D. Aharony

发表

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Gianni Chessari, Christopher W Murray, Miles Congreve, 2007, Journal of medicinal chemistry.

The Mechanism of γ-Secretase

B. Greenberg, Xiaodong Liu, D. Aharony, 2003, Journal of Biological Chemistry.

Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis

Clay W Scott, R. Bhat, C. Scott, 2003, Journal of Pharmacology and Experimental Therapeutics.

Isolation and characterization of neurokinin A receptor cDNAs from guinea-pig lung and rabbit pulmonary artery.

S. Powell, D. Aharony, A. Graham, 1994, Journal of receptor and signal transduction research.

Modulation of affinity and density of LTB4 receptors on guinea pig lung membranes by divalent cations and guanine nucleotides.

D. Aharony, R. C. Falcone, 1991, European journal of pharmacology.

Specific binding of 3H-ICI 198,615, a potent LTD4 antagonist, to guinea pig cardiac ventricular membranes.

D. Aharony, R. Orzechowski, R. C. Falcone, 1990, Prostaglandins.

Biochemical and Pharmacological Characterization of the Binding of the Selective Peptide‐Leukotriene Antagonist, 3H‐ICI 198,615, to Leukotriene D4 Receptors in Guinea‐Pig Lung Membranes

R. Krell, D. Aharony, R. Giles, 1988, Annals of the New York Academy of Sciences.

Inhibition by REV-5901 of leukotriene release from guinea-pig and human lung tissue in vitro.

R. Krell, D. Aharony, E. J. Kusner, 1989, Biochemical pharmacology.

Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents.

D. Aharony, R. C. Falcone, 1990, The Journal of pharmacology and experimental therapeutics.

In vitro metabolism of [3H]-peptide leukotrienes in human and ferret lung: a comparison with the guinea pig.

R. Krell, D. Aharony, P. Dobson, 1985, Biochemical and biophysical research communications.

The preclinical pharmacology of ICI 204,219. A peptide leukotriene antagonist.

R. Keith, V. Matassa, R. Krell, 1990, The American review of respiratory disease.

Expression of rat NK-2 (neurokinin A) receptor in E. coli.

R. Grisshammer, D. Aharony, J. Little, 1994, Receptors & channels.

Leukotriene D4 increases both the force of contraction and polyphosphoinositide formation in guinea-pig papillary muscle.

P. Siegl, D. Aharony, A. Scott, 1991, European journal of pharmacology.

Evidence for leukotriene D4 receptors in guinea pig left atria.

D. Aharony, R. Orzechowski, R. C. Falcone, 1991, The Journal of pharmacology and experimental therapeutics.

Kinetic and pharmacologic analysis of [3H]leukotriene E4 binding to receptors on guinea pig lung membranes: evidence for selective binding to a subset of leukotriene D4 receptors.

D. Aharony, C. A. Catanese, R. C. Falcone, 1989, The Journal of pharmacology and experimental therapeutics.

Pharmacological and biochemical evidence for metabolism of peptide leukotrienes by guinea-pig airway smooth muscle in vitro.

R. Krell, D. Snyder, D. Aharony, 1984, The Journal of pharmacology and experimental therapeutics.

Discovery of novel, orally active dual NK1/NK2 antagonists.

W. Rumsey, P. Bernstein, J. Albert, 2001, Bioorganic & medicinal chemistry letters.

4-Alkylpiperidines related to SR-48968: potent antagonists of the neurokinin-2 (NK2) receptor.

D. Aharony, R. Mauger, R. Jacobs, 1998, Bioorganic & medicinal chemistry letters.

Substituted 2,4-diaminoquinazolines and 2,4-diamino-8-alkylpurines as antagonists of the neurokinin-2 (NK2) receptor

D. Aharony, R. Mauger, R. Jacobs, 1995 .

Pharmacology of leukotriene receptor antagonists.

D. Aharony, 1998, American journal of respiratory and critical care medicine.

Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase.

R. Stein, D. Aharony, 1986, The Journal of biological chemistry.

Inhibition of human platelet lipoxygenase by cyanide

D. Aharony, J. Smith, M. Silver, 1982, Experientia.

Effects of arachidonic acid hydroperoxides on vascular and non-vascular smooth muscle.

E. F. Smith, A. M. Lefer, A. Lefer, 1981, Prostaglandins and medicine.

Inhibition of platelet lipoxygenase by toluene-3,4-dithiol and other ferric iron chelators.

D. Aharony, J. Smith, M. Silver, 1981, Prostaglandins and medicine.

Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents.

A. M. Lefer, A. Lefer, D. Aharony, 1979, Prostaglandins.

Biosynthesis of thromboxane B2 and 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets. Evidence for a common enzymatic pathway.

D. Aharony, A. Raz, R. Kenig-Wakshal, 1978, European journal of biochemistry.

Pharmacology of Peptide Leukotriene Receptor Antagonists

R. Krell, D. Aharony, DAVID AHARONY, 1991, Annals of the New York Academy of Sciences.

Biochemical and pharmacological characterization of ICI 198,615: a peptide leukotriene receptor antagonist.

R. Krell, D. Aharony, E. J. Kusner, 1989, European journal of pharmacology.

Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.

W. Rumsey, B. Undem, P. Bernstein, 2001, The Journal of pharmacology and experimental therapeutics.

Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615.

D. Aharony, D. Redkar-Brown, 1989, European journal of pharmacology.

Pharmacologic characterization of the contractile activity of peptide leukotrienes in guinea-pig pulmonary artery.

R. Krell, D. Snyder, D. Aharony, 1990, Prostaglandins.

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.

W. Rumsey, J. R. Damewood, D. Banville, 2000, Bioorganic & medicinal chemistry letters.

Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615.

R. Krell, D. Aharony, R. C. Falcone, 1987, Journal of Pharmacology and Experimental Therapeutics.

Peptide leukotriene receptors and antagonists.

R. Krell, D. Aharony, E. J. Kusner, 1990, Advances in prostaglandin, thromboxane, and leukotriene research.

Pharmacologic characterization of the novel ligand [4,5-3H-Leu9]Neurokinin-A binding to NK-2 receptors on hamster urinary bladder membranes

D. Aharony, G. E. Conner, D. P. Woodhouse, 1992, Neuropeptides.

Determination of SRS-A release from guinea-pig lungs by a radioimmunoassay.

R. Krell, P. Bernstein, D. Aharony, 1983, Biochemical and biophysical research communications.

A radiochemical assay for detection of leukotriene B4 production from isolated cells.

R. Krell, D. Aharony, P. Dobson, 1984, Journal of pharmacological methods.

Assessment of leukotriene D4 receptor antagonists.

D. Aharony, 1990, Methods in enzymology.

Carbocyclic thromboxane A2: aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog.

A. M. Lefer, E. Smith, R. Magolda, 1981, Prostaglandins.

Measurement of Leukotriene Release from Rat Peritoneal Cells with a Specific Radioimmunoassay

R. Krell, P. Bernstein, D. Aharony, 1984 .

Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation.

E. F. Smith, A. M. Lefer, R. Magolda, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid.

D. Aharony, J. Smith, M. Silver, 1982, Biochimica et biophysica acta.

Discriminative effect of gamma-glutamyl transpeptidase inhibitors on metabolism of leukotriene C4 in peritoneal cells.

D. Aharony, P. Dobson, 1984, Life sciences.

Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

J. Evenden, W. Rumsey, B. Masek, 2004 .

Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.

W. Rumsey, P. Bernstein, J. Albert, 2002, Journal of medicinal chemistry.

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Jian Yu, P. Schroeder, Christopher A. Hurley, 2013, ACS medicinal chemistry letters.

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Gianni Chessari, Mark Sylvester, Rutger H A Folmer, 2007, Journal of medicinal chemistry.

Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles.

R. Keith, V. Matassa, T. Maduskuie, 1990, Journal of medicinal chemistry.

Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2.

A. M. Lefer, E. Smith, R. Magolda, 1980, Proceedings of the National Academy of Sciences of the United States of America.

3 – Platelet Arachidonate Lipoxygenase

D. Aharony, J. Smith, M. Silver, 1984 .

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists.

W. Rumsey, B. Masek, P. Bernstein, 2004, Bioorganic & medicinal chemistry.

Development of a sensitive method for measurement of leukotriene production by isolated cells.

R. Krell, D. Aharony, P. Dobson, 1983, Research communications in chemical pathology and pharmacology.

Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity.

A. Graham, S. Meeker, B. Undem, 1995, The Journal of pharmacology and experimental therapeutics.

Kinetic studies on the inactivation of 5-lipoxygenase by 5(S)-hydroperoxyeicosatetraenoic acid.

R. Stein, D. Aharony, S. Hubbs, 1987, Prostaglandins.

Testosterone Potentiation of Ionophore and ADP Induced Platelet Aggregation : Relationship to Arachidonic Acid Metabolism

D. Aharony, A. Raz, R. Pilo, 1981, Thrombosis and Haemostasis.

Identification of Multiple Glutathione Conjugates of 8-Amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine

Dean G. Brown, D. Aharony, D. Burdette, 2010, Drug Metabolism and Disposition.

Identification of Multiple Glutathione Conjugates of Nomifensine in Liver Microsomes and Hepatocyte Preparations : Evidence of the Bioactivation of Nomifensine

Dean G. Brown, D. Aharony, D. Burdette, 2009 .

Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system.

R. Gordon, R. Hockney, S. Powell, 1993, Molecular pharmacology.

Isolation and pharmacological characterization of a hamster urinary bladder neurokinin A receptor cDNA.

S. Powell, D. Aharony, A. Graham, 1994, Molecular Pharmacology.

Characterization of bradykinin receptors in guinea pig gall bladder.

R. Krell, D. Aharony, S. Hubbs, 1993, The Journal of pharmacology and experimental therapeutics.

Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a Potent, Orally Ac

P. Bernstein, D. Aharony, R. Jacobs, 1994 .

The Mechanism of -Secretase MULTIPLE INHIBITOR BINDING SITES FOR TRANSITION STATE ANALOGS AND SMALL MOLECULE INHIBITORS*

B. Greenberg, D. Aharony, G. Tian, 2003 .

Binding of the novel ligand [4,5-3H-Leu10]substance P to high-affinity NK-1 receptors on guinea pig lung membranes: modulation by GTP analogs and sulfhydryl modifying agents.

D. Aharony, D. P. Woodhouse, C. Catanese, 1991, The Journal of pharmacology and experimental therapeutics.

[¹²⁵I]YP20: a novel radioligand specific for the extracellular domain of the CRF₁ receptor.

R. Bostwick, C. Elmore, Clay Scott, 2010, European journal of pharmacology.