C. Unson

发表

Multiple-site replacement analogs of glucagon. A molecular basis for antagonist design.

K. J. Fitzpatrick, R. B. Merrifield, C. Unson, 1994, The Journal of biological chemistry.

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.

A. Shenker, A. Spiegel, P. Goldsmith, 1991, Transactions of the Association of American Physicians.

Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Immunolocalization of G protein alpha-subunits in the Drosophila CNS

A. Spiegel, P. Goldsmith, M. Forte, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

G. Milligan, P. Gierschik, H. Malech, 1987, The Journal of biological chemistry.

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist

R. B. Merrifield, C. Unson, E. Gurzenda, 1989, Peptides.

Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.

R. B. Merrifield, T. Sakmar, P. Goldsmith, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets.

G. Weir, J. Habener, T. Kieffer, 1996, Endocrinology.

The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.

M. Caron, G. Milligan, J. Benovic, 1987, The Journal of biological chemistry.

Glucagon‐mediated internalization of serine‐phosphorylated glucagon receptor and Gsα in rat liver

B. Desbuquois, C. Merlen, S. Fabrega, 2006, FEBS letters.

Synthetic peptide antagonists of glucagon.

R. B. Merrifield, D. Andreu, C. Unson, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Expression of glucagon receptors in tetracycline‐inducible HEK293S GnT1− stable cell lines: An approach toward purification of receptor protein for structural studies

C. Unson, 2008, Biopolymers.

Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl‐terminal decapeptide

W. Simonds, A. Spiegel, P. Goldsmith, 1989, FEBS letters.

Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

D. Cooper, A. Spiegel, P. Goldsmith, 1990, Brain Research.

Active site of C3a anaphylatoxin: contributions of the lipophilic and orienting residues.

B. W. Erickson, T. Hugli, C. Unson, 1984, Biochemistry.

The active site of human C4a anaphylatoxin.

B. W. Erickson, T. Hugli, C. Unson, 1983, Molecular immunology.

Positively Charged Residues at Positions 12, 17, and 18 of Glucagon Ensure Maximum Biological Potency*

R. B. Merrifield, C. Unson, Cui-Rong Wu, 1998, The Journal of Biological Chemistry.

Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding.

H. Kim, T. Sakmar, C. Unson, 1994, The Journal of biological chemistry.

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.

G. Milligan, P. Gierschik, A. Spiegel, 1987, Biochemistry.

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

W. Simonds, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins

W. Simonds, T. L. Jones, A. Spiegel, 1992 .

Glucagon and the Glucagon Receptor: Merrifield Years at the Interface of Chemistry and Biology

C. Unson, 2007, International Journal of Peptide Research and Therapeutics.

An ab initio study of non-peptide glucagon receptor antagonists

A. Sapse, C. Unson, R. Rothchild, 2003 .

Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.

T. Miyazaki, Lada Krilov, B. Bouscarel, 2008, American journal of physiology. Cell physiology.

Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins.

N. Lee, T. Miyazaki, Lada Krilov, 2011, Experimental cell research.

High‐fat diet‐induced hepatic steatosis reduces glucagon receptor content in rat hepatocytes: potential interaction with acute exercise

J. Lavoie, C. Unson, A. Charbonneau, 2007, The Journal of physiology.

Persistent activation of the alpha subunit of Gs promotes its removal from the plasma membrane.

G. Milligan, C. Unson, G. Milligan, 1989, The Biochemical journal.

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

G. Milligan, M. Houslay, A. Spiegel, 1987, Nature.

An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.

R. Cerione, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors.

G. Milligan, A. Spiegel, P. Goldsmith, 1988, Endocrinology.

Potentiation of glucose-induced insulin release in islets by desHis1[Glu9]glucagon amide.

R. B. Merrifield, C. Unson, H. Kofod, 2009, International journal of peptide and protein research.

Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding.

R. B. Merrifield, C. Unson, K. Ray, 1991, The Journal of biological chemistry.

The role of histidine-1 in glucagon action.

R. B. Merrifield, C. Unson, D. Macdonald, 1993, Archives of biochemistry and biophysics.

Antibodies as Probes of G-Protein Structure and Function

W. Simonds, A. Spiegel, P. Goldsmith, 1990 .

Identification of both Gi2 and a novel, immunologically distinct, form of Go in rat myometrial membranes

G. Milligan, S. Harbon, O. Goureau, 1989, FEBS letters.

GTP analogues cause release of the alpha subunit of the GTP binding protein, GO, from the plasma membrane of NG108-15 cells.

G. Milligan, A. Magee, C. Unson, 1988, Biochemical and biophysical research communications.

THE USE OF SPECIFIC ANTISERA TO STUDY THE DEVELOPMENTAL REGULATION OF GUANINE NUCLEOTIDE BINDING PROTEINS

G. Milligan, P. Gierschik, A. Spiegel, 1987 .

Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.

G. Milligan, F. McKenzie, A. Spiegel, 1988, The Biochemical journal.

GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.

G. Milligan, P. Gierschik, A. Spiegel, 1987, Biochemical and biophysical research communications.

Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.

G. Milligan, A. Spiegel, E. Saggerson, 1987, The Biochemical journal.

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides

J. Falloon, G. Milligan, H. Malech, 1986, FEBS letters.

Identification of an essential serine residue in glucagon: implication for an active site triad.

R. B. Merrifield, C. Unson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of 2-methyl and 2-carboxymethyl derivatives of ornithine and arginine.

B. W. Erickson, C. Unson, 2009, International journal of peptide and protein research.

Molecular determinants of glucagon receptor signaling.

C. Unson, 2002, Biopolymers.

Selective Stabilization of the High Affinity Binding Conformation of Glucagon Receptor by the Long Splice Variant of Gαs *

R. B. Merrifield, T. Sakmar, C. Unson, 2000, The Journal of Biological Chemistry.

Antigenic specificity of a rabbit antiserum raised against the 15–28 segment of thymosin α1

B. W. Erickson, S. Khan, C. Unson, 1986 .

A radioimmunoassay for thymosin alpha-1.

B. W. Erickson, C. Unson, J. G. Wang, 1986, Journal of immunological methods.

G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.

W. Simonds, N. Gautam, A. Spiegel, 1991, The Journal of biological chemistry.

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

W. Simonds, A. Spiegel, J. Codina, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Glucagon-Expressing Neurons within the Retina Regulate the Proliferation of Neural Progenitors in the Circumferential Marginal Zone of the Avian Eye

N. A. Walton, A. Fischer, C. Unson, 2005, The Journal of Neuroscience.

Antibodies against synthetic peptides as probes of G protein structure and function.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Society of General Physiologists series.

Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.

G. Milligan, A. Magee, C. Unson, 1988, The Biochemical journal.

Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).

G. Milligan, J. Knowler, C. Loney, 1990, European journal of pharmacology.

Site-Specific Fluorescent-Labeled Glucagon Analogs: Probes for the Glucagon Receptor,

R. B. Merrifield, M. Fleischer, C. Unson, 1992 .

Roles of aspartic acid 15 and 21 in glucagon action: receptor anchor and surrogates for aspartic acid 9.

R. B. Merrifield, C. Unson, C. R. Wu, 1994, Biochemistry.

Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium*

T. Sakmar, A. Cypess, C. Unson, 1999, The Journal of Biological Chemistry.

Dual mode of glucagon receptor internalization: role of PKCalpha, GRKs and beta-arrestins.

T. Miyazaki, Lada Krilov, Russell D. Williams, 2011 .

The Role of Salt Bridge Formation in Glucagon: An Experimental and Theoretical Study of Glucagon Analogs and Peptide Fragments of Glucagon

A. Sapse, C. Unson, R. Rothchild, 2002, Molecular medicine.

Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling.

R. B. Merrifield, T. Sakmar, B. Yoo, 2002, Biochemistry.

GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells.

G. Milligan, L. Marshall, A. Spiegel, 1988, The Biochemical journal.

Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor

R. B. Merrifield, T. Sakmar, P. Goldsmith, 1995, The Journal of Biological Chemistry.

Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

T. Hökfelt, R. Cortės, M. Schalling, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase

R. B. Merrifield, T. Sakmar, E. D. Muse, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Biochemical Society symposium.

Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).

G. Milligan, M. Wakelam, C. Unson, 1989, The Biochemical journal.

Merrifield laboratory: Last member standing

C. Unson, 2008, Biopolymers.