H. Mönkkönen

发表

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase.

V. Castronovo, A. Bellahcène, P. Clézardin, 2011, Bone.

Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.

Mark B. Jones, I. Holen, R. Coleman, 2008, Journal of the National Cancer Institute.

Differential Effect of Doxorubicin and Zoledronic Acid on Intraosseous versus Extraosseous Breast Tumor Growth In vivo

S. Cross, I. Holen, R. Coleman, 2008, Clinical Cancer Research.

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

P. Musiani, I. Holen, M. Boccadoro, 2009, Journal of cellular and molecular medicine.

Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry.

J. Mönkkönen, S. Auriola, J. Räikkönen, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells.

J. Mönkkönen, S. Auriola, J. Räikkönen, 2010, Biochemical pharmacology.

Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP

J. Mönkkönen, H. Mönkkönen, A. Roelofs, 2009, British journal of haematology.

Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients

K. Boudjema, J. Mönkkönen, V. Lavoué, 2010, Cancer Immunology, Immunotherapy.

Zoledronic acid-induced IPP/ApppI production in vivo.

I. Holen, J. Mönkkönen, S. Auriola, 2007, Life sciences.

In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger Vγ9Vδ2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement

J. Mönkkönen, P. Clézardin, E. Bonnelye, 2012, Clinical Cancer Research.

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.

J. Mönkkönen, S. Auriola, J. Räikkönen, 2011, Biochemical and biophysical research communications.

Activation of γδ T cells by bisphosphonates.

J. Mönkkönen, M. Rogers, H. Mönkkönen, 2010, Advances in experimental medicine and biology.

In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts.

Hannu-Ville Leskelä, P. Lehenkari, V. Parikka, 2005, Basic & clinical pharmacology & toxicology.

Bisphosphonates in cancer therapy.

P. Clézardin, V. Stresing, H. Mönkkönen, 2007, Cancer letters.

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.

E. Adams, D. Olive, M. Bonneville, 2012, Blood.

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates

I. Hassinen, P. Lehenkari, J. Mönkkönen, 2006, British journal of pharmacology.

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.

J. Mönkkönen, S. Auriola, J. Frith, 2001, Arthritis and rheumatism.

Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells.

J. Määttä, S. Arkko, J. Mönkkönen, 2015, Cancer letters.

Zoledronic acid induces formation of a pro‐apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF‐7 cells in vitro

J. Mönkkönen, S. Auriola, J. Räikkönen, 2009, British journal of pharmacology.

High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.

J. Mönkkönen, P. Clézardin, E. Bonnelye, 2011, Cancer research.

Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth

I. Holen, J. Mönkkönen, S. Auriola, 2008, Anti-cancer drugs.

Activation of gammadelta T Cells by Bisphosphonates

J. Mönkkönen, M. Rogers, H. Mönkkönen, 2010 .

The Cellular Uptake and Metabolism of Clodronate in RAW 264 Macrophages

J. Mönkkönen, S. Auriola, M. Rogers, 2001, Pharmaceutical Research.

Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry.

J. Mönkkönen, S. Auriola, J. Frith, 2000, Journal of chromatography. B, Biomedical sciences and applications.