M. Namchuk

发表

An open toolkit for tracking open science partnership implementation and impact

Brian A. Nosek, Jennifer C Molloy, Sébastien Paquet, 2019, Gates open research.

An open toolkit for tracking open science partnership implementation and impact [version 1; peer review: awaiting peer review].

Brian A. Nosek, Jennifer C Molloy, Sébastien Paquet, 2018 .

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

Yurii S. Moroz, Christian C. Gruber, R. Davey, 2021, iScience.

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

Yurii S. Moroz, Christian C. Gruber, R. Davey, 2020, ChemRxiv : the preprint server for chemistry.

In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder

D. Deaver, J. Bidlack, D. Arnelle, 2018, The Journal of Pharmacology and Experimental Therapeutics.

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Act

P. Charifson, C. Decker, U. Germann, 2007, Journal of Pharmacology and Experimental Therapeutics.

Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus

S. Baekkeskov, C. Turck, H. Erlich, 1994, The Journal of experimental medicine.

Delivery of long-acting injectable antivirals: best approaches and recent advances

E. Merisko-Liversidge, J. Remenar, Magali B. Hickey, 2015, Current opinion in infectious diseases.

VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia.

Jiehua Zhou, G. Henkel, Yung-mae M. Yao, 2012, Journal of medicinal chemistry.

Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia.

V. Galullo, G. Henkel, J. Ma, 2011, Journal of medicinal chemistry.

Substrate-induced inactivation of a crippled beta-glucosidase mutant: identification of the labeled amino acid and mutagenic analysis of its role.

S. Withers, R. Aebersold, J. Gebler, 1995, Biochemistry.

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

S. Harrison, G. Frey, M. Namchuk, 2021, bioRxiv.

c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo

Yow-Ming C Wang, F. Salituro, P. Tsichlis, 2005, Circulation research.

Syntheses of 2-deoxy-2-fluoro mono- and oligo-saccharide glycosides from glycals and evaluation as glycosidase inhibitors.

S. Withers, J. McCarter, D. Tull, 1993, Carbohydrate research.

Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization

A. Barabasi, S. Elledge, M. Zitnik, 2022, iScience.

Early Returns on Small Molecule Therapeutics for SARS-CoV-2.

M. Namchuk, 2021, ACS infectious diseases.

Phosphorylation of Serine Residues 3, 6, 10, and 13 Distinguishes Membrane Anchored from Soluble Glutamic Acid Decarboxylase 65 and Is Restricted to Glutamic Acid Decarboxylase 65α*

S. Baekkeskov, C. Turck, J. Kanaani, 1997, The Journal of Biological Chemistry.

Design, synthesis, and characterization of a protein sequencing reagent yielding amino acid derivatives with enhanced detectability by mass spectrometry

R. Aebersold, B. Shushan, E. Bures, 1992, Protein science : a publication of the Protein Society.

A review of clinical efficacy data supporting emergency use authorization for COVID‐19 therapeutics and lessons for future pandemics

M. Namchuk, Kira Nagoshi, M-Y Lu, 2022, Clinical and translational science.

Mechanism of Agrobacterium beta-glucosidase: kinetic analysis of the role of noncovalent enzyme/substrate interactions.

S. Withers, M. Namchuk, 1995, Biochemistry.

The Role of Sugar Substituents in Glycoside Hydrolysis

S. Withers, J. McCarter, A. Becalski, 2000 .

The Role of Sugar Substituents in Glycoside Hydrolysis.

S. Withers, J. McCarter, A. Becalski, 2000 .

Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease

Keisuke Kuida, Mark Namchuk, Keykavous Parang, 2004, Circulation.

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)

Paul Shapiro, Alex M Aronov, Mark Namchuk, 2017, Molecular Cancer Therapeutics.

Advancing New Chemical Modalities into Clinical Studies.

M. Blanco, M. Namchuk, K. Gardinier, 2022, ACS medicinal chemistry letters.

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.

F. Salituro, Hui-Sheng Huang, Edmund M. Harrington, 2015, Journal of medicinal chemistry.

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

Xiaoling Xie, Jingrong Cao, Alex M Aronov, 2009, Journal of medicinal chemistry.

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo

A. Barabasi, S. Elledge, M. Zitnik, 2022, bioRxiv.

Abstract 4693: The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance

J. Roix, M. Garnett, C. Benes, 2015 .

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.

Xiaoling Xie, Jingrong Cao, Alex M Aronov, 2007, Journal of medicinal chemistry.

A guide to drug discovery: Designing screens: how to make your hits a hit

W. Patrick Walters, Mark Namchuk, W. P. Walters, 2003, Nature Reviews Drug Discovery.

Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates

M. Todtenkopf, C. Sánchez, D. Deaver, 2019, Journal of psychopharmacology.

Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers

F. Toledo, J. Newcomer, B. Silverman, 2021, Neuropsychopharmacology.

In vitro and in vivo isotope effects with hepatitis C protease inhibitors: enhanced plasma exposure of deuterated telaprevir versus telaprevir in rats.

F. Maltais, Hui-Sheng Huang, S. Pazhanisamy, 2009, Journal of medicinal chemistry.

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors.

L. Chan, S. Das, L. L'Heureux, 2014, ACS medicinal chemistry letters.

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo

A. Barabasi, M. Zitnik, J. Loscalzo, 2021, bioRxiv.

Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates

M. Todtenkopf, C. Sánchez, D. Deaver, 2019, European Neuropsychopharmacology.

(S)-1-((S)-2- -3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1beta

P. Charifson, U. Germann, K. Kuida, 2007 .

In vivo Characterization of the Opioid Receptor–Binding Profiles of Samidorphan and Naltrexone in Rats: Comparisons at Clinically Relevant Concentrations

J. Cunningham, M. Namchuk, Lei Sun, 2021, Biological Psychiatry.

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

G. Bemis, F. Maltais, J. Janetka, 2009, Journal of medicinal chemistry.

Finding the molecules to fuel chemogenomics

Mark Namchuk, M. Namchuk, 2002 .

Fluorinated Sugars as Probes of Glycosidase Mechanisms

S. Withers, J. McCarter, C. Braun, 1996 .