R. Hansen

发表

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.

Yi Liu, Jun Feng, Pingda Ren, 2016, Cancer discovery.

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

P. Zarrinkar, K. Yu, D. Brehmer, 2018, Cell.

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

Neal Rosen, N. Rosen, P. Lito, 2016, Science.

An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors

Yi Liu, P. Zarrinkar, M. R. Janes, 2018, Scientific Reports.

The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors

Yi Liu, Jun Feng, Pingda Ren, 2018, Nature Structural & Molecular Biology.

An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors

P. Zarrinkar, Yi Liu, M. R. Janes, 2018, Scientific Reports.

The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors

P. Zarrinkar, U. Peters, Yi Liu, 2018, Nature Structural & Molecular Biology.

Abstract 5168: KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors

K. Yu, Tao Wu, F. Burrows, 2017 .

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.

U. Peters, M. Patricelli, Yi Liu, 2016, Cancer discovery.