B. Steiner

发表

Design and optimization of new piperidines as renin inhibitors.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Journal of medicinal chemistry.

New classes of potent and bioavailable human renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Bioorganic & medicinal chemistry letters.

Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling.

M. Bolli, O. Nayler, B. Steiner, 2014, Cellular signalling.

Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via

M. Bolli, O. Nayler, B. Steiner, 2013 .

Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P2 and S1P3 Receptors and Smad-independent Signaling

M. Bolli, O. Nayler, B. Steiner, 2013, The Journal of Biological Chemistry.

Trans-dominant inhibition of integrin function.

M. Ginsberg, M. Ginsberg, J. Forsyth, 1996, Molecular biology of the cell.

Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial.

R. Califf, E. Topol, P. Armstrong, 1998, Journal of the American College of Cardiology.

Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIbα

H. Deckmyn, H. Ulrichts, L. Pontiggia, 2006, Thrombosis and Haemostasis.

Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.

P. Hadváry, D. Knopp, S. Bunting, 1996, Journal of medicinal chemistry.

Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor.

P. Hadváry, D. Kirchhofer, L. Jennings, 1992, Blood.

Renin inhibitors: An antihypertensive strategy on the verge of reality

G. Feuerstein, W. Fischli, B. Steiner, 2005 .

Effects of GP IIb/IIIa receptor antagonists on the activating clotting time of heparinized blood.

J. Himber, B. Steiner, L. Burckien, 2000, Blood.

Platelet membrane receptor glycoprotein IIb/IIIa antagonism in unstable angina. The Canadian Lamifiban Study.

P. Théroux, M. Knudtson, A. Fung, 1996, Circulation.

Glycocalicin: a new assay--the normal plasma levels and its potential usefulness in selected diseases.

J. Beer, B. Steiner, L. Büchi, 1994, Blood.

Blockade of Platelet GPIIB-IIIA (Integrin αIIbβ3) in Flowing Human Blood Leads to Passivation of Prothrombotic Surfaces

M. Ginsberg, M. Riederer, B. Steiner, 2002, Thrombosis and Haemostasis.

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.

J. Rosa, B. Steiner, Y. Chen, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The integrin alpha IIb-beta 3, platelet glycoprotein IIb-IIIa, can form a functionally active heterodimer complex without the cysteine-rich repeats of the beta 3 subunit.

P. Hadváry, J. Wippler, H. Kuhn, 1994, The Journal of biological chemistry.

Blocking platelet aggregation inhibits thromboxane A2 formation by low dose agonists but does not inhibit phosphorylation and activation of cytosolic phospholipase A2.

R. Carroll, F. Lanza, B. Steiner, 1997, Thrombosis research.

Dissociation of Antithrombotic Effect and Bleeding Time Prolongation in Rabbits by Inhibiting Tissue Factor Function

D. Kirchhofer, J. Himber, M. Riederer, 1997, Thrombosis and Haemostasis.

S1P1 Modulator-Induced Gαi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

R. de Kanter, M. Bolli, C. Kohl, 2018, Molecular Pharmacology.

Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties

N. Schmitz, M. Bolli, M. Clozel, 2017, Pharmacology research & perspectives.

Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

M. Percival, D. Riendeau, W. Cromlish, 2011, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Thrombin binding to GPIbα induces platelet aggregation and fibrin clot retraction supported by resting αIIbβ3 interaction with polymerized fibrin

N. Kieffer, C. Dubois, B. Steiner, 2003, Thrombosis and Haemostasis.

Effects of heparin, aspirin and a synthetic platelet glycoprotein IIb-IIIa receptor antagonist (Ro 43-5054) on coronary artery reperfusion and reocclusion after thrombolysis with tissue-type plasminogen activator in the dog.

P. Hadváry, S. Roux, H. Kuhn, 1993, The Journal of pharmacology and experimental therapeutics.

Evidence for novel binding sites on the platelet glycoprotein IIb and IIIa subunits and immobilized fibrinogen.

L. Parise, D. Phillips, B. Steiner, 1993, The Biochemical journal.

Contribution of PAR-1, PAR-4 and GPIbα in intracellular signaling leading to the cleavage of the β3 cytoplasmic domain during thrombin-induced platelet aggregation

C. Dubois, B. Steiner, S. Meyer Reigner, 2004, Thrombosis and Haemostasis.

Pharmacokinetics, Pharmacodynamics and Tolerability of a Potent, Non-peptidic, GP IIb/IIIa Receptor Antagonist following Multiple Oral Administrations of a Prodrug Form

S. Bunting, M. Beresini, K. Robarge, 1998, Thrombosis and Haemostasis.

Therapeutic Use of a Selective S1P1 Receptor Modulator Ponesimod in Autoimmune Diabetes

L. Chatenoud, J. Bach, S. You, 2013, PloS one.

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa.

P. Hadváry, B. Steiner, W. Kouns, 1992, The Journal of biological chemistry.

Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.

M. Bolli, Stefan Abele, A. Treiber, 2013, Journal of medicinal chemistry.

Low molecular weight, non-peptide fibrinogen receptor antagonists.

P. Hadváry, A. Trzeciak, D. Knopp, 1992, Journal of medicinal chemistry.

The Selective Sphingosine 1-Phosphate Receptor 1 Agonist Ponesimod Protects against Lymphocyte-Mediated Tissue Inflammation

M. Bolli, M. Clozel, S. Froidevaux, 2011, Journal of Pharmacology and Experimental Therapeutics.

Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P1 Receptor Modulator

M. Clozel, S. Delahaye, O. Nayler, 2013, PloS one.

Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis.

M. Martinic, C. Bernard, M. Clozel, 2019, Innovations in clinical neuroscience.

Platelet membrane glycoprotein IIb-IIIa complex: purification, characterization, and reconstitution into phospholipid vesicles.

L. Parise, D. Phillips, L. Fitzgerald, 1992, Methods in enzymology.

Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.

Stimulation of platelet glycoprotein IIb‐IIIa (αIIbβ3‐integrin) functional activity by a monoclonal antibody to the N‐terminal region of glycoprotein IIIa

O. Tikhomirov, M. Berndt, B. Steiner, 1996 .

Stimulation of platelet glycoprotein IIb-IIIa (alpha IIb beta 3-integrin) functional activity by a monoclonal antibody to the N-terminal region of glycoprotein IIIa.

T. Byzova, M. Berndt, B. Steiner, 1996, FEBS letters.

Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.

L. Parise, D. Phillips, B. Steiner, 1987, The Journal of biological chemistry.

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.

Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

I. Charo, D. Phillips, S. C. Rall, 1986, Proceedings of the National Academy of Sciences of the United States of America.

a potent and selective peptidomimetic inhibitor Reversible conformational changes induced in glycoprotein IIb-IIIa by

P. Hadváry, D. Kirchhofer, B. Steiner, 2011 .

Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia.

L. Jennings, J. Cazenave, F. Lanza, 1994, Blood.

Evidence fornovel binding sites ontheplatelet glycoprotein lIbandIlila subunits andimmobilized fibrinogen

B. Steiner, 1993 .

Tetrafibricin, a novel non-peptide fibrinogen receptor antagonist, induces conformational changes in glycoprotein IIb/IIIa.

B. Steiner, T. Kamiyama, W. Kouns, 1994, The Biochemical journal.

Role of collagen-adherent platelets in mediating fibrin formation in flowing whole blood.

D. Kirchhofer, H. Baumgartner, T. Tschopp, 1995, Blood.

Ca2+-dependent binding of a synthetic Arg-Gly-Asp (RGD) peptide to a single site on the purified platelet glycoprotein IIb-IIIa complex.

P. Hadváry, A. Trzeciak, D. Gillessen, 1989, The Journal of biological chemistry.

Ro 44-9883, a New Non-Peptidic GPIIb-GPIIIa Antagonist Prevents Platelet Loss in a Guinea Pig Model of Extracorporeal Circulation

S. Roux, J. Carteaux, B. Steiner, 1993, Thrombosis and Haemostasis.

The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions.

N. Kieffer, S. Kreis, B. Steiner, 2005, Experimental cell research.

Piperidine-based renin inhibitors: upper chain optimization.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.

D. Renneberg, M. Riederer, E. Meyer, 2015, Journal of medicinal chemistry.

Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.

R. de Kanter, M. Bolli, Stefan Abele, 2014, Journal of medicinal chemistry.

Isolation and characterization of glycoprotein Ib.

K. Clemetson, B. Steiner, J. Clemetson, 1992, Methods in enzymology.

Improvement of the periodate-borohydride surface-labeling method for human blood platelets.

K. Clemetson, E. Lüscher, B. Steiner, 1983, Thrombosis research.

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin".

S. Lo, D. Phillips, S. C. Rall, 1987, The Journal of biological chemistry.

Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy.

H. Erickson, D. Phillips, H P Erickson, 1985, The Journal of biological chemistry.

Stable expression in Chinese hamster ovary cells of a homogeneous recombinant active fragment of human platelet glycoprotein Ibα

E. Schlaeger, B. Steiner, B. Schumpp-Vonach, 2004, Cytotechnology.

Fine structural and functional consequences of deglycosylation of the platelet adhesion receptor GPIb-IX (CD 42b).

U. Aebi, J. Beer, B. Steiner, 1998, Biochemical and biophysical research communications.

Quantitation of platelet‐specific autoantibodies in platelet eluates of ITP patients measured by a novel ELISA using the purified glycoprotein complexes GPIIb/IIIa and GPIb/IX as antigens

B. Steiner, A. von Felten, Marianne Hürlimann‐Forster, 1997, British journal of haematology.

Peptides derived from a sequence within beta 3 integrin bind to platelet alpha IIb beta 3 (GPIIb-IIIa) and inhibit ligand binding.

A. Trzeciak, B. Steiner, W. Kouns, 1993, The Journal of biological chemistry.

The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions

N. Kieffer, S. Kreis, B. Steiner, 2005 .

Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.

R. de Kanter, M. Bolli, C. Kohl, 2014, Journal of medicinal chemistry.

Plasma autoantibodies against platelet glycoprotein IIb/IIIa from patients with autoimmune thrombocytopenic purpura may recognize different antigenic determinants

D. Müller, B. Steiner, P. Berchtold, 1998, European journal of haematology.

Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

M. Poncz, J. Bennett, D. Phillips, 1987, Biochemistry.

Expression and characterization of functionally active fragments of the platelet glycoprotein (GP) Ib-IX complex in mammalian cells. Incorporation of GP Ib alpha into the cell surface membrane.

P. Hadváry, S. Meyer, K. Clemetson, 1993, The Journal of biological chemistry.

Evidence that the platelet plasma membrane does not contain a (Ca2+ + Mg2+)-dependent ATPase.

E. Lüscher, B. Steiner, 1985, Biochimica et biophysica acta.

Tetrafibricin: a nonpeptidic fibrinogen receptor inhibitor from Streptomyces neyagawaensis (I). Its GPIIb/IIIa blockage on solid phase binding assay.

P. Hadváry, M. Arisawa, B. Steiner, 1993, Thrombosis research.

Platelet Surface Activation Markers after DDAVP Infusion in Healthy Subjects

W. Haefeli, L. Linder, B. Steiner, 1995, Thrombosis and Haemostasis.

Fibrinogen receptor antagonists - a novel class of promising antithrombotics

L. Alig, M. Müller, B. Steiner, 1994 .

Contamination of coagulation factor concentrates with human parvovirus B19 genotype 1 and 2

C. Dubois, M. Riederer, B. Steiner, 2004 .

The reversible P2Y12 antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat

M. Riederer, M. Clozel, P. Hess, 2017, Pharmacology research & perspectives.

Determination of kinetic constants for the interaction between the platelet glycoprotein IIb-IIIa and fibrinogen by means of surface plasmon resonance.

W. Huber, D. Schlatter, B. Steiner, 1995, European journal of biochemistry.

Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.

T. O’Toole, C. Abrams, S. Shattil, 1994, The Journal of biological chemistry.

Establishment of Solid Phase GPIIb/IIIa Binding Assay Using Biotinylated Fibrinogen as a Ligand

P. Hadváry, M. Arisawa, B. Steiner, 1991 .

Ca(2+)-dependent structural transitions of the platelet glycoprotein IIb-IIIa complex. Preparation of stable glycoprotein IIb and IIIa monomers.

L. Parise, D. Phillips, B. Steiner, 1991, The Journal of biological chemistry.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.

R. de Kanter, M. Bolli, C. Kohl, 2016, European journal of medicinal chemistry.