J. Rocher

发表

New technologies enabling the industrialization of allosteric modulator discovery.

Benjamin G. Perry, R. Lütjens, Dominik W. Schelshorn, 2013, Drug discovery today. Technologies.

Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2012, Journal of medicinal chemistry.

mGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders

S. Poli, Sylvain Celanire, J. Rocher, 2012 .

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011 .

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.

G. Macdonald, H. Lavreysen, P. Cluzeau, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

María Lourdes Linares, G. Macdonald, G. Tresadern, 2010, ACS chemical neuroscience.

Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders

R. Lütjens, J. Rocher, 2017, Current opinion in pharmacology.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sarah L. Huszar, J. Uslaner, T. Tucker, 2014, Neuropharmacology.

Boron Nitride Interphase in Ceramic‐Matrix Composites

R. Naslain, O. Dugne, A. Guette, 1991 .

Allosteric Modulation : a Novel Approach to Drug Discovery

J. Rocher, E. Poul, M. Epping-Jordan, 2022 .

Interface characterization by TEM, AES and SIMS in tough SiC (ex-PCS) fibre-SiC (CVI) matrix composites with a BN interphase

R. Naslain, O. Dugne, A. Guette, 1993 .

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.

D. Charvin, S. Gagliardi, E. Le Poul, 2013, Bioorganic & medicinal chemistry letters.

Wetting improvement of carbon or silicon carbide by aluminium alloys based on a K2ZrF6 surface treatment: application to composite material casting

R. Naslain, J. Rocher, J. Quenisset, 1989 .

A new casting process for carbon (or SiC-based) fibre-aluminium matrix low-cost composite materials

R. Naslain, J. Rocher, J. Quenisset, 1985 .

The K2ZrF6 wetting process: Effect of surface chemistry on the ability of a SiC-Fiber preform to be impregnated by aluminum

S. Schamm, R. Naslain, J. Rocher, 1991 .

G-protein activation by a metabotropic glutamate receptor

M. J. Robertson, J. M. Mathiesen, G. Skiniotis, 2021, Nature.

mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.

V. Mutel, B. Ludwig, E. Le Poul, 2011, Current topics in medicinal chemistry.

Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson’s Disease

V. Mutel, M. Kalinichev, C. Boléa, 2023, Cells.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

María Lourdes Linares, J. M. Alonso, G. Macdonald, 2014, Journal of medicinal chemistry.

Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders

M. Jacobson, T. Williams, M. Kalinichev, 2014 .

Strategies in the Search for New Lead Compounds or Original Working Hypotheses

Bruno O. Villoutreix, Camille Georges Wermuth, Anne Olivier, 2015 .

Chapter 12 – Application Strategies for the Primary Structure–Activity Relationship Exploration

Bruno O. Villoutreix, Camille Georges Wermuth, Serge Grisoni, 2015 .

Syntheses, activity and modeling studies of 3- and 4-(sulfo- and sulfonamidoalkyl)pyridine and piperidine-2-carboxylic acid derivatives as analogs of NMDA receptor antagonists.

P. Maldivi, J. Rocher, A. El Hadri, 1995, Bioorganic & medicinal chemistry.