J. Grandl

发表

Temperature-activated ion channels in neural crest cells confer maternal fever–associated birth defects

N. Katsanis, Chunlei Liu, E. Benner, 2017, Science Signaling.

The Pore-Domain of TRPA1 Mediates the Inhibitory Effect of the Antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole

R. Latorre, J. Grandl, Hans J. Moldenhauer, 2014, PloS one.

Physics of mechanotransduction by Piezo ion channels

Michael Young, J. Grandl, A. Lewis, 2022, The Journal of general physiology.

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

A. Patapoutian, A. Dubin, B. Coste, 2017, Neuron.

The energetics of rapid cellular mechanotransduction

S. Zauscher, J. Grandl, A. Lewis, 2021, bioRxiv.

Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

J. Grandl, A. Lewis, Jason Wu, 2017, Trends in biochemical sciences.

Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes

Mariana Gómez-Schiavon, Charles A. Gersbach, Nicolas E. Buchler, 2019, Cell reports.

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.

J. Grandl, A. Lewis, Alisa F Cui, 2017, Cell reports.

Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap

J. Grandl, A. Lewis, 2020, Cell reports.

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

Ashley N. Martfeld, J. Grandl, A. Lewis, 2017, Cell reports.

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

J. Grandl, A. Lewis, 2015, eLife.

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Frederick Sachs, Farshid Guilak, Kellie N. Beicker, 2014, Proceedings of the National Academy of Sciences.

The energetics of rapid cellular mechanotransduction

S. Zauscher, J. Grandl, A. Lewis, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Balboa Binds to Pickpocket In Vivo and Is Required for Mechanical Nociception in Drosophila Larvae

Richard Y. Hwang, A. Tsubouchi, Stephanie E. Mauthner, 2014, Current Biology.

Piezos are pore-forming subunits of mechanically activated channels

Sung Eun Kim, Manuela Schmidt, Mauricio Montal, 2011, Nature.

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

Sung Eun Kim, Badry Bursulaya, A. Patapoutian, 2010, Nature Neuroscience.

TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity

E. Iversen, J. Grandl, Jason O. Sosa-Pagán, 2017, Scientific Reports.

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

A. Patapoutian, R. Latorre, J. Grandl, 2014, Neuron.

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

A. Patapoutian, Matt J. Petrus, Hongzhen Hu, 2009, Proceedings of the National Academy of Sciences.

Pore region of TRPV3 ion channel is specifically required for heat activation

Manuela Schmidt, A. Patapoutian, Matt J. Petrus, 2008, Nature Neuroscience.

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel.

H. Vogel, C. Danelon, R. Hovius, 2007, Biochimica et biophysica acta.

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

H. Vogel, C. Danelon, R. Hovius, 2006, European Biophysics Journal.

Localized force application reveals mechanically sensitive domains of Piezo1

Jason Wu, J. Grandl, Raman Goyal, 2016, Nature Communications.

A cellular mechanism for age-induced itch

J. Grandl, A. Lewis, 2018, Science.

Fluorescent epibatidine agonists for neuronal and muscle-type nicotinic acetylcholine receptors.

D. Bertrand, H. Vogel, S. Bertrand, 2007, Angewandte Chemie.

Piezo1 ion channels inherently function as independent mechanotransducers

J. Grandl, A. Lewis, 2021, bioRxiv.

The energetics of rapid cellular mechanotransduction

S. Zauscher, J. Grandl, A. Lewis, 2023, Biophysical journal.

The energetics of rapid cellular mechanotransduction

S. Zauscher, J. Grandl, A. Lewis, 2022, bioRxiv.

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

A. Patapoutian, R. Latorre, J. Grandl, 2014, Neuron.

Platform Z: Mechanosensitive & TRP Channels

J. Mcgeown, A. Patapoutian, Matt J. Petrus, 2010 .

Piezo1 ion channels are capable of conformational signaling

J. Grandl, A. Lewis, Marie E. Cronin, 2024, Neuron.

Subconductance states add complexity to Piezo1 gating model.

J. Grandl, Marie E. Cronin, 2024, Trends in biochemical sciences.

An Internal Dial for Sensitivity and Gain of Rapid Mechanotransduction

J. Grandl, A. Lewis, 2020, Neuron.

CFTR Gating

C. Carlson, R. Latorre, I. Sjaastad, 2015 .