B. Wirz

发表

Chemoenzymatic preparation of non-racemic N-Boc-piperidine-3,5-dicarboxylic acid 3-methyl esters and their 5-hydroxymethyl derivatives

H. Iding, B. Wirz, R. Sarmiento, 2003 .

Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance

U. Bornscheuer, H. Iding, I. V. Pavlidis, 2017, Chembiochem : a European journal of chemical biology.

Development of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety

B. Wirz, S. Hanlon, Jean-Michel Adam, 2011 .

Extended Catalytic Scope of a Well‐Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase

Michael Müller, S. Lüdeke, D. Wetzl, 2017, Chembiochem : a European journal of chemical biology.

Biocatalysis in the Fine Chemical and Pharmaceutical Industries

Joseph P. Adams, Peter W. Sutton, Roger M. Howard, 2012 .

Industrial Hydrolases and Related Enzymes

Roger M. Howard, Gary Francis GlaxoSmithKline Breen, Rebecca E. Meadows, 2012 .

Inflammatory responses predict long-term mortality risk in community-acquired pneumonia

M. Christ-Crain, W. Zimmerli, P. Schuetz, 2010, European Respiratory Journal.

Asymmetric enzymatic hydrolysis of prochiral 2-O-allylglycerol ester derivatives

B. Wirz, J. Foricher, R. Schmid, 1992 .

Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.

D. Banner, W. Haap, A. Kuglstatter, 2013, Journal of medicinal chemistry.

A Continuous Lipase-Catalyzed Acylation Process for the Large-Scale Production of Vitamin A Precursors

B. Wirz, S. Bischof, B. Orsat, 1999, CHIMIA.

Novel versatile approach to an enantiopure 19-nor, des-C,D vitamin D3 derivative

H. Hilpert, B. Wirz, 2001 .

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib.

F. Gosselin, H. Iding, S. Bachmann, 2017, Organic letters.

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine.

U. Bornscheuer, H. Iding, I. V. Pavlidis, 2016, Organic & biomolecular chemistry.

The synthetic development of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu®): A challenge for synthesis & process research

P. Harrington, H. Iding, B. Wirz, 2004 .

Large scale preparation of chiral building blocks for the P3 site of renin inhibitors.

W. Wostl, H. Stadler, B. Wirz, 1994, Bioorganic & medicinal chemistry.

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale.

Anton Glieder, Sandra Abad, Beat Wirz, 2012, Chemical communications.

Separation of pyrrolidine allylation products by diastereoselective enzymatic ester hydrolysis

H. Iding, M. Rogers-Evans, V. Aggarwal, 2005 .

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein‐Sequence Space

Michael Müller, M. Ebeling, D. Wetzl, 2015, Chembiochem : a European journal of chemical biology.

Enzymatic preparation of chiral 3-(hydroxymethyl)piperidine derivatives

W. Walther, B. Wirz, 1992 .

Enzymatic Preparation of (R)-3-Hydroxy-2-Methylpropyl Butyrate by Asymmetric Hydrolysis

W. Walther, B. Wirz, R. Schmid, 1990 .

Asymmetric Reductive Amination of Ketones Catalyzed by Imine Reductases

Alfred Ross, Hans Iding, Dennis Wetzl, 2016 .

New, efficient synthesis of oseltamivir phosphate (Tamiflu) via enzymatic desymmetrization of a meso-1,3-cyclohexanedicarboxylic acid diester.

H. Iding, B. Wirz, P. Spurr, 2008, The Journal of organic chemistry.

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines.

Hans Iding, Uwe T Bornscheuer, Paul Spurr, 2016, Nature chemistry.

Asymmetric oxidoreductions catalyzed by alcohol dehydrogenase in organic solvents

A. Klibanov, J. Grunwald, B. Wirz, 1986 .

Facile chemoenzymic preparation of enantiomerically pure 2-methylglycerol derivatives as versatile trifunctional C4-synthons

B. Wirz, R. Barner, Josef Huebscher, 1993 .

Asymmetric Oxidoreductions Catalyzed by Alcohol Dehydrogenase in Organic Solvents.

A. Klibanov, J. Grunwald, B. Wirz, 1987 .

Chemo-enzymatic preparation of chiral 3-aminopyrrolidine derivatives

H. Iding, M. Rogers-Evans, B. Wirz, 2004 .

The Synthetic Development of the Antiinfluenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu): A Challenge for Synthesis & Process Research

P. Harrington, H. Iding, B. Wirz, 2005 .

Enantioselective synthesis of (1R,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-exo-carboxylic acid

Christopher Pfleger, B. Wirz, P. Spurr, 2010 .

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

Martina Geier, Beat Wirz, Matthias Kittelmann, 2015, Microbial Cell Factories.

Enzymatic preparation of homochiral 2-isobutyl succinic acid derivatives

B. Wirz, M. Soukup, 1997 .

Human flavin monooxygenase 2: Heterologous expression in E. coli and API modification

A. Glieder, M. Geier, S. Lütz, 2014 .

Multiselective enzymatic reactions for the synthesis of protected homochiral cis- and trans-1,3,5-cyclohexanetriols

H. Iding, H. Hilpert, B. Wirz, 2000 .

Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis.

Beat Wirz, Matthias Kittelmann, Margit Winkler, 2016, Journal of biotechnology.