F. Yokokawa

发表

Recent progress on the discovery of non-peptidic direct renin inhibitors for the clinical management of hypertension

F. Yokokawa, 2013, Expert opinion on drug discovery.

Recent advances in the discovery of non-peptidic direct renin inhibitors as antihypertensives: new patent applications in years 2000 – 2008

J. Maibaum, F. Yokokawa, 2008 .

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, Antimicrobial Agents and Chemotherapy.

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, bioRxiv.

An expeditious synthesis of pentosidine, an advanced glycation end product

F. Yokokawa, T. Shioiri, H. Ogawa, 2001 .

Recent progress on phenotype-based discovery of dengue inhibitors.

F. Yokokawa, 2020, RSC medicinal chemistry.

Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

N. Ostermann, T. Kanazawa, D. Rigel, 2014, ACS medicinal chemistry letters.

Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels

W. Gerwick, T. F. Murray, T. Okino, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation.

P. Wipf, J. Lazo, F. Yokokawa, 1997, Biochemistry.

Total synthesis of (−)-hennoxazole A

F. Yokokawa, T. Shioiri, T. Asano, 2001 .

Total synthesis of the antiviral marine natural product (-)-hennoxazole A.

F. Yokokawa, T. Shioiri, T. Asano, 2000, Organic letters.

Synthetic studies toward diazonamide A. Preparation of the benzofuranone-indolyloxazole fragment

P. Wipf, F. Yokokawa, 1998 .

The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons.

W. Gerwick, T. F. Murray, T. Asano, 2005, Toxicology letters.

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening*

Paul W Smith, P. Shi, S. Lim, 2016, The Journal of Biological Chemistry.

An efficient synthesis of C20–C25 building blocks for calyculin A

Y. Hamada, F. Yokokawa, K. Hatano, 1996 .

Synthesis of the tetraene fragment of calyculins having natural configurations

Y. Hamada, F. Yokokawa, T. Shioiri, 1993 .

Stereoselective Synthesis of 2,3-dihydroxy-4-dimethylamino-5-methoxypentanoic acid, a fragment of calyculins ------- determination of the absolute configuration of calyculins☆

Y. Hamada, F. Yokokawa, T. Shioiri, 1991 .

Total syntheses of lyngbyabellins A and B, potent cytotoxic lipopeptides from the marine cyanobacterium Lyngbya majuscula

D. Katagiri, F. Yokokawa, T. Shioiri, 2002 .

Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.

S. Bevan, K. Tanabe, S. Koizumi, 2008, Journal of medicinal chemistry.

Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies

Yen-Liang Chen, P. Shi, J. Lescar, 2020, Journal of Virology.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

K. Mansfield, W. Zhong, M. Fenaux, 2016, Antimicrobial Agents and Chemotherapy.

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.

Yen-Liang Chen, W. Zhong, P. Shi, 2018, Bioorganic & medicinal chemistry letters.

Characterization of the preferred stereochemistry for the neuropharmacologic actions of antillatoxin.

W. Gerwick, T. F. Murray, T. Okino, 2004, Journal of natural products.

Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium Lyngbya majuscula

W. Gerwick, R. Williamson, T. F. Murray, 2000 .

A conserved metabolic signature associated with response to fast-acting antimalarial agents

M. Barrett, A. Waters, C. Regnault, 2022, bioRxiv.

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2.

S. Bevan, T. Kanazawa, M. Malcangio, 2008, Bioorganic & medicinal chemistry letters.

The search for nucleoside/nucleotide analog inhibitors of dengue virus.

Yen-Liang Chen, P. Shi, F. Yokokawa, 2015, Antiviral research.

Synthesis of the C26-C37 fragment of calyculin A having natural configuration

Y. Hamada, F. Yokokawa, T. Shioiri, 1992 .

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

Shi Hua Ang, Paul W Smith, K. Kuhen, 2013, ACS medicinal chemistry letters.

Novel stereospecific dehydration of β-hydroxy-α-amino acids using Martin's sulfurane

F. Yokokawa, T. Shioiri, 2002 .

Total Synthesis of Antillatoxin, an Ichthyotoxic Cyclic Lipopeptide, Having the Proposed Structure. What Is the Real Structure of Antillatoxin?

F. Yokokawa, T. Shioiri, 1998 .

Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide

F. Yokokawa, T. Shioiri, 2002 .

Total synthesis of mycothiazole, a polyketide heterocycle from marine sponges

F. Yokokawa, T. Shioiri, H. Sugiyama, 2003 .

Total synthesis and conformational studies of ceratospongamide, a bioactive cyclic heptapeptide from marine origin

T. Ishida, F. Yokokawa, T. Shioiri, 2002 .

Synthetic studies of N-reverse prenylated indole. An efficient synthesis of antifungal indole alkaloids and N-reverse prenylated tryptophan

F. Yokokawa, T. Shioiri, H. Sugiyama, 2001 .

Total synthesis of lyngbyabellin A, a potent cytotoxic metabolite from the marine cyanobacterium Lyngbya majuscula

F. Yokokawa, T. Shioiri, H. Sameshima, 2001 .

Asymmetric total synthesis of (-)-mycothiazole.

F. Yokokawa, T. Shioiri, H. Sugiyama, 2000, Organic letters.

An expeditious total synthesis of kalkitoxins: determination of the absolute stereostructure of natural kalkitoxin

W. Gerwick, T. Okino, F. Yokokawa, 2004 .

Syntheses of four unusual amino acids, constituents of cyclomarin A

Fumiaki Yokokawa, F. Yokokawa, T. Shioiri, 2002 .

Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

F. Yokokawa, T. Shioiri, Akiko Inaizumi, 2005 .

Synergistic Suppression of Dengue Virus Replication Using a Combination of Nucleoside Analogs and Nucleoside Synthesis Inhibitors

Yen-Liang Chen, P. Shi, Qing-yin Wang, 2015, Antimicrobial Agents and Chemotherapy.

Ten years of dengue drug discovery: progress and prospects.

David Beer, Hongping Dong, Shahul Nilar, 2013, Antiviral research.

Synthesis of 2,4-Disubstituted Oxazoles

Y. Hamada, F. Yokokawa, T. Shioiri, 1992 .

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

G. Bonamy, V. Sasseville, Yen-Liang Chen, 2021, Science Translational Medicine.

Disruption of Insulin-Like Growth Factor-1 Signaling and Down-Regulation of Cdc2 by SC-ααδ9, a Novel Small Molecule Antisignaling Agent Identified in a Targeted Array Library

P. Wipf, J. Lazo, A. Vogt, 1998 .

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Hongping Dong, Rishi Arora, Xuping Xie, 2016, PLoS pathogens.

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.

Paul W Smith, P. Shi, R. Rao, 2016, Journal of medicinal chemistry.

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides.

Yen-Liang Chen, P. Shi, R. Pohl, 2012, Bioorganic & medicinal chemistry.

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

F. Gamo, E. Fang, Yen-Liang Chen, 2022, Journal of medicinal chemistry.

A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo

David C. Chang, L. Kramer, Xuping Xie, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.

P. Shi, S. Lim, S. Nilar, 2018, Advances in experimental medicine and biology.

4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors.

T. Kanazawa, H. Hirao, K. Masuya, 2008, Bioorganic & medicinal chemistry letters.

Discovery of selective and nonpeptidic cathepsin S inhibitors.

T. Kanazawa, C. Snell, H. Hirao, 2008, Bioorganic & medicinal chemistry letters.

Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide

F. Yokokawa, T. Shioiri, Akiko Inaizumi, 2001 .

Synthetic Studies of Micropeptin T-20, a Novel 3-Amino-6-hydroxy-2-piperidone (Ahp)-Containing Cyclic Depsipeptide.

F. Yokokawa, T. Shioiri, Akiko Inaizumi, 2001 .

Total Synthesis of cis,cis-Ceratospongamide, a Bioactive Thiazole-Containing Cyclic Peptide from Marine Origin

F. Yokokawa, T. Shioiri, H. Sameshima, 2001 .

Total Synthesis and Revision of Absolute Stereochemistry of Antillatoxin, an Ichthyotoxic Cyclic Lipopeptide from Marine Cyanobacterium Lyngbya majuscula

F. Yokokawa, T. Shioiri, H. Fujiwara, 2000 .

Total synthesis and revision of absolute configuration of antillatoxin, an ichthyotoxic cyclic lipopeptide of marine origin

F. Yokokawa, T. Shioiri, H. Fujiwara, 1999 .

Synthesis of a Potent Pan-Serotype Dengue Virus Inhibitor Having a Tetrahydrothienopyridine Core

B. Yeung, Lei Zhang, F. Yokokawa, 2020, Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry.

Total Synthesis of Amamistatin A, an Antiproliferative Linear Peptide from an Actinomycete

F. Yokokawa, T. Shioiri, Kentaro Izumi, 2000 .

Total Synthesis of Amamistatin A, an Antiproliferative Linear Peptide from an Actinomycete.

F. Yokokawa, T. Shioiri, Kentaro Izumi, 2000 .

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.

G. Bonamy, Qing-yin Wang, Hongping Dong, 2017, Bioorganic & medicinal chemistry letters.

Efficient total synthesis of pentosidine, an advanced glycation endproduct

F. Yokokawa, T. Shioiri, H. Ogawa, 1999 .

Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array.

P. Wipf, J. Lazo, F. Yokokawa, 2000, Bioorganic & medicinal chemistry.

Ten years of dengue drug discovery: progress and prospects.

Paul W Smith, Yen-Liang Chen, P. Shi, 2013, Antiviral research.

A General Synthesis of N-Reverse-Prenyl Indoles.

F. Yokokawa, H. Sugiyama, T. Aoyama, 2004 .