Jérôme Toum

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Christophe Simon, P. Bamborough, R. Prinjha, 2014, Journal of medicinal chemistry.

Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

P. Bamborough, R. Prinjha, R. Grimley, 2011, Journal of medicinal chemistry.

Discovery of Pyridones As Oral AMPK Direct Activators.

E. Nicodème, L. Trottet, O. Mirguet, 2013, ACS medicinal chemistry letters.

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

E. Nicodème, J. Kirilovsky, L. Trottet, 2012, Bioorganic & medicinal chemistry letters.

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.

M. Lambert, H. Xu, D. Grillot, 2007, Journal of medicinal chemistry.

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

P. Bamborough, R. Prinjha, C. Chung, 2013, Journal of medicinal chemistry.