P. Willis

发表

Open source drug discovery – A limited tutorial

Murray N. Robertson, Alice E. Williamson, Paul M. Ylioja, 2013, Parasitology.

8-Trisubstituted Quinolines with Antimalarial Activity

L. Dias, P. Willis, P. D. G. Martinez, 2018 .

2,3,8-Trisubstituted Quinolines with Antimalarial Activity.

L. Dias, P. Willis, P. D. G. Martinez, 2018, Anais da Academia Brasileira de Ciencias.

Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

Robin B. Gasser, Abdul Jabbar, Sarah Preston, 2016, International journal for parasitology. Drugs and drug resistance.

Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.

A. Bailey, David Cox, P. Leff, 1999, Journal of medicinal chemistry.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Erika L. Flannery, Victoria C. Corey, Yingyao Zhou, 2018, Science.

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

W. V. Van Voorhis, C. Huston, J. Burrows, 2015, PLoS neglected tropical diseases.

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

P. Leeson, B. Springthorpe, P. Barton, 2007, Bioorganic & medicinal chemistry letters.

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold.

David M. Wilson, G. Drewes, P. Bamborough, 2017, Journal of medicinal chemistry.

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

S. Harper, S. Altamura, N. Gennari, 2016, ACS medicinal chemistry letters.

The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors.

P. Raubo, P. Willis, R. Evans, 2020, Bioorganic & medicinal chemistry letters.

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.

R. Austin, R. Jewell, M. Christie, 2007, Bioorganic & medicinal chemistry letters.

New non-peptide angiotensin II receptor antagonists. 1: structure - activity relationships of a series of a series of 2(1H)-pyridinones.

A. Tinker, H. Beaton, S. Cooper, 1994 .

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

David W. Gray, E. Winzeler, S. Meister, 2016, Journal of medicinal chemistry.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

E. Winzeler, S. Meister, S. Norval, 2016, Journal of medicinal chemistry.

A tandem radical cyclisation approach to the hexahydrobenzofuran skeleton for avermectin synthesis

P. Parsons, S. Eyley, P. Willis, 1988 .

A synthesis of the hexahydrobenzofuran portion of the avermectins I. Model studies

P. Parsons, S. Eyley, P. Willis, 1992 .

Tin and Palladium Mediated Tandem Cyclisaton for the Construction of Intermediates for Natural Product Synthesis

Marijan Štefinović, P. Parsons, P. Willis, 1992 .

Photochemistry of tricarbonyl (η5-cyclopentadienyl)(trifluoroacetyl)-molybdenum in a variety of frozen gas matrices at ca. 12 K: infrared spectroscopic evidence for carbon monoxide ejection and difluorocarbene formation by α-F elimination

P. Willis, A. Rest, Andrew K. Campen, 1990 .

Development of two processes for the synthesis of bridged azabicyclic systems: intermolecular radical addition-homoallylic rearrangements leading to 2-azanorborn-5-enes and neophyl-type radical rearrangements to 2-azabenzonorbornanes.

P. Willis, D. M. Hodgson, M. Bebbington, 2003, Organic & biomolecular chemistry.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.

S. Charman, E. Ryan, L. Dias, 2017, European journal of medicinal chemistry.

The Pandemic Response Box—Accelerating Drug Discovery Efforts after Disease Outbreaks

Anirban Dutta, G. Bilbe, Ben Perry, 2022, ACS infectious diseases.

Susceptibility Testing of Medically Important Parasites

D. Leroy, D. Pillai, W. V. Van Voorhis, 2017, Clinical Microbiology Reviews.

2-azabenzonorbornanes from 7-azabenzonorbornanols by a nitrogen-directed neophyl-type radical rearrangement.

P. Willis, D. M. Hodgson, M. Bebbington, 2002, Organic letters.

Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analog: solvent effect on the stereochemistry of the crucial C-15/C-18' bond

M. Ladlow, P. Willis, P. Magnus, 1992 .

A broad analysis of resistance development in the malaria parasite

Gregory M. Goldgof, Victoria C. Corey, Yingyao Zhou, 2016, Nature Communications.

An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.

Benedict Irwin, Benedict W J Irwin, Gareth Conduit, 2020, Journal of medicinal chemistry.

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

Jeremy N. Burrows, Timothy N. C. Wells, Paul Willis, 2013, PloS one.

Antimalarial drug discovery – the path towards eradication

D. Leroy, J. Burrows, T. Wells, 2013, Parasitology.

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

D. Kyle, J. Burrows, Roman Manetsch, 2016, Journal of medicinal chemistry.

Small molecule anti-malarial patents: a review (January 2010 – June 2011)

S. Macdonald, P. Willis, Katarina L Svennas, 2012, Expert opinion on therapeutic patents.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Victoria C. Corey, Yingyao Zhou, E. Winzeler, 2017, Science.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Julie Clark, George Papadatos, Jeremy N. Burrows, 2016, ACS central science.

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

P. Hewitt, D. Picard, S. Charman, 2017, ACS medicinal chemistry letters.

Open data in drug discovery and development: lessons from malaria

Jeremy N. Burrows, Timothy N. C. Wells, Paul Willis, 2016, Nature Reviews Drug Discovery.

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

George Papadatos, Paul Willis, Jeremy N Burrows, 2014, Malaria Journal.

Actives from MMV Open Access Boxes? A suggested way forward

J. Burrows, P. Webborn, P. Willis, 2021, PLoS pathogens.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

D. Kyle, J. Burrows, Raghupathi Neelarapu, 2017, Journal of medicinal chemistry.

Susceptibility Testing of Medically Important Parasites

D. Leroy, D. Pillai, W. V. Van Voorhis, 2017, Clinical Microbiology Reviews.

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

S. Harper, S. Altamura, N. Gennari, 2016, ACS medicinal chemistry letters.