C. Griffiths-Jones

发表

A Flow Process for the Multi‐Step Synthesis of the Alkaloid Natural Product Oxomaritidine: A New Paradigm for Molecular Assembly.

S. Ley, S. Saaby, I. Baxendale, 2006 .

Microwave-Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous-Flow Transformations.

S. Ley, I. Baxendale, C. Griffiths-Jones, 2006 .

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

G. Chessari, P. Williams, E. Chiarparin, 2017, Journal of medicinal chemistry.

Carbenium ion trapping using sulfonamides: an acid-catalysed synthesis of pyrrolidines by intramolecular hydroamination

D. Knight, C. Griffiths-Jones, 2010 .

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

K. Kondo, A. Woolford, T. Heightman, 2022, ACS medicinal chemistry letters.

Total synthesis of antascomicin B.

S. Ley, C. Griffiths-Jones, Martin D. Smith, 2005, Angewandte Chemie.

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.

Steven V Ley, Ian R Baxendale, S. Ley, 2006, Chemistry.

Piperidines from acid-catalysed cyclisations: Pitfalls, solutions and a new ring contraction to pyrrolidines

D. Knight, C. Griffiths-Jones, Abdul Hadi Aldmairi, 2017 .

A total synthesis of (±)-α-cyclopiazonic acid using a cationic cascade as a key step

D. Knight, C. Griffiths-Jones, 2011 .

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.

H. Willems, G. Saxty, T. Davies, 2016, Journal of medicinal chemistry.

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

C. Murray, V. Berdini, L. Fazal, 2021, Journal of medicinal chemistry.

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

C. Murray, V. Berdini, J. Castro, 2018, Journal of medicinal chemistry.

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly.

S. Ley, S. Saaby, I. Baxendale, 2006, Chemical communications.

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.

Paul N. Mortenson, W. Rumsey, H. Willems, 2019, Journal of medicinal chemistry.

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.

M. Verdonk, W. Rumsey, H. Willems, 2021, Journal of medicinal chemistry.

Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.

Steven V Ley, Mark D. Hopkin, S. Ley, 2007, Journal of combinatorial chemistry.

Preparation of the neolignan natural product grossamide by a continuous-flow process

Steven V. Ley, Ian R. Baxendale, S. Ley, 2006 .