J. Edmunds

发表

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors.

N. Powell, D. Downing, M. Jalaie, 2005, Bioorganic & medicinal chemistry.

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.

A Versatile Copper-Catalyzed Coupling Reaction of Pyridin-2(1H)-ones with Aryl Halides.

A. Casimiro-Garcia, K. J. Filipski, D. Dudley, 2006 .

Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization.

N. Powell, D. Downing, W. L. Cody, 2004, Organic letters.

Progress in the discovery of Factor Xa inhibitors

A. Casimiro-Garcia, C. Bigge, K. J. Filipski, 2006 .

1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists

A. Doherty, J. Edmunds, M. Flynn, 1996 .

1,3-DIARYL-2-CARBOXYINDOLES AS POTENT NON-PEPTIDE ENDOTHELIN ANTAGONISTS

A. Doherty, J. Edmunds, M. Flynn, 1996 .

An Expeditious Synthesis of 6-Alkyl-5-(4′-amino-phenyl)-pyrimidine-2,4-diamines

D. Holsworth, S. Maiti, J. Edmunds, 2003 .

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

N. Powell, M. J. Ryan, E. Zhang, 2007, Bioorganic & medicinal chemistry.

Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.

N. Powell, M. J. Ryan, M. Jalaie, 2005, Bioorganic & medicinal chemistry letters.

Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors.

P. Winocour, J. Edmunds, M. A. Siddiqui, 2002, Bioorganic & medicinal chemistry letters.

Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues.

J. Rubin, P. Winocour, J. Edmunds, 2001, Bioorganic & medicinal chemistry letters.

Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.

D. B. Duignan, P. Honore, S. Mittelstadt, 2015, Journal of medicinal chemistry.

ffi cacy in a Rodent Model of Arthritis

D. B. Duignan, P. Honore, S. Mittelstadt, 2014 .

Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.

D. B. Duignan, P. Honore, S. Mittelstadt, 2015, Journal of medicinal chemistry.

Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors.

D. R. Holland, L. Chi, T. Mertz, 2000, Journal of medicinal chemistry.

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.

M. Adler, M. Whitlow, E. Zhang, 2005, Bioorganic & medicinal chemistry letters.

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.

M. Adler, M. Whitlow, E. Zhang, 2006, Bioorganic & Medicinal Chemistry Letters.

In Vitro and In Vivo Antithrombotic Activity of PD-198961, a Novel Synthetic Factor Xa Inhibitor

L. Chi, T. Mertz, J. Edmunds, 2004, Journal of cardiovascular pharmacology.

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

K. J. Filipski, W. L. Cody, J. Edmunds, 2000 .

The discovery of glycine and related amino acid-based factor Xa inhibitors.

Mostofa A Hena, V. Sahasrabudhe, E. Zhang, 2006, Bioorganic & medicinal chemistry.

Chapter 6. Thrombin and Factor Xa Inhibition

J. Edmunds, S. Rapundalo, 1996 .

Structure‐based Drug Design of Pyrrolidine‐1, 2‐dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

E. Zhang, Tom McClanahan, A. Casimiro-Garcia, 2007, Chemical biology & drug design.

The Discovery of (2R,4R)‐N‐(4‐chlorophenyl)‐N‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2H)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

L. Chi, E. Zhang, Tom McClanahan, 2007, Chemical biology & drug design.

Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.

D. R. Holland, L. Chi, T. Mertz, 2004, Journal of medicinal chemistry.

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.

Kevin J Filipski, Igor Mochalkin, V. Sahasrabudhe, 2009, Bioorganic & medicinal chemistry.

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.

D. R. Holland, J. DiMaio, A. Doherty, 1999, Bioorganic & medicinal chemistry letters.

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.

D. R. Holland, J. DiMaio, A. Doherty, 1998, Bioorganic & medicinal chemistry letters.

Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.

J. DiMaio, A. Doherty, J. Rubin, 1998, Bioorganic & medicinal chemistry letters.

Fluorination of sulfanyl amides using difluoroiodoarene reagents

J. Steed, M. Greaney, W. Motherwell, 2002 .

Observations on the reaction of some electron rich dienes with hypervalent iodoarene difluorides: a novel mechanism for fluorination

W. Motherwell, J. Edmunds, 1989 .

Stereocontrolled synthesis of calyculin A: construction of the C(1)–C(14) tetraene nitrile unit

A. Barrett, C. Parkinson, K. Horita, 1992 .

Stereocontrolled synthesis of calyculin A: construction of the C(15)–C(25) spiroketal unit

A. Barrett, C. Parkinson, K. Horita, 1992 .

Stereocontrolled synthesis of calyculin A: construction of the C(26)–C(37) amide-oxazole unit

J. Malecha, A. Barrett, C. Parkinson, 1992 .

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

A. Doherty, J. Bryant, J. Edmunds, 1998, Bioorganic & medicinal chemistry.

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

A. Doherty, A M Doherty, W C Patt, 1995, Journal of medicinal chemistry.

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.

A. Doherty, J. Rubin, P. Winocour, 1999, Bioorganic & medicinal chemistry letters.

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

A. Doherty, J. Keiser, H. Hallak, 1997, Journal of medicinal chemistry.

Synthesis of 4‐(R)‐Naphthalene‐2‐yloxy‐1‐(1‐Phenyl‐(S)‐Ethyl)‐Pyrrolidin‐3‐(R)‐ol and 4‐(S)‐Naphthalen‐2‐yloxy‐1‐(1‐Phenyl‐(S)‐Ethyl)‐Pyrrolidin‐3‐(S)‐ol: Versatile Chiral Intermediates for Synthesis

D. Holsworth, M. Stier, S. Maiti, 2004 .

Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A

J. Malecha, A. Barrett, C. Parkinson, 2001 .

Optimization of a Pd-catalyzed intramolecular α-arylation synthesis of tricyclo-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones

N. Powell, R. Kennedy, F. Ciske, 2010 .

Design and synthesis of tricyclic cores for kinase inhibition.

Brian J. Kotecki, Philip J. Merta, S. Shekhar, 2013, Bioorganic & medicinal chemistry letters.

Stereocontrolled Synthesis of Calyculin A: Construction of the C(1)-C( 14) Tetraene Nitrile Unit.

A. Barrett, C. Parkinson, K. Horita, 1992 .

Stereocontrolled Synthesis of Calyculin A: Construction of the C(15)-C( 25) Spiroketal Unit.

A. Barrett, C. Parkinson, K. Horita, 1992 .

Stereocontrolled Synthesis of Calyculin A: Construction of the C(26)-C( 37) Amide-Oxazole Unit.

J. Malecha, A. Barrett, C. Parkinson, 1992 .

Synthesis of benzocycloheptenones by 1,3-dipolar additions of 2-(1,3-benzodioxol-5-ylmethyl)-4-hydroxy-3-methoxy-carbonylisoquinolin-2-ium chloride with dipolarophiles

J. Edmunds, B. Tobias, Xue-Min Cheng, 1996 .

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

J. M. Hamby, R. Panek, J. C. Hodges, 1995, Journal of medicinal chemistry.

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.

P. Winocour, J. Edmunds, J J Edmunds, 2001, Bioorganic & medicinal chemistry letters.

Anti‐Inflammatory and Immunomodulatory Drugs

J. Edmunds, 2013 .

Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

Lu Wang, David B Duignan, D. B. Duignan, 2018, PloS one.

Medicinal Chemistry of AT2 Receptors

J. C. Hodges, J. Edmunds, 1994 .

Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

J. Ohren, A. Geyer, A. Casimiro-Garcia, 2011, Journal of medicinal chemistry.

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors.

Ana L. Aguirre, E. Tarcsa, Bin Li, 2015, Bioorganic & Medicinal Chemistry Letters.

Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.

A. Mutlib, C. Bigge, J. Edmunds, 2008, Chemical research in toxicology.

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

N. Powell, Amy M. Delaney, Michael D. Kaufman, 2013, Bioorganic & medicinal chemistry letters.

Cheminformatic tools for medicinal chemists.

P. Hajduk, S. Muchmore, K. Stewart, 2010, Journal of medicinal chemistry.

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

N. Powell, C. Catana, Min Zhong, 2013, Bioorganic & medicinal chemistry letters.