B. O’Neill

发表

Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.

S. Sakya, Kevin Ogilvie, Jason K. Dutra, 2013, The Journal of organic chemistry.

Total synthesis of (+/-)-cytisine.

D. Yohannes, B. O’Neill, M. Bundesmann, 2000, Organic letters.

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Brian T. O’Neill, Yi Lu, Huang Jianhua, 2005 .

Total synthesis of quinocarcinol methyl ester

S. Danishefsky, R. Webb, B. O’Neill, 1985 .

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.

F. Tingley, H. Rollema, B. O’Neill, 2005, Bioorganic & medicinal chemistry letters.

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.

F. Tingley, H. Rollema, B. O’Neill, 2005, Bioorganic & medicinal chemistry letters.

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

F. Tingley, H. Rollema, B. O’Neill, 2005 .

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.

R. J. Mather, C. J. O’Donnell, Frank M Nedza, 2009, Bioorganic & medicinal chemistry letters.

Cerebrospinal Fluid β-Amyloid Turnover in the Mouse, Dog, Monkey and Human Evaluated by Systematic Quantitative Analyses

É. Hajós‐Korcsok, D. Riddell, H. Barton, 2012, Neurodegenerative Diseases.

An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles.

S. Buchwald, B. O’Neill, Vasudev R. Bhonde, 2016, Angewandte Chemie.

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.

F. Tingley, J. Heym, H. Rollema, 2005, Journal of medicinal chemistry.

P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists.

S. Kajiji, A. Doran, S. Mclean, 2001, The Journal of pharmacology and experimental therapeutics.

A novel BACE inhibitor (PF-05297909): A two-part adaptive design to evaluate safety, pharmacokinetics and pharmacodynamics for modifying beta-amyloid in a first-in-human study

Kaori Ito, T. Nicholas, É. Hajós‐Korcsok, 2013, Alzheimer's & Dementia.

&agr;4&bgr;2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Y. Mineur, M. Picciotto, P. Seymour, 2011, Behavioural pharmacology.

Nucleophilic Addition to Carboxylic Acid Derivatives

B. O’Neill, 1991 .

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry.

M. Tran-Dube, J. Warmus, M. Collins, 2015, The Journal of organic chemistry.

Pyridine analogs of (−)-cytisine and varenicline: cholinergic receptor probes

B. O’Neill, E. Arnold, J. Coe, 2008 .

Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine.

D. Yohannes, B. O’Neill, L. Lebel, 2008, Bioorganic & medicinal chemistry letters.

Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides.

G. Molander, K. M. Traister, B. O’Neill, 2015, The Journal of organic chemistry.

Diastereoselective synthesis of 2,3,6-trisubstituted piperidines.

N. J. Tom, John B Feltenberger, A. Nagel, 2009, The Journal of organic chemistry.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

R. J. Mather, Anne W. Schmidt, R. Hurst, 2010, Journal of medicinal chemistry.

Reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl and heteroaryl bromides.

G. Molander, K. M. Traister, B. O’Neill, 2014, The Journal of organic chemistry.

Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation.

B. O’Neill, J. Murray, M. Bundesmann, 2017, The Journal of organic chemistry.

A convergent process to C-2 substituted peneme via addition of thiols and organocuprates to an O-triflylthioketene acetal

D. Phillips, B. O’Neill, 1990 .

Chapter 13 – An Industrial Perspective on Total Synthesis; Penem Antibacterial CP-70,429

R. Volkmann, B. O’Neill, 1991 .

Tandem Michael addition and azanorbornane substance-P antagonists

P. Thadeio, S. Mclean, A. Elder, 1997 .

A reinvestigation and improvement in the synthesis of meso-2,5-dibromoadipates by application of Le Chatelier's principle

B. O’Neill, H. Watson, 1990 .

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

F. Tingley, H. Rollema, B. O’Neill, 2005 .

Tachykinin NK1 receptor antagonists for the control of chemotherapy-induced nausea and vomiting

J. Gale, J. Humphrey, B. O’Neill, 2001 .

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Graham M. West, Sherry L. Niessen, Claude Ambroise, 2016, Nature Communications.

Chapter 4 Case History: Chantix™/Champix™ (Varenicline Tartrate), a Nicotinic Acetylcholine Receptor Partial Agonist as a Smoking Cessation Aid

H. Rollema, B. O’Neill, J. Coe, 2009 .

Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses

É. Hajós‐Korcsok, K. Bales, D. Riddell, 2012, Journal of Pharmacology and Experimental Therapeutics.

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

Claude Ambroise, D. Karanian, K. Bales, 2018, Journal of medicinal chemistry.

Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.

É. Hajós‐Korcsok, Claude Ambroise, K. Borzilleri, 2012, Journal of medicinal chemistry.

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.

K. Parris, K. Atchison, D. Riddell, 2015, Journal of medicinal chemistry.

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

J. Pandit, K. Parris, Eric F. Johnson, 2015, Journal of medicinal chemistry.

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

K. Parris, Eric F. Johnson, K. Atchison, 2016, Journal of medicinal chemistry.

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

B. O’Neill, M. Lall, M. Burns, 2021 .

Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

K. Parris, Eric F. Johnson, S. Sakya, 2015 .

Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain

C. Halldin, L. Chen, A. Takano, 2018, The Journal of Nuclear Medicine.

Quantitative Analysis of 18 F-PF-06684511, a Novel PET Radioligand for Selective β-secretase 1 Imaging, in Non-human Primate Brain

C. Halldin, L. Chen, A. Takano, 2018 .

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

J. Heym, H. Rollema, B. O’Neill, 2005 .

Engaging nonaromatic, heterocyclic tosylates in reductive cross-coupling with aryl and heteroaryl bromides.

G. Molander, K. M. Traister, B. O’Neill, 2015, The Journal of organic chemistry.