C. Spanka

发表

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.

Guido Koch, Connor W. Coley, K. Jensen, 2017, Chemical communications.

Oxysterols direct immune cell migration via EBI2

P. Schultz, J. Cyster, K. Seuwen, 2011, Nature.

A tunable hydrogel for encapsulation and controlled release of bioactive proteins.

M. Delgado, K. Janda, P. Wentworth, 2002, Biomacromolecules.

Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity

M. Renatus, C. Wiesmann, F. Villard, 2020 .

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

M. Fendt, I. Vranesic, T. Troxler, 2010, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin

K. Gademann, D. Hoepfner, E. Schmitt, 2019, Chembiochem : a European journal of chemical biology.

Solid-phase rhodium carbenoid reactions: an N-H insertion route to a diverse series of oxazoles.

K. Janda, B. Clapham, C. Spanka, 2001, Organic letters.

Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent.

O. Shimomura, K. Janda, S. Mahajan, 2002, Journal of combinatorial chemistry.

Preparation of new microgel polymers and their application as supports in organic synthesis.

K. Janda, B. Clapham, C. Spanka, 2002, The Journal of organic chemistry.

Nucleophilic addition of lithiated phenyl trimethylsilylmethyl sulfide to activated olefins: a facile synthesis of 2-(functionally) substituted silylcyclopropanes

E. Schaumann, C. Spanka, C. Friese, 1986 .

Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network.

B. Faller, V. Tschinke, C. Spanka, 2000, Journal of medicinal chemistry.

Synthesis of N-{4-[2-(2-Amino-5,6-dihydro-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)- ethyl]benzoyl}-l-glutamic Acid: A Ring-Contracted Analogue of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid†

C. Spanka, E. Taylor, A. Young, 1996 .

Soluble polymer-supported methods for combinatorial and organic synthesis.

P. Wentworth, C. Spanka, 2002, Methods in molecular biology.

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Pascal Furet, C. Schnell, J. Brueggen, 2011, Journal of medicinal chemistry.

Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

C. Carlberg, M. Chiesi, C. Spanka, 1998, Molecular pharmacology.

A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity.

M. Delgado, K. Janda, P. Wentworth, 2002, Journal of the American Chemical Society.

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

P. Niyomrattanakit, Yen-Liang Chen, P. Shi, 2009, Journal of medicinal chemistry.

3-Alkylidene-2-azetidinethiones: Useful Intermediates for the Synthesis of 3-Substituted 2-Azetidinethiones†

E. Schaumann, J. Nieschalk, C. Spanka, 2006 .

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

D. O'connor, S. Watson, S. Charlton, 2014, Bioorganic & medicinal chemistry letters.

Nucleophilic Addition of Lithiated Phenyl Trimethylsilylmethyl Sulfide to Activated Olefins. A Facile Synthesis of 2-(Functionally) Substituted Silylcyclopropanes

E. Schaumann, C. Spanka, C. Friese, 1987 .