Novalia Pishesha

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Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

Harvey F Lodish, Jiahai Shi, Hidde L Ploegh, 2014, Proceedings of the National Academy of Sciences.

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

Lestat R. Ali, H. Ploegh, U. V. von Andrian, 2018, Cancer Immunology Research.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

H. Lodish, H. Ploegh, Marsha C. Wibowo, 2017, Proceedings of the National Academy of Sciences.

Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice

H. Ploegh, Djenet Bousbaine, Paul W. Rothlauf, 2021, Frontiers in Immunology.

Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments

H. Ploegh, J. Ingram, M. Dougan, 2020, Cancer Immunology Research.

Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration

I. Conboy, P. Paliwal, Novalia Pishesha, 2012, Aging.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

F. Alt, B. Haynes, D. Montefiori, 2022, bioRxiv.

Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity

H. Lodish, H. Ploegh, Novalia Pishesha, 2020, bioRxiv.

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

Carly K. Schissel, D. Irvine, H. Ploegh, 2020, bioRxiv.

An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion

F. Alt, B. Haynes, D. Montefiori, 2022, Science Immunology.

Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes

H. Ploegh, G. González-Sapienza, Leif S. Ludwig, 2021, Nature Biomedical Engineering.

Single domain antibody-antigen adducts that target Class II MHC induce antigen-specific tolerance

H. Ploegh, Leif S. Ludwig, A. Islam, 2021 .

Localized CD47 blockade enhances immunotherapy for murine melanoma

Lestat R. Ali, K. Garcia, H. Ploegh, 2017, Proceedings of the National Academy of Sciences.

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

H. Lodish, C. Shoemaker, J. Mukherjee, 2017, Nature Communications.

Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms

H. Ploegh, A. Bhan, Xin Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

R. Hynes, H. Ploegh, N. Jailkhani, 2019, Proceedings of the National Academy of Sciences.

Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome

K. V. Van Vliet, Z. Poon, Novalia Pishesha, 2018, Stem Cell Research & Therapy.

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

S. Elledge, D. Irvine, R. Spreafico, 2022, Cell.

Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction

K. Semba, Yasuyuki Fujita, T. Maruyama, 2021, Nature Immunology.

Efficient CRISPR-Cas9 mediated gene disruption in primary erythroid progenitor cells

H. Lodish, Anirudh Natarajan, Jiahai Shi, 2016, Haematologica.

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

E. Crestani, T. Chatila, Xu G. Yu, 2021, Immunity.

A guide to antigen processing and presentation

H. Ploegh, Novalia Pishesha, Thibault J. Harmand, 2022, Nature Reviews Immunology.

A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

S. Whelan, H. Ploegh, Louis-Marie Bloyet, 2021, Proceedings of the National Academy of Sciences.

Functional analyses and single cell immunoprofiling uncover sex-specific differences in SARS-CoV2 immune memory development

A. Regev, R. Xavier, O. Rozenblatt-Rosen, 2022, Research square.

Sortase A: A Model for Transpeptidation and Its Biological Applications.

H. Ploegh, J. Ingram, Novalia Pishesha, 2018, Annual review of cell and developmental biology.

Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells

H. Ploegh, Ross W. Cheloha, Djenet Bousbaine, 2021, The Journal of Immunology.

Transcriptional divergence and conservation of human and mouse erythropoiesis

H. Lodish, P. Thiru, V. Sankaran, 2014, Proceedings of the National Academy of Sciences.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.

K. V. Van Vliet, Z. Poon, Novalia Pishesha, 2017, ACS biomaterials science & engineering.

Correction for Xie et al., Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

R. Hynes, N. Jailkhani, S. Rickelt, 2019, Proceedings of the National Academy of Sciences.

An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance

Carly K. Schissel, D. Irvine, H. Ploegh, 2021, Proceedings of the National Academy of Sciences.

Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.

H. Ploegh, M. Truttmann, J. Ingram, 2017, Current protocols in protein science.

Nanobodies as in vivo, non-invasive, imaging agents

Hidde L Ploegh, Thibault J Harmand, Ashraful Islam, 2021, RSC chemical biology.

Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells.

H. Ploegh, Novalia Pishesha, Thibault J. Harmand, 2021, ACS chemical biology.

Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.

K. V. Van Vliet, Z. Poon, Novalia Pishesha, 2017, ACS biomaterials science & engineering.

Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration

I. Conboy, P. Paliwal, Novalia Pishesha, 2012, Aging.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors

H. Ploegh, K. Wucherpfennig, Novalia Pishesha, 2024, Frontiers in immunology.

Nanobody-targeted conditional antimicrobial therapeutics

H. Ploegh, Novalia Pishesha, Chayanon Ngambenjawong, 2024, bioRxiv.