journal of Biological Chemistry.

Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases

J. Buxbaum, O. Khorkova, S. Sahasrabudhe, 1997, Molecular medicine.

1,2,4‐Triazole‐3‐thione Compounds as Inhibitors of Dizinc Metallo‐β‐lactamases

J. Frère, C. Condon, K. Becker, 2017, ChemMedChem.

Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein.

F. Checler, J. Sévalle, Jean‐François Hernandez, 2013, Bioorganic & medicinal chemistry.

Design and characterization of a new cell-permeant inhibitor of the b -secretase BACE1

F. Checler, Jean‐François Hernandez, V. Lisowski, 2005 .

Cathepsin D displays in vitro β-secretase-like specificity

M. Goedert, M. Spillantini, F. Checler, 1997, Brain Research.

Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors

J. Boucher, Jean‐François Hernandez, Jean Martinez, 2020, ChemMedChem.

Coarse-grained simulations of the HIV-1 matrix protein anchoring: revisiting its assembly on membrane domains.

L. Chaloin, D. Muriaux, C. Favard, 2014, Biophysical journal.

Cyclic peptides with a diversely substituted guanidine bridge: solid-phase synthesis and structural analysis.

L. Chiche, Jean‐François Hernandez, V. Lisowski, 2011, Chemistry.

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of α-secretase

F. Checler, M. Cissé, B. Vincent, 2006 .

Novel Cathepsin D Inhibitors Prevent the β-Secretase-Derived Intracellular Formation of a 12 kDa Potentially Amyloidogenic Product in Human Cells

M. Goedert, M. Spillantini, F. Checler, 1997 .

Solid phase synthesis of mono- or disubstituted arginine containing peptides from an isothiocitrulline precursor

Jean‐François Hernandez, V. Lisowski, Céline Gandreuil, 2005 .

Structure–activity relationships of novel peptide agonists of the human bradykinin B2 receptor

M. Amblard, W. Neugebauer, Jean Martinez, 2009, Peptides.

Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.

Jean‐François Hernandez, T. Verbeuren, Jean Martinez, 2009, Bioorganic & medicinal chemistry letters.

Cytotoxic activity of new racemic and optically active N-phosphonoalkyl bicyclic β-amino acids against human malignant cell lines

D. Wesselinova, M. Calmès, Jean Martinez, 2012, Amino Acids.

Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β3- and α-Amino Acids from Fmoc-Protected Aspartic Acid

Jean‐François Hernandez, Jean Martinez, P. Fulcrand, 2003 .

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.

S. Bertout, Fatih Demirci, Jean Martinez, 2013, Bioorganic & medicinal chemistry letters.

Design and characterization of a new cell‐permeant inhibitor of the β‐secretase BACE1

Vincent Lisowski, Jean-François Hernandez, F. Checler, 2005, British journal of pharmacology.

Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.

Jean‐François Hernandez, P. Schiller, N. N. Chung, 2013, Journal of medicinal chemistry.

Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes.

P. Bisch, D. Pérahia, P. R. Batista, 2015, Biophysical journal.

BACE1- and BACE2-expressing Human Cells

F. Checler, Jean‐François Hernandez, M. Farzan, 2003, Journal of Biological Chemistry.

Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

G. Rougon, M. Khrestchatisky, P. Vlieghe, 2012, Journal of medicinal chemistry.

Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9.

M. Amblard, J. Le Bail, B. Legrand, 2021, Journal of medicinal chemistry.

Synthesis and characterization of a cyclooctapeptide analogue of ω-agatoxin IVB enhancing the activity of CaV2.1 calcium channels activity in cultured hippocampal neurons

J. Guiramand, M. Vignes, M. Cavalier, 2012, Neurochemistry International.

Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors

Nicolas Floquet, Landry Charlier, Jean Martinez, 2017, J. Chem. Inf. Model..

Pharmacological evidences for DFK167‐sensitive presenilin‐independent γ‐secretase‐like activity

F. Checler, J. Sévalle, Jean‐François Hernandez, 2009, Journal of neurochemistry.

l-Arginine Binding to Human Inducible Nitric Oxide Synthase: An Antisymmetric Funnel Route toward Isoform-Specific Inhibitors?

Nicolas Floquet, Jean-François Hernandez, Jean-Luc Boucher, 2011, J. Chem. Inf. Model..

BACE1- and BACE2-expressing Human Cells CHARACTERIZATION OF (cid:1) -AMYLOID PRECURSOR PROTEIN-DERIVED CATABOLITES, DESIGN OF A NOVEL FLUORIMETRIC ASSAY, AND IDENTIFICATION OF NEW IN VITRO INHIBITORS*

F. Checler, Jean‐François Hernandez, M. Farzan, 2003 .

Synthesis and activity of HIV protease inhibitors

P. Dumy, S. Sicsic, M. Reboud-Ravaux, 1998 .

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.

F. Checler, Jean‐François Hernandez, V. Lisowski, 2005, British journal of pharmacology.

A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins.

D. Pérahia, M. Louet, N. Floquet, 2011, Journal of Molecular Biology.

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase.

F. Checler, B. Vincent, Jean‐François Hernandez, 2006, Biochemical and biophysical research communications.

Kinetics, inhibition and oligomerization of Epstein‐Barr virus protease

M. Buisson, M. Jamin, Jean‐François Hernandez, 2006, FEBS letters.

Dissociation of Membrane-Anchored Heterotrimeric G-Protein Induced by Gα Subunit Binding to GTP

Maxime Louet, Jean Martinez, Nicolas Floquet, 2012, J. Chem. Inf. Model..

GDP Release Preferentially Occurs on the Phosphate Side in Heterotrimeric G-proteins

Maxime Louet, Jean Martinez, Nicolas Floquet, 2012, PLoS Comput. Biol..

Solid-phase synthesis of arginine-containing peptides and fluorogenic substrates using a side-chain anchoring approach.

Jean‐François Hernandez, Jean Martinez, Abdallah Hamze, 2004, The Journal of organic chemistry.

Solid-phase synthesis of dipeptidic and pseudo-dipeptidic potential NOS inhibitors through a side-chain anchoring approach.

Jean‐François Hernandez, Jean Martinez, P. Fulcrand, 2009, Advances in Experimental Medicine and Biology.

Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

G. Rougon, M. Khrestchatisky, P. Vlieghe, 2012, Journal of medicinal chemistry.

Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors

P. Renault, N. Floquet, Jean Martinez, 2017, J. Chem. Inf. Model..