U. Shinde

发表

Intramolecular chaperones: polypeptide extensions that modulate protein folding.

M. Inouye, M Inouye, U. Shinde, 2000, Seminars in cell & developmental biology.

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution.

M. Inouye, H. Berman, Y. Li, 1998, Journal of molecular biology.

Cumulative deamidations of the major lens protein γS‐crystallin increase its aggregation during unfolding and oxidation

J. Carver, K. Lampi, T. Wales, 2020, Protein science : a publication of the Protein Society.

Soluble Repulsive Guidance Molecule c/Hemojuvelin Is a Broad Spectrum Bone Morphogenetic Protein (BMP) Antagonist and Inhibits both BMP2- and BMP6-mediated Signaling and Gene Expression*

P. Rotwein, M. Nili, U. Shinde, 2010, The Journal of Biological Chemistry.

Ubiquitin‐associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi‐ubiquitin chain assembly

Li Chen, K. Madura, T. Ortolan, 2001, EMBO reports.

Signaling-Biased and Constitutively Active Dopamine D2 Receptor Variant.

K. Neve, John T. Williams, M. Tijssen, 2021, ACS chemical neuroscience.

The Mechanism by Which a Propeptide-encoded pH Sensor Regulates Spatiotemporal Activation of Furin*

U. Shinde, J. Elferich, G. Thomas, 2013, The Journal of Biological Chemistry.

Export of proteins across membranes: The helix reversion hypothesis

T. N. Guru Row, U. Shinde, Y. Mawal, 1989, Bioscience reports.

Folding pathway mediated by an intramolecular chaperone.

M. Inouye, U. Shinde, S. Chatterjee, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of Fine-tuning pH Sensors in Proprotein Convertases

U. Shinde, J. Elferich, Danielle M. Williamson, 2015, The Journal of Biological Chemistry.

Protein memory through altered folding mediated by intramolecular chaperones

M. Inouye, J. J. Liu, U. Shinde, 1997, Nature.

Erratum: Protein memory through altered folding mediated by intramolecular chaperones

M. Inouye, U. Shinde, J. Liu, 1998, Nature.

Folding pathway mediated by an intramolecular chaperone: characterization of the structural changes in pro-subtilisin E coincident with autoprocessing.

M. Inouye, U. Shinde, 1995, Journal of molecular biology.

Folding mediated by an intramolecular chaperone: autoprocessing pathway of the precursor resolved via a substrate assisted catalysis mechanism.

M. Inouye, U. Shinde, 1995, Journal of molecular biology.

PROPEPTIDES OF PROTEASES EVOLVED SENSORS TO EXPLOIT ORGANELLAR PH

Bala Krishnamoorthy, U. Shinde, J. Elferich, 2012 .

Interactions between Copper-binding Sites Determine the Redox Status and Conformation of the Regulatory N-terminal Domain of ATP7B*

U. Shinde, S. Lutsenko, N. Blackburn, 2009, The Journal of Biological Chemistry.

The structural and functional organization of intramolecular chaperones: the N-terminal propeptides which mediate protein folding.

M. Inouye, U. Shinde, Masayori Inouye, 1994, Journal of biochemistry.

Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult AML patients.

R. Collins, D. Bottomly, S. McWeeney, 2021, Blood.

Mathematical modelling of protein secretion across the endoplasmic reticulum

V. Ghole, U. Shinde, Y. Mawal, 1990 .

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

P. Stork, Maho Takahashi, T. Dillon, 2008, Molecular and Cellular Biology.

An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations.

D. Kabat, James P. Durnin, U. Shinde, 2007, Journal of molecular biology.

Folding Pathway Mediated by an Intramolecular Chaperone PROPEPTIDE RELEASE MODULATES ACTIVATION PRECISION OF PRO-SUBTILISIN*

M. Inouye, H. Takagi, Y. Yabuta, 2001 .

Folding pathway mediated by an intramolecular chaperone: the structural and functional characterization of the aqualysin I propeptide.

H. Matsuzawa, K. Suefuji, Y. Yabuta, 2001, Journal of molecular biology.

Structural organization of human Cu-transporting ATPases: learning from building blocks

U. Shinde, S. Lutsenko, A. Barry, 2009, JBIC Journal of Biological Inorganic Chemistry.

Can the topological distribution of membrane spanning amino acid residues be responsible for the recognition of signal peptides by signal peptide peptidases?

U. Shinde, 1990, Bioscience reports.

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.

Robert Day, Robert T Youker, R. T. Youker, 2009, The Biochemical journal.

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

S. Lowe, B. Druker, A. Agarwal, 2013, Proceedings of the National Academy of Sciences.

Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer

D. Pe’er, M. Ladanyi, M. Kris, 2020, Clinical Cancer Research.

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

M. Davare, Pushkar Shinde, K. Nusser, 2022, bioRxiv.

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

Jimmy D. Dikeakos, J. Dikeakos, G. Thomas, 2012, Molecular biology of the cell.

Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

T. Simmen, G. Thomas, Pushkar Shinde, 2017, Journal of Cell Science.

Monoubiquitination Is Critical for Ovarian Tumor Domain-containing Ubiquitin Aldehyde Binding Protein 1 (Otub1) to Suppress UbcH5 Enzyme and Stabilize p53 Protein*

Yuhuang Li, M. Dai, L. David, 2014, Journal of Biological Chemistry.

MonoubiquitinationIsCriticalforOvarianTumor Domain-containingUbiquitinAldehydeBindingProtein1 (Otub1)toSuppressUbcH5EnzymeandStabilizep53Protein *

Yuhuang Li, M. Dai, L. David, 2014 .

A role for SSRP1 in recombination‐mediated DNA damage response

Hua Lu, A. Kumari, U. Shinde, 2009, Journal of cellular biochemistry.

Folding Pathway Mediated by an Intramolecular Chaperone

M. Inouye, H. Takagi, Y. Yabuta, 2001, The Journal of Biological Chemistry.

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Samuel H. Payne, B. Druker, M. Mori, 2018, Leukemia.

Proteomic analysis and molecular modelling characterize the iron-regulatory protein haemojuvelin/repulsive guidance molecule c.

P. Rotwein, L. David, M. Nili, 2013, The Biochemical journal.

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.

P. Rotwein, U. Shinde, C. Severyn, 2009, The Biochemical journal.

Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity.

V. Hwa, P. Rotwein, R. Rosenfeld, 2013, Molecular endocrinology.

COMMD1 Forms Oligomeric Complexes Targeted to the Endocytic Membranes via Specific Interactions with Phosphatidylinositol 4,5-Bisphosphate*

U. Shinde, S. Lutsenko, Clinton T. Morgan, 2009, Journal of Biological Chemistry.

Defining the Disulfide Bonds of Insulin-like Growth Factor-binding Protein-5 by Tandem Mass Spectrometry with Electron Transfer Dissociation and Collision-induced Dissociation*

P. Rotwein, L. David, M. Nili, 2011, Journal of Biological Chemistry.

Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.

L. David, U. Shinde, J. Elferich, 2015, Analytical chemistry.

Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance

J. Sicklick, M. Heinrich, C. Corless, 2017, Clinical Cancer Research.

Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex

W. Skach, Brian J. Conti, U. Shinde, 2014, Nature Structural &Molecular Biology.

Characterization of a temperature-sensitive mutant of a ubiquitin-conjugating enzyme and its use as a heat-inducible degradation signal.

K. Madura, P. Tongaonkar, U. Shinde, 1999, Analytical biochemistry.

The role of RbfA in 16S rRNA processing and cell growth at low temperature in Escherichia coli.

M. Inouye, B. Xia, U. Shinde, 2003, Journal of molecular biology.

Biochemical basis of regulation of human copper-transporting ATPases.

U. Shinde, S. Lutsenko, E. Leshane, 2007, Archives of biochemistry and biophysics.

Positive selection dictates the choice between kinetic and thermodynamic protein folding and stability in subtilases.

Y. Yabuta, U. Shinde, Ezhilkani Subbian, 2004, Biochemistry.

Folding Pathway Mediated by an Intramolecular Chaperone

Y. Yabuta, U. Shinde, C. Oiry, 2003, The Journal of Biological Chemistry.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

M. Dai, R. Sears, John E. Klimek, 2023, Nucleic acids research.

Backbone dynamics of the natively unfolded pro-peptide of subtilisin by heteronuclear NMR relaxation studies

M. Inouye, J. Baum, U. Shinde, 2001, Journal of biomolecular NMR.

Pacritinib, a Dual FLT3/JAK2 Inhibitor, Reduces Irak-1 Signaling in Acute Myeloid Leukemia

B. Druker, J. Singer, A. Agarwal, 2015 .

Orthogonal Versatile Interacting Peptide Tags for Imaging Cellular Proteins

Miguel Macias-Contreras, K. Beatty, U. Shinde, 2022, bioRxiv.

Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs*

P. Yates, Radika Soysa, Isaac P. Forquer, 2013, The Journal of Biological Chemistry.

Identification of a pH Sensor in the Furin Propeptide That Regulates Enzyme Activation*

G. Thomas, C. Hung, L. Thomas, 2006, Journal of Biological Chemistry.

Intramolecular chaperones and protein folding.

M. Inouye, U. Shinde, 1993, Trends in biochemical sciences.

Protein Folding Mediated by an Intramolecular Chaperone: Energy Landscape for Unimolecular Pro-Subtilisin E Maturation

U. Shinde, Danielle M. Williamson, Ezhilkani Subbian, 2015 .

Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.

G. Thomas, U. Shinde, J. Elferich, 2012, Journal of molecular biology.

Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin.

G. Thomas, U. Shinde, 2011, Methods in molecular biology.

Folding pathway mediated by an intramolecular chaperone: intrinsically unstructured propeptide modulates stochastic activation of subtilisin.

Y. Yabuta, U. Shinde, Ezhilkani Subbian, 2005, Journal of molecular biology.

Folding Pathway Mediated by an Intramolecular Chaperone

M. Inouye, U. Shinde, Xuan Fu, 2000, The Journal of Biological Chemistry.

An ab Initio Structural Model of a Nucleoside Permease Predicts Functionally Important Residues*

S. Landfear, S. Arastu‐Kapur, R. Valdés, 2009, The Journal of Biological Chemistry.

Both sequence and context are important for flagellar targeting of a glucose transporter

S. Landfear, K. Tran, U. Shinde, 2012, Journal of Cell Science.

Resistance Profile and Structural Modeling of Next-Generation ROS1 Tyrosine Kinase Inhibitors

Kristen L Jones, S. Kaech, R. Somwar, 2021, Molecular Cancer Therapeutics.

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

M. Ladanyi, A. Drilon, R. Somwar, 2020, Communications Biology.

The Lumenal Loop Met672–Pro707 of Copper-transporting ATPase ATP7A Binds Metals and Facilitates Copper Release from the Intramembrane Sites*

U. Shinde, S. Lutsenko, R. Tsivkovskii, 2011, The Journal of Biological Chemistry.

Functional analysis of the propeptides of subtilisin E and aqualysin I as intramolecular chaperones

M. Inouye, H. Takagi, Y. Yabuta, 2001, FEBS letters.

A Pathway for Conformational Diversity in Proteins Mediated by Intramolecular Chaperones*

M. Inouye, U. Shinde, Xuan Fu, 1999, The Journal of Biological Chemistry.

Cysteine Cross-linking Defines the Extracellular Gate for the Leishmania donovani Nucleoside Transporter 1.1 (LdNT1.1)*

S. Landfear, R. Valdés, U. Shinde, 2012, The Journal of Biological Chemistry.

Identification of the Intracellular Gate for a Member of the Equilibrative Nucleoside Transporter (ENT) Family*

S. Landfear, R. Valdés, U. Shinde, 2014, The Journal of Biological Chemistry.

Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation

U. Shinde, J. Elferich, Danielle M. Williamson, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aberrant Folding of a Mutant Stat5b Causes Growth Hormone Insensitivity and Proteasomal Dysfunction*

V. Hwa, P. Rotwein, W. Skach, 2006, Journal of Biological Chemistry.

Spatiotemporal Activation of Furin Propeptide-encoded pH Sensor Regulates The Mechanism by Which a Protein Structure and Folding :

U. Shinde, J. Elferich, G. Thomas, 2013 .

A Broccoli aptamer chimera yields a fluorescent K+ sensor spanning physiological concentrations.

M. Davare, Pushkar Shinde, U. Shinde, 2021, Chemical communications.

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

M. Davare, Pushkar Shinde, K. Nusser, 2023, EMBO molecular medicine.

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

H. Ploegh, E. Barklis, F. Tafesse, 2023, bioRxiv.

Substrate-induced activation of a trapped IMC-mediated protein folding intermediate

M. Inouye, U. Shinde, Xuan Fu, 2001, Nature Structural Biology.

Can the topological distribution of membrane spanning amino acid residues be responsible for the recognition of signal peptides by signal peptide peptidases?

U. Shinde, 1990, Bioscience reports.

Molecular biology, genetics and biochemistry of the repulsive guidance molecule family.

P. Rotwein, U. Shinde, C. Severyn, 2009, The Biochemical journal.

Subtle sequence variations alter tripartite complex kinetics and G-quadruplex dynamics in RNA aptamer Broccoli.

M. Davare, U. Shinde, Jonathan C Savage, 2020, Chemical communications.

A ribose modification of Spinach aptamer accelerates lead(ii) cation association in vitro.

M. Davare, H. Bächinger, Pushkar Shinde, 2019, Chemical communications.

Monoubiquitination Is Critical for Ovarian Tumor Domain-containing Ubiquitin Aldehyde Binding Protein 1 (Otub1) to Suppress UbcH5 Enzyme and Stabilize p53 Protein*

Yuhuang Li, M. Dai, L. David, 2014, The Journal of Biological Chemistry.

COMMD1 Forms Oligomeric Complexes Targeted to the Endocytic Membranes via Specific Interactions with Phosphatidylinositol 4,5-Bisphosphate*

U. Shinde, S. Lutsenko, Clinton T. Morgan, 2009, Journal of Biological Chemistry.

Both sequence and context are important for flagellar targeting of a glucose transporter

S. Landfear, K. Tran, U. Shinde, 2012, Journal of Cell Science.

Folding pathway mediated by an intramolecular chaperone: dissecting conformational changes coincident with autoprocessing and the role of Ca(2+) in subtilisin maturation.

M. Inouye, H. Takagi, Y. Yabuta, 2002, Journal of biochemistry.