Jianjun Chang

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Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Coeruleus Pathology and Nonmotor Features of Parkinson's Disease

Kirsten A. Porter-Stransky, M. Tansey, B. Giasson, 2020, The Journal of Neuroscience.

Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595

M. Tansey, C. Barnum, Lori N. Eidson, 2019, Brain, Behavior, and Immunity.

Lysosome and Inflammatory Defects in GBA1‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition

M. Tansey, J. Tomlinson, M. LaVoie, 2020, Movement disorders : official journal of the Movement Disorder Society.

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

M. Goldberg, M. Tansey, Jianjun Chang, 2011, PloS one.

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

Dean P. Jones, M. Tansey, D. Walker, 2019, Alzheimer's Research & Therapy.

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

Dean P. Jones, M. Tansey, D. Walker, 2017, Brain, Behavior, and Immunity.

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

F. Scheperjans, L. Paulin, V. Hertzberg, 2021, Molecular Neurodegeneration.

Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease

S. Factor, H. Payami, V. Hertzberg, 2018, Movement disorders : official journal of the Movement Disorder Society.

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

F. Scheperjans, L. Paulin, V. Hertzberg, 2020, medRxiv.

Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.

A. Levey, N. Seyfried, M. Gearing, 2012, Journal of proteome research.

Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1

C. Gonzalez-Islas, C. Aalkjaer, L. Jeffers, 2020, Scientific Reports.

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

M. Tansey, C. Norris, K. MacPherson, 2017, Neurobiology of Disease.

Low-dose IL-2 improved clinical symptoms by restoring reduced regulatory T cells in patients with refractory rheumatoid arthritis: A randomized controlled trial

Xiao-feng Li, Jianjun Chang, Jing Luo, 2022, Frontiers in Immunology.

Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology

A. Keshavarzian, M. Tansey, W. Caudle, 2021, Acta neuropathologica communications.

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

K. Marek, B. Mollenhauer, M. Frasier, 2017, Journal of Neuroinflammation.

Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer’s disease mouse model

M. Tansey, C. Norris, K. MacPherson, 2023, Frontiers in Cellular Neuroscience.

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

Robert V Farese, X. Chen, M. Tansey, 2013, The Journal of Neuroscience.

Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats.

Xi Chen, M. Tansey, Jaegwon Chung, 2014, Journal of Parkinson's disease.

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

M. Tansey, Jessica E Rexach, K. MacPherson, 2022, Frontiers in Immunology.

Regulation of microglia effector functions by tumor necrosis factor signaling

M. Tansey, Jianjun Chang, Jae-Kyung Lee, 2012, Glia.

Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1

C. Gonzalez-Islas, C. Aalkjaer, L. Jeffers, 2020, Scientific Reports.

M. Tansey, K. Shepherd, Jaegwon Chung, 2015, Neurobiology of Aging.

Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study

B. Ritz, S. Factor, J. Bronstein, 2015, npj Parkinson's Disease.

LRRK2 levels in immune cells are increased in Parkinson’s disease

S. Factor, A. West, J. Boss, 2017, npj Parkinson's Disease.

The second generation mixed lineage kinase-3 (MLK3) inhibitor CLFB-1134 protects against neurotoxin-induced nigral dopaminergic neuron loss

M. Tansey, H. Gelbard, W. Caudle, 2019, Experimental Neurology.

M. Tansey, K. Shepherd, Jaegwon Chung, 2015, Neurobiology of Aging.

Transgenic Mice Expressing Human a -Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson ’ s Disease

Kirsten A. Porter-Stransky, M. Tansey, B. Giasson, 2020 .

Transgenic Mice Expressing Human a -Synuclein in Noradrenergic Neurons Develop Locus Coeruleus Pathology and Nonmotor Features of Parkinson ’ s Disease

Kirsten A. Porter-Stransky, M. Tansey, B. Giasson, 2022 .

Loss of progranulin leads to dysregulation of innate and adaptive immune cell populations, increased susceptibility to experimental colitis, and brain infiltration of peripheral immune cells

M. Tansey, S. Prokop, Nicholas H. Varvel, 2020 .

Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer’s disease

M. Tansey, Maria Elizabeth De Sousa Rodrigues, Jianjun Chang, 2024, bioRxiv.