Austin Chen

发表

The discovery and synthesis of potent zwitterionic inhibitors of renin.

J. Falgueyret, M. Percival, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Exploring Biomarkers of Coronary Heart Disease from Gene and MicroRNA Expression Profiles

P. Hong, Austin Chen, Shue Huang, 2014 .

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Rebecca T. Ruck, Yongxin Han, J. Howe, 2016, ACS medicinal chemistry letters.

In vitro and in vivo pharmacology of NXT629, a novel and selective PPAR&agr; antagonist☆

D. Lorrain, P. Prasit, D. Messmer, 2017, European journal of pharmacology.

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Yongxin Han, S. Gagné, Y. Ducharme, 2011, Bioorganic & medicinal chemistry letters.

3,4-Diarylpiperidines as potent renin inhibitors.

J. Falgueyret, Yongxin Han, E. Cauchon, 2012, Bioorganic & medicinal chemistry letters.

Identification of a new biaryl scaffold generating potent renin inhibitors.

C. Bayly, D. McKay, R. Aspiotis, 2010, Bioorganic & medicinal chemistry letters.

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.

S. Gagné, D. McKay, E. Grimm, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of potent, isoxazole-containing renin inhibitors.

J. Falgueyret, M. Percival, Yongxin Han, 2012, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.

J. Falgueyret, Yongxin Han, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.

C. Bayly, S. Gagné, S. Soisson, 2010, Bioorganic & medicinal chemistry letters.

Palladium-catalyzed double allylic alkylation of indole-2-hydroxamates: easy access to pyrazino[1,2-a]indole derivatives

Sébastien Laliberté, Austin Chen, P. Dornan, 2010 .

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

D. Lorrain, Xiao-Jie Yan, N. Chiorazzi, 2015, Molecular medicine.

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

D. Lorrain, P. Prasit, B. Laffitte, 2019, Bioorganic & medicinal chemistry letters.

Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Antitumor Activity Against Prostaglandin-Expressing Tumors

P. Prasit, D. Panigrahy, D. Wang, 2023, Cancer research communications.

Identification of the first potent, selective and bioavailable PPARα antagonist.

D. Lorrain, P. Prasit, D. Messmer, 2014, Bioorganic & medicinal chemistry letters.