J. K. Ghosh

发表

Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics

W. Ng, S. Bhattacharjya, R. P. Dewangan, 2018, ACS omega.

Molecular Dynamics Simulations of the Host Defense Peptide Temporin L and Its Q3K Derivative: An Atomic Level View from Aggregation in Water to Bilayer Perturbation

A. Palleschi, G. Bocchinfuso, L. Stella, 2017, Molecules.

HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation.

Manjeet Kumar, R. Tripathi, J. K. Ghosh, 2019, Life sciences.

Spectroscopic probe of the competitive binding of ethidium bromide and neomycin to DNA

J. K. Ghosh, M. K. Pal, 1995 .

Direct evidence that the N-terminal heptad repeat of Sendai virus fusion protein participates in membrane fusion.

Y. Shai, J. K. Ghosh, 1999, Journal of molecular biology.

Sendai virus internal fusion peptide: structural and functional characterization and a plausible mode of viral entry inhibition.

S. Peisajovich, Y. Shai, J. K. Ghosh, 2000, Biochemistry.

Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2.

S. Srivastava, J. K. Ghosh, B. K. Pandey, 2011, The Biochemical journal.

Involvement of mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) in endothelial dysfunction associated with pulmonary hypertension.

M. Gaestel, Kumaravelu Jagavelu, N. Verma, 2021, Life sciences.

Identification of Potential Inhibitors of Cathepsin‐B using Shape & Pharmacophore‐based Virtual Screening, Molecular Docking and Explicit Water Thermodynamics

M. Siddiqi, D. Banerjee, M. Harioudh, 2020, Molecular informatics.

Dynamics of Physical Interaction between HIV-1 Nef and ASK1: Identifying the Interacting Motif(S)

R. Tripathi, Balawant Kumar, S. Bhadauria, 2013, PloS one.

An MD2-derived peptide promotes LPS aggregation, facilitates its internalization in THP-1 cells, and inhibits LPS-induced pro-inflammatory responses

S. Srivastava, A. Tripathi, M. Harioudh, 2018, Cellular and Molecular Life Sciences.

Modulation of anti-endotoxin property of Temporin L by minor amino acid substitution in identified phenylalanine zipper sequence.

S. Srivastava, A. Tripathi, J. K. Ghosh, 2016, The Biochemical journal.

Introduction of a Lysine Residue Promotes Aggregation of Temporin L in Lipopolysaccharides and Augmentation of Its Antiendotoxin Property

S. Srivastava, J. K. Ghosh, 2013, Antimicrobial Agents and Chemotherapy.

Characterization of antimicrobial, cytotoxic, and antiendotoxin properties of short peptides with different hydrophobic amino acids at "a" and "d" positions of a heptad repeat sequence.

P. Shukla, S. Srivastava, J. K. Ghosh, 2013, Journal of medicinal chemistry.

Lipopolysaccharide Cells and Interaction with Proinflammatory Response in Macrophage Lipopolysaccharide-induced Neutralization of Zipper Sequence of Melittin in Its Consequences of Alteration in Leucine

R. Srivastava, Virendra Kumar, J. K. Ghosh, 2013 .

Aggregation of Temporin L and anti-endotoxin property 1 Introduction of a lysine residue Promotes aggregation of Temporin L in 1 lipopolysaccharides and augmentation of its anti-endotoxin property 2

S. Srivastava, J. K. Ghosh, 2013 .

Consequences of Alteration in Leucine Zipper Sequence of Melittin in Its Neutralization of Lipopolysaccharide-induced Proinflammatory Response in Macrophage Cells and Interaction with Lipopolysaccharide*

S. Srivastava, R. Srivastava, V. K. Bajpai, 2011, The Journal of Biological Chemistry.

Structure-function study of cathelicidin-derived bovine antimicrobial peptide BMAP-28: design of its cell-selective analogs by amino acid substitutions in the heptad repeat sequences.

Aqeel Ahmad, N. Asthana, R. Srivastava, 2009, Biochimica et biophysica acta.

Utilization of an Amphipathic Leucine Zipper Sequence to Design Antibacterial Peptides with Simultaneous Modulation of Toxic Activity against Human Red Blood Cells*

Aqeel Ahmad, N. Asthana, K. Mitra, 2006, Journal of Biological Chemistry.

Cell-selective lysis by novel analogues of melittin against human red blood cells and Escherichia coli.

Aqeel Ahmad, S. Srivastava, N. Asthana, 2010, Biochemistry.

Inhibition of Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 (MK2) is Protective in Pulmonary Hypertension

M. Gaestel, D. Chanda, Kumaravelu Jagavelu, 2021, Hypertension.

Introduction of cell‐selectivity in bovine cathelicidin BMAP‐28 by exchanging heptadic isoleucine with the adjacent proline at a non‐heptadic position

S. Srivastava, N. Verma, J. K. Ghosh, 2020 .

Towards the synthesis of sugar amino acid containing antimicrobial noncytotoxic CAP conjugates with gold nanoparticles and a mechanistic study of cell disruption.

T. Chakraborty, K. Mitra, J. K. Ghosh, 2011, Organic & biomolecular chemistry.

A peptide derived from the putative transmembrane domain in the tail region of E. coli toxin hemolysin E assembles in phospholipid membrane and exhibits lytic activity to human red blood cells: plausible implications in the toxic activity of the protein.

Aqeel Ahmad, N. Asthana, R. Tripathi, 2009, Biochimica et biophysica acta.

Structural and functional changes in a synthetic S5 segment of KvLQT1 channel as a result of a conserved amino acid substitution that occurs in LQT1 syndrome of human.

J. K. Ghosh, Richa Verma, 2010, Biochimica et biophysica acta.

Addition of a small hydrophobic segment from the head region to an amphipathic leucine zipper like motif of E. coli toxin hemolysin E enhances the peptide-induced permeability of zwitterionic lipid vesicles.

Aqeel Ahmad, J. K. Ghosh, S. P. Yadav, 2007, Biochimica et biophysica acta.

Selective cytotoxicity of dermaseptins

Y. Shai, A. Mor, J. K. Ghosh, 1999 .

Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents.

G. Pant, R. P. Dewangan, S. Habib, 2022, Journal of medicinal chemistry.

HIV‐1 Nef hijacks both exocytic and endocytic pathways of host intracellular trafficking through differential regulation of Rab GTPases

S. Buch, P. Dash, R. Tripathi, 2022, Biology of the cell.

HIV-1 Nef CAWLEAQ motif: a regulator of monocytes invasion through ENO1 modulation

Pradeep Kumar, P. Kumar, A. Tripathi, 2018, Molecular and Cellular Biochemistry.

Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms

P. Shukla, Aqeel Ahmad, S. Srivastava, 2014, Amino Acids.

Studies on the assembly of a leucine zipper antibacterial peptide and its analogs onto mammalian cells and bacteria

Aqeel Ahmad, J. K. Ghosh, Sarfuddin Azmi, 2011, Amino Acids.

Phospholipid membrane-interaction of a peptide from S4 segment of KvAP K(+) channel and the influence of the positive charges and an identified heptad repeat in its interaction with a S3 peptide.

J. K. Ghosh, Richa Verma, 2011, Biochimie.

A Synthetic S6 Segment Derived from KvAP Channel Self-assembles, Permeabilizes Lipid Vesicles, and Exhibits Ion Channel Activity in Bilayer Lipid Membrane*

Subhendu Ghosh, S. Srivastava, J. K. Ghosh, 2011, The Journal of Biological Chemistry.

Identification and Characterization of an Amphipathic Leucine Zipper-like Motif in Escherichia coli Toxin Hemolysin E

B. Kundu, J. K. Ghosh, S. P. Yadav, 2003, Journal of Biological Chemistry.

Structure-Function Study of a Heptad Repeat Positioned Near the Transmembrane Domain of Sendai Virus Fusion Protein Which Blocks Virus-Cell Fusion*

S. Peisajovich, Y. Shai, J. K. Ghosh, 1998, The Journal of Biological Chemistry.

Tetrahydrofuran amino acid-containing gramicidin S analogues with improved biological profiles.

T. Chakraborty, R. S. Ampapathi, S. Sinha, 2015, Organic & biomolecular chemistry.

Synthesis and Conformational Studies of Taa‐Containing o‐Nitrobenzenesulfonamide‐ (o‐Nosyl‐) Protected GS Analogs to Prove the Importance of 6R Stereochemistry of Taa over 6S

R. S. Ampapathi, J. K. Ghosh, G. Singh, 2018 .

Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat.

P. Shukla, A. Tripathi, K. Mitra, 2017, Acta biomaterialia.

A Non-cytotoxic Temporin L-Analogue with In Vivo Antibacterial and Anti-endotoxin Activities, and Non-membrane-lytic Mode of Action.

G. Pant, Mehmood Ali, N. Verma, 2020, ACS infectious diseases.

Dissection of Antibacterial and Toxic Activity of Melittin

N. Asthana, J. K. Ghosh, S. P. Yadav, 2004, Journal of Biological Chemistry.

ENERGY TRANSFER FROM THIACYANINE TO ACRIDINE ORANGE FACILITATED BY DNA

A. Mandal, J. K. Ghosh, M. K. Pal, 1999 .

Spermicidal efficacy of VRP, a synthetic cationic antimicrobial peptide, inducing apoptosis and membrane disruption

S. Saha, J. K. Ghosh, Sarfuddin Azmi, 2018, Journal of cellular physiology.

HIV-1 Nef physically associate with CAMKIIδ - ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells.

Pradeep Kumar, A. Nazir, M. Siddiqi, 2019, Life sciences.

A TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice

S. Bhattacharya, M. Siddiqi, K. Mitra, 2018, The Journal of Biological Chemistry.

Induction of a Diverse T Cell Receptor γ/δ Repertoire by the Helix-Loop-Helix Proteins E2a and Heb in Nonlymphoid Cells

C. Murre, W. Romanow, J. K. Ghosh, 2001, The Journal of experimental medicine.

An Unprecedented alteration in mode of action of IsCT resulting its translocation into bacterial cytoplasm and inhibition of macromolecular syntheses

K. Mitra, Manoj Kathuria, J. K. Ghosh, 2015, Scientific Reports.

Selective Cytotoxicity of Dermaseptin S3 toward IntraerythrocyticPlasmodium falciparum and the Underlying Molecular Basis*

Y. Shai, A. Mor, D. Mazier, 1997, The Journal of Biological Chemistry.

A collagen domain–derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms

S. Gautam, A. Srivastava, J. K. Ghosh, 2018, The Journal of Biological Chemistry.

Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.

G. Pant, N. Verma, K. Mitra, 2021, Journal of medicinal chemistry.

Energy transfer and formation of exciplex between thiacyanine and acridine orange facilitated by anionic biopolymers and synthetic polymers

J. K. Ghosh, M. K. Pal, 1994 .

A Peptide Derived from a Conserved Domain of Sendai Virus Fusion Protein Inhibits Virus-Cell Fusion

Y. Shai, J. K. Ghosh, 1998, The Journal of Biological Chemistry.

Circular dichroic and spectrophotometric probes of the competitive binding of crystal violet between DNA and other anionic polymers

J. K. Ghosh, M. K. Pal, 1994 .

10-Residue MyD88-Peptide Adopts β-Sheet Structure, Self-Assembles, Binds to Lipopolysaccharides, and Rescues Mice from Endotoxin-Mediated Lung-Infection and Death.

S. Bhattacharjya, M. Siddiqi, A. Tripathi, 2022, ACS chemical biology.

Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity

A. Tripathi, K. Mitra, Manoj Kathuria, 2016, Antimicrobial Agents and Chemotherapy.

Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities

P. Shukla, M. Mahajan, S. Bhattacharjya, 2017, Scientific Reports.

A leucine zipper motif in the ectodomain of Sendai virus fusion protein assembles in solution and in membranes and specifically binds biologically-active peptides and the virus.

Y. Shai, J. K. Ghosh, M. Ovadia, 1997, Biochemistry.

HIV-1 Nef CAWLEAQ motif: a regulator of monocytes invasion through ENO1 modulation

Pradeep Kumar, A. Tripathi, R. Tripathi, 2018, Molecular and Cellular Biochemistry.

Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application.

N. Chattopadhyay, N. Verma, K. Mitra, 2021, ACS applied materials & interfaces.

Computational design of biologically active anti-cancer peptides and their interactions with heterogeneous POPC/POPS lipid membrane.

Maninder Singh, Durga Prasad Mishra, Mohammad Imran Siddiqi, 2019, Journal of chemical information and modeling.

Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities

P. Shukla, A. Tripathi, K. Mitra, 2017, Scientific Reports.

Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity.

Aqeel Ahmad, S. Srivastava, R. Srivastava, 2009, Biochemistry.

Liquid chromatography–tandem mass spectrometry based method development and validation of S016‐1271 (LR8P), a novel cationic antimicrobial peptide for its application to pharmacokinetic studies

A. Tripathi, N. Verma, Rajesh Pradhan, 2019, Journal of pharmaceutical and biomedical analysis.

Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resistant S. aureus.

R. P. Dewangan, J. K. Ghosh, Rikeshwer Prasad Dewangan, 2023, Bioorganic chemistry.

Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities

A. Tripathi, K. Mitra, Manoj Kathuria, 2017, Scientific Reports.

Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.

J. K. Ghosh, Sariyah Akhtar, D. P. Verma, 2024, Journal of medicinal chemistry.

Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties.

N. Chattopadhyay, K. Mitra, J. K. Ghosh, 2015, Biomaterials.