E. V. van Beek

发表

Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.

Ting-Kai Chang, Kilannin Krysiak, Mitsuo Ochi, 2009, Journal of the American Chemical Society.

Ceramic hydroxyapatite implants for the release of bisphosphonate.

C. Löwik, S. Papapoulos, A. van den Hooff, 1994, Bone and mineral.

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

R. Dacosta, T. Snoeks, C. Löwik, 2016, Molecular Imaging and Biology.

Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice

A. Wetterwald, M. Cecchini, C. Löwik, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

E. Pieterman, C. Löwik, S. Papapoulos, 1999, Biochemical and biophysical research communications.

Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA.

J. van der Zee, T. Dubbelman, J. van Steveninck, 1987, The Biochemical journal.

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

R. Dacosta, T. Snoeks, C. Löwik, 2016, Front. Oncol..

Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

M. Hoehn, V. Ntziachristos, D. Razansky, 2015, Oncotarget.

The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen‐Containing Bisphosphonates

C. Löwik, G. van der Pluijm, S. Papapoulos, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of experimental conditions on the release of 45calcium from prelabeled fetal mouse long bones.

C. Löwik, S. Papapoulos, E. V. van Beek, 1995, Bone.

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors.

C. Löwik, S. Papapoulos, E. V. van Beek, 2002, Bone.

Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor.

M. Karperien, C. Löwik, S. Papapoulos, 2006, Bone.

Degradable Bisphosphonate‐Alkaline Phosphatase‐Complexed Hydroxyapatite Implants In Vitro

C. Klein, C. Klein, A. van den Hooff, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates.

C. Löwik, S. Papapoulos, F. Ebetino, 2003, Bone.

Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation.

V. V. van Hinsbergh, C. Löwik, G. van der Pluijm, 2007, European journal of cancer.

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

E. Pieterman, C. Löwik, S. Papapoulos, 1999, Biochemical and biophysical research communications.

Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group

C. Löwik, I. Que, S. Papapoulos, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships.

C. Löwik, F. H. Ebetino, S. Papapoulos, 1998, Bone.

Net-shaped hydroxyapatite implants for release of agents modulating periodontal-like tissues.

R. Martinetti, A. Ravaglioli, C. Klein, 1997, Journal of periodontal research.

Optical imaging of treatment-related tumor cell death using a heat shock protein-90 alkylator.

P. Hogg, C. Löwik, I. Que, 2013, Molecular pharmaceutics.

Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator

P. Hogg, C. Löwik, E. Kaijzel, 2013, Cell Death and Disease.

Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro.

H. Vloedgraven, G. van der Pluijm, G. Pluijm, 1996, The Journal of clinical investigation.

Novel Late Response Genes of PTHrP in Chondrocytes

J. Wit, M. Karperien, C. Löwik, 2006, Hormone Research in Paediatrics.

Structural requirements for bisphosphonate actions in vitro

S. Papapoulos, E. V. van Beek, M van de Ruit, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Leukemia inhibitory factor inhibits osteoclastic resorption, growth, mineralization, and alkaline phosphatase activity in fetal mouse metacarpal bones in culture

P. Nijweide, C. Löwik, S. Papapoulos, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.

V. V. van Hinsbergh, T. Snoeks, C. Löwik, 2010, Biochemical and biophysical research communications.

Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model

Ivo Que, Eric L. Kaijzel, Thomas J. A. Snoeks, 2012, PloS one.

Multicolor fluorescence imaging of traumatic brain injury in a cryolesion mouse model.

M. Hoehn, Bryan A. Smith, C. Löwik, 2012, ACS chemical neuroscience.

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

E. Oldfield, Yongcheng Song, D. González-Pacanowska, 2005, Journal of medicinal chemistry.

Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice.

C. Löwik, S. Papapoulos, E. V. van Beek, 1997, Bone.

Effect of PLGA NP size on efficiency to target traumatic brain injury.

T. Snoeks, C. Löwik, E. Kaijzel, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Bioluminescence imaging of bone metastasis in rodents.

T. Snoeks, C. Löwik, E. Kaijzel, 2012, Methods in molecular biology.

Multicolor fluorescence imaging of traumatic brain injury in a cryolesion mouse model.

M. Hoehn, C. Löwik, E. Kaijzel, 2012, ACS chemical neuroscience.