J. Galivan

发表

Reversibly permeable hepatoma cells in culture.

M. Balińska, W. Samsonoff, J. Galivan, 1982, Biochimica et biophysica acta.

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates.

J. Kremer, B. Kamen, J. Galivan, 1986, Arthritis and rheumatism.

The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates.

D. Priest, M. Rhee, J. Galivan, 1987, Advances in enzyme regulation.

Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates.

M. Rhee, J. Galivan, 1995, Biochemical pharmacology.

Acquisition of Resistance to Antifolates Caused by Enhanced γ-Glutamyl Hydrolase Activity

Ying Wang, M. Rhee, J. Galivan, 1993 .

Folate analogues. 33. Synthesis of folate and antifolate poly-gamma-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells.

J. Galivan, R. Kisliuk, Y. Gaumont, 1990, Journal of medicinal chemistry.

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.

G. Maley, F. Maley, J. Galivan, 1976, Biochemistry.

Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity.

Y. Rustum, F. Hausheer, S. Cao, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.

E. Schneider, J. Galivan, T. Ryan, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation.

M. Rhee, J. Galivan, M. Fasco, 1988, Archives of biochemistry and biophysics.

Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.

S. Kerwar, G. P. Beardsley, A. Rosowsky, 1992, Cancer research.

Identification, Cloning, and Sequencing of a cDNA Coding for Rat -Glutamyl Hydrolase (*)

J. Galivan, T. Ryan, R. Yao, 1996, The Journal of Biological Chemistry.

Transport and Metabolism of Methotrexate in Normal and Resistant Cultured Rat Hepatoma Cells1

J. Galivan, 2006 .

Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy

T. Tsukamoto, J. Coward, J. Galivan, 2004, Investigational New Drugs.

Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites.

M. Rhee, J. Coward, J. Galivan, 1996, Biochemical pharmacology.

Hormonal alteration of methotrexate and folate polyglutamate formation in cultured hepatoma cells.

J. Galivan, 1984, Archives of biochemistry and biophysics.

Regulatory aspects of the glutamylation of methotrexate in cultured hepatoma cells.

J. Galivan, Z. Nimec, 1983, Archives of biochemistry and biophysics.

Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content.

M. Balińska, J. Galivan, Z. Nimec, 1983, Biochemical pharmacology.

Characteristics of methotrexate polyglutamate formation in cultured hepatic cells.

M. Balińska, J. Galivan, Z. Nimec, 1982, Archives of biochemistry and biophysics.

Factors controlling the concentrations of methotrexate in cultured hepatic cells.

M. Fox, M. Balińska, J. Galivan, 1982, Advances in enzyme regulation.

Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro.

J. Coward, M. Balińska, J. Galivan, 1981, Cancer research.

Activation of methionine synthase: further characterization of flavoprotein system.

F. M. Huennekens, J. Galivan, K. Fujii, 1977, Archives of biochemistry and biophysics.

Structural organization of the human gamma-glutamyl hydrolase gene.

J. Galivan, D. Yin, K. Chave, 1999, Gene.

Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences.

F. Sirotnak, K. Roy, J. Galivan, 1998, Gene.

Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.

G. Maley, F. Maley, D. Priest, 1990, Cancer research.

Purification and properties of T2 bacteriophage-induced thymidylate synthetase.

G. Maley, F. Maley, J. Galivan, 1974, Biochemistry.

Methylmalonyl-CoA decarboxylase: partial purification and enzymatic properties.

J. Galivan, S. Allen, 1968, Archives of biochemistry and biophysics.

Hepatic parenchymal cell glutamylation of methotrexate studied in monolayer culture.

M. Rhee, J. Galivan, A. Pupons, 1986, Cancer research.

Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor

R. Jackson, S. Webber, M. Rhee, 2004, Cancer Chemotherapy and Pharmacology.

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

J. Galivan, 1979, Cancer research.

The absence of γ‐glutamyltransferase activity in transport‐dependent methotrexate‐resistant hepatoma cells

R. Rej, J. Galivan, T. Johnson, 1987, International journal of cancer.

The temporal expression of T2r + bacteriophage genes in vivo and in vitro.

F. Maley, R. B. Trimble, J. Galivan, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase.

F. Maley, J. Galivan, C. Baugh, 1977, Archives of biochemistry and biophysics.

Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.

R. Ferone, F. Maley, J. Galivan, 1989, Journal of medicinal chemistry.

Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms.

J. Galivan, K. Chave, T. Ryan, 2003, Gene.

Studies on the reactivity of the essential cysteine of thymidylate synthetase.

F. Maley, J. Galivan, J. Noonan, 1977, Archives of biochemistry and biophysics.

Transport of methotrexate of primary cultures of rat hepatocytes: stimulation of uptake in vitro by the presence of hormones in the medium.

J. Galivan, 1981, Archives of biochemistry and biophysics.

Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.

J. Galivan, S. Allen, 1968, The Journal of biological chemistry.

The effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei.

G. Maley, F. Maley, J. Galivan, 1975, Biochemistry.

Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.

M. Rhee, J. Galivan, J. R. Piper, 1992, Journal of Medicinal Chemistry.

Prevention of colchicine toxicity to cultured rat hepatocytes by glucagon, hydrocortisone and insulin.

J. Galivan, 1981, Experimental cell research.

Membrane characteristics of adult rat liver parenchymal cells in primary monolayer culture

A. Tarentino, J. Galivan, glutinin Wga, 1980, In Vitro.

5-Methyltetrahydrofolate transport by hepatoma cells and methotrexate-resistant sublines in culture.

J. Galivan, 1981, Cancer research.

Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.

D. Priest, G. P. Beardsley, M. Bunni, 1995, Cancer research.

Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.

S. Kerwar, A. Oronsky, M. Rhee, 1988, Cancer research.

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

J. Galivan, 1980, Molecular pharmacology.

The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.

D. Priest, M. Bunni, M. Rhee, 1989, The Journal of biological chemistry.

Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.

M. Rhee, J. Galivan, Z. Nimec, 1987, Cancer research.

Amino acid sequence at the FdUMP binding site of thymidylate synthetase.

G. Maley, F. Maley, J. Galivan, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Proliferation-dependency of folylpolyglutamyl synthetase activity in maturating luminal epithelial cells of mouse small intestine.

F. Sirotnak, J. Galivan, T. Johnson, 1988, Biochemical pharmacology.

Effect of a Novel Antifolate, Nα-(4-Amino-4-Deoxypteroyl)-Nδ-Hemiphthaloyl-L-Ornithbsfe (PT523), On Growth of H35 Rat Hepatoma and HEPG2 Human Hepatoma Cells

M. Sherman, A. Rosowsky, M. Rhee, 1993 .

The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture.

D. Priest, J. Whiteley, M. Bunni, 1991, Advances in experimental medicine and biology.

CCRF-CEM Cell Lines Derived from Human Lymphoblastic Leukemia Multifactorial Resistance to 5 , 10-Dideazatetrahydrofolic Acid in Updated Version

Jennifer, D. Priest, Bárbara, 2006 .

A Comparison of Hplc and Ternary Complex-Based Assays of Tissue Reduced Folates

D. Priest, M. Bunni, M. Rhee, 1992 .

Studies on the effect of D-penicillamine, gold thioglucose and methotrexate on streptococcal cell wall arthritis.

S. Kerwar, A. Oronsky, N. Rath, 1986, The Journal of rheumatology.

Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.

J. Galivan, T. Johnson, M. G. Nair, 1988, Cancer research.

Effects of folinic acid on hepatoma cells containing methotrexate polyglutamates.

J. Galivan, Z. Nimec, 1983, Cancer research.

Studies of formation and efflux of methotrexate polyglutamates with cultured hepatic cells.

M. Balińska, J. Galivan, 1983, Advances in experimental medicine and biology.

Recovery of sealed H35 hepatoma cells in monolayer culture following lysolecithin permeabilization

J. Galivan, 1983 .

The Chromophore and Polypeptide Composition of Aplysia Ink.

R. Maccoll, D. Berns, J. Galivan, 1990, The Biological bulletin.

Interaction of methotrexate poly(L-lysine) with transformed hepatic cells in culture.

J. Whiteley, M. Balińska, J. Galivan, 1982, Archives of biochemistry and biophysics.

Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.

A. Rosowsky, M. Rhee, J. Galivan, 1994, Molecular pharmacology.

Secretion of gamma-glutamyl hydrolase in vitro.

J. Galivan, J. McGuire, R. Rotundo, 1991, Cancer research.

Dihydrofolate-mediated reversal of methotrexate toxicity to hepatoma cells in vitro.

M. Balińska, J. Galivan, C. Kruger-McDermott, 1986, Cancer letters.

Conversion of methotrexate to 7-hydroxymethotrexate and 7-hydroxymethotrexate polyglutamates in cultured rat hepatic cells.

M. Rhee, J. Galivan, 1986, Cancer research.

MEMBRANE CHARACTERISTICS OF PRIMARY HEPATOCYTE CULTURES AND A STABLE HEPATOCARCINOMA CELL LINE *

A. Tarentino, W. Samsonoff, J. Galivan, 1980, Annals of the New York Academy of Sciences.

The effect of methionine on methotrexate metabolism in rat hepatocytes in monolayer culture.

D. Priest, M. Rhee, J. Galivan, 1989, Biochimica et biophysica acta.

The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.

T B Johnson, D. Priest, T. Chou, 1989, Advances in enzyme regulation.

Glutamyl hydrolase and the multitargeted antifolate LY231514

M. Rhee, J. Galivan, T. Ryan, 1999, Cancer Chemotherapy and Pharmacology.

Glutamyl hydrolase. pharmacological role and enzymatic characterization.

M. Rhee, J. Galivan, D. Yin, 2000, Pharmacology & therapeutics.

THE BIOCHEMICAL PROPERTIES OF CARRIER-BOUND METHOTREXATE

B. Chu, J. Whiteley, J. Galivan, 1981 .

Intracellular Location of Thymidylate Synthase and Its State of Phosphorylation*

G. Maley, F. Maley, M. Mckee, 1997, The Journal of Biological Chemistry.

Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase.

F. Maley, J. Galivan, C. Baugh, 1976, Biochemical and biophysical research communications.

Characterization of the human γ-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines

W. Ao, J. Galivan, D. Yin, 2003 .

Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate.

D. Priest, J. Whiteley, M. Rhee, 1991, Archives of biochemistry and biophysics.

Stabilization of cholic acid uptake in primary cultures of hepatocytes by dexamethasone and tocopherol.

J. Galivan, 1982, Archives of biochemistry and biophysics.

Methotrexate in Adjuvant Arthritis

S. Kerwar, J. Galivan, M. Rehder, 1986 .

Two novel HPLC methods which rapidly detect the substrates and cleavage products of gamma-glutamyl hydrolase.

J. Galivan, R. Rotundo, T. Ryan, 1993, Advances in experimental medicine and biology.

Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity.

M. Rhee, J. Galivan, M. G. Nair, 1993, Cancer research.

Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines.

W. Ao, J. Galivan, D. Yin, 2003, Gene.

Molecular Modeling and Site-directed Mutagenesis Define the Catalytic Motif in Human γ-Glutamyl Hydrolase*

I. Auger, J. Galivan, K. Chave, 2000, The Journal of Biological Chemistry.

Glutamyl hydrolase: properties and pharmacologic impact.

M. Rhee, J. Galivan, K. Chave, 1999, Seminars in oncology.

Characterization of human cellular gamma-glutamyl hydrolase.

M. Rhee, J. Galivan, K. Chave, 1998, Molecular pharmacology.

Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase.

I. Auger, J. Galivan, K. Chave, 2000, Journal of Biological Chemistry.

Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells.

M. Rhee, J. Galivan, R. Yao, 1995, Molecular Pharmacology.

Secretion of γ-Glutamyl Hydrolase in Vitro

J. Galivan, J. McGuire, R. Rotundo, 1991 .

Characterization of Human Cellular g-Glutamyl Hydrolase

M. Rhee, J. Galivan, K. Chave, 1998 .

Glutamylation of methotrexate in hepatoma cells in vitro: regulation and the development of specific inhibitors.

J. Coward, J. Galivan, J. McGuire, 1985, Advances in Enzyme Regulation.

The properties of the secreted γ-glutamyl hydrolases from H35 hepatoma cells

Ying Wang, J. Dias, J. Galivan, 1993 .

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

James Inglese, J. Coward, J. Galivan, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Studies on the effect of low dose methotrexate on rat adjuvant arthritis.

S. Kerwar, A. Oronsky, J. Silkworth, 1985, The Journal of rheumatology.

Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studies.

A. Rosowsky, J. Galivan, J. Freisheim, 1985, Molecular pharmacology.

Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells.

M. Rhee, J. Coward, J. Galivan, 1992, Molecular pharmacology.

Resolution of the methionine synthetase system from Escherichia coli K-12.

F. M. Huennekens, J. Galivan, 1970, Biochemical and biophysical research communications.

The properties and function of γ-glutamyl hydrolase and poly-γ-glutamate

Ying Wang, J. Galivan, J. Freisheim, 1993 .