R. Lira

发表

Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.

S. Sakya, Kevin Ogilvie, Jason K. Dutra, 2013, The Journal of organic chemistry.

Palladium-catalyzed synthesis of N-aryl-2-benzylindolines via tandem arylation of 2-allylaniline: control of selectivity through in situ catalyst modification.

J. Wolfe, R. Lira, 2004, Journal of the American Chemical Society.

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

J. McKerrow, W. Roush, R. Lira, 2008, Bioorganic & medicinal chemistry letters.

Development of a Double Allylboration Reagent Targeting 1,5-syn-(E)-Diols: Application to the Synthesis of the C(23)-C(40) Fragment of Tetrafibricin.

W. Roush, R. Lira, P. Nuhant, 2011, Tetrahedron.

One-pot in situ formation and reaction of trimethyl(trichloromethyl)silane: application to the synthesis of 2,2,2-trichloromethylcarbinols.

R. Lira, K. Henegar, 2012, The Journal of organic chemistry.

Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane.

W. Roush, R. Lira, A. C. DeBaillie, 2009, Journal of the American Chemical Society.

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.

S. Webber, Amit M. Shah, R. Showalter, 2004, Bioorganic & medicinal chemistry letters.

Enantio- and diastereoselective synthesis of (E)-1,5-syn-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin.

W. Roush, R. Lira, P. Nuhant, 2011, Organic letters.

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.

S. Webber, Amit M. Shah, R. Showalter, 2007, Bioorganic & medicinal chemistry letters.

Transcription inactivation through local refolding of the RNA polymerase structure

E. Nudler, D. Vassylyev, I. Artsimovitch, 2009, Nature.

Structure-activity studies of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues.

T. Mcmorris, S. Waters, R. Lira, 2001, The Journal of organic chemistry.

Sesquiterpenes from Omphalotus illudens.

M. Kelner, T. Mcmorris, P. Gantzel, 2002, Phytochemistry.

Sesquiterpenes from Omphalotus illudens

M. Kelner, T. Mcmorris, P. Gantzel, 2003 .

Sesquiterpenes from the basidiomycete Omphalotus illudens.

M. Kelner, T. Mcmorris, P. Gantzel, 2000, Journal of natural products.

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.

K. Parris, K. Atchison, D. Riddell, 2015, Journal of medicinal chemistry.

Cross-linked poly-4-acrylomorpholine: a flexible and reversibly compressible aligning gel for anisotropic NMR analysis of peptides and small molecules in water.

R. Gil, Martin R. M. Koos, R. Horst, 2021, Angewandte Chemie.

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

J. Pandit, K. Parris, Eric F. Johnson, 2015, Journal of medicinal chemistry.

Chronic exposure to arsenite enhances influenza virus infection in cultured cells

W. Klimecki, R. Lira, E. Amouzougan, 2020, Journal of applied toxicology : JAT.

Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19

David W. Place, Brian P. Jones, J. Mousseau, 2023, Organic process research & development.

Process Development and Scale-up of a β-Secretase Inhibitor via a Stereospecific Jocic Reaction

J. González-Hernández, R. Lira, K. Henegar, 2013 .

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Gregory W. Kauffman, L. Pustilnik, S. Sakya, 2012, Bioorganic & medicinal chemistry letters.

Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

K. Parris, Eric F. Johnson, S. Sakya, 2015 .

Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin.

W. Roush, R. Lira, 2007, Organic letters.