D. Roche

发表

Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.

E. Valeur, F. Schmidlin, Franck F. Lepifre, 2009, Bioorganic & medicinal chemistry letters.

Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation.

J. Cherfils, A. Morel, A. Blangy, 2020, Journal of medicinal chemistry.

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Xuliang Jiang, Didier Roche, Daniel Schwarz, 2019, Bioorganic & Medicinal Chemistry Letters.

Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.

R. Morgentin, M. Clausen, T. Nielsen, 2016, Organic & biomolecular chemistry.

Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.

Adam Nelson, Mark Dow, Tuomo Kalliokoski, 2015, Bioorganic & medicinal chemistry.

Enantioselective acylation of β-aminoesters using penicillin G Acylase in organic solvents

D. Roche, K. Prasad, O. Repič, 1999 .

The metabolic sensors FXR (cid:1) , PGC-1 (cid:1) , and SIRT1 cooperatively regulate hepatitis B virus transcription

P. André, V. Lotteau, C. Scholtès, 2014 .

Therapeutic potential of compounds targeting SARS-CoV-2 helicase

S. Abeln, G. Wuite, M. Wever, 2022, Frontiers in Chemistry.

Efficient, mild, parallel and purification-free synthesis of aryl ethers via the Mitsunobu reaction

E. Valeur, D. Roche, 2008 .

Efficient, Mild, Parallel and Purification-Free Synthesis of Aryl Ethers via the Mitsunobu Reaction.

E. Valeur, D. Roche, 2008 .

Rhodium(III)-catalyzed allylic C-H bond amination. Synthesis of cyclic amines from ω-unsaturated N-sulfonylamines.

J. Ortholand, J. Cossy, V. Bellosta, 2012, Chemical communications.

(E)‐Dimethyl 2‐Oxopent‐3‐enylphosphonate: An Excellent Substrate for Cross‐Metathesis – Easy Access to Functionalized Heterocycles

J. Cossy, V. Bellosta, D. Roche, 2012 .

N-Formylsaccharin: A New Formylating Agent

J. Cossy, V. Bellosta, D. Roche, 2011 .

Total syntheses of bengamides B and E.

M. Green, S. Zabludoff, K. Bair, 2001, The Journal of organic chemistry.

An improved procedure of the Pechmann condensation in the synthesis of 8-ethyltrimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-ones structurally related to the aglycon of gilvocarcins

D. Hua, D. Roche, S. Iguchi, 1992 .

Retention of Configuration in Displacement Reactions of 2-Chloro-1,3,2-oxazaphospholidin-2-one. Stereoselective 1,4-Addition Reaction of the Anion of Chiral 2-Propenylphosphonamide

D. Hua, P. Robinson, Hui Wang, 2002 .

Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.

D. Roche, A. Baron, A. Thys, 2011, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

E. Valeur, F. Schmidlin, Franck F. Lepifre, 2009, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of (4S,5R,6S)-4-(5,6-epoxy-6-phenyl)-γ-lactone

G. Bold, J. Fischer, A. Cian, 1996 .

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Claus Ehrhardt, Michael Sabio, Didier Roche, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of benzylated (R)- and as conformationally restricted building blocks for the preparation of E- and P-selectin antagonists

B. Ernst, F. Casset, T. Winkler, 1998 .

Effect of a Phosphazene Base on the Diastereoselectivity of Addition of alpha-Sulfonyl Carbanions to Butyraldehyde and Isopropylideneglyceraldehyde.

J. Fischer, D. Roche, A. Solladié-Cavallo, 1996, The Journal of organic chemistry.

An expedient synthesis of non-racemic N-alkylated pyrrolidin-2,5-diones and piperidin-2,6-diones as peptidomimetics

D. Roche, C. Lardy, J. Fournier, 2016 .

Mild and regioselective oxidative bromination of anilines using potassium bromide and sodium perborate

D. Roche, K. Prasad, O. Repič, 2000 .

Design and synthesis of potent and selective inhibitors of integrin VLA-4.

M. Sabio, M. Weetall, D. Roche, 2001, Bioorganic & medicinal chemistry letters.

Exploring new targets and chemical space with affinity selection-mass spectrometry

D. A. Annis, R. Prudent, J. Ortholand, 2020, Nature Reviews Chemistry.

Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.

Y. Hérault, L. Meijer, Thu Lan Nguyen, 2021, Journal of medicinal chemistry.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Christoph E. Dumelin, A. Keefe, O. Fedorov, 2017, ACS chemical biology.

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.

E. Thoreau, L. Chantalat, Kenny Mebrouk, 2018, Journal of Medicinal Chemistry.

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.

D. Musil, E. Valeur, F. Schmidlin, 2010, Bioorganic & medicinal chemistry letters.

New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.

E. Thoreau, L. Chantalat, M. Gastreich, 2017, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of (E)-N,N-diethyl-3-(imidazo[1,2-a]pyrid-2-yl)-2-(phenylsulfonyl)propenamide

V. Gaumet, D. Roche, M. Madesclaire, 2002 .

(Z)-Methyl 2-phenyl-2-(pyrid-4-yl)vinyl sulfoxide

D. Roche, A. Fauve, M. Madesclaire, 1990 .

Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.

L. Meijer, S. Knapp, Andreas Krämer, 2023, Journal of medicinal chemistry.

PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis

E. Valeur, D. Roche, C. Lardy, 2010 .