G. Rachakonda

发表

Cellular Response to Trypanosoma cruzi Infection Induces Secretion of Defensin α-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility, and Inhibits Infection

S. Pratap, P. Nde, M. Lima, 2013, Infection and Immunity.

Cysteine-based regulation of the CUL3 adaptor protein Keap1.

M. Freeman, K. Sekhar, G. Rachakonda, 2010, Toxicology and applied pharmacology.

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.

D. Liebler, M. Freeman, K. Sekhar, 2008, Chemical research in toxicology.

Epitope Capsid-Incorporation: A New Effective Approach for Vaccine Development for Chagas Disease

Shruti S. Sakhare, S. Pratap, P. Nde, 2016, Pathogens & immunity.

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi

Sammed N. Mandape, S. Pratap, P. Nde, 2016, PLoS neglected tropical diseases.

Immunization with Hexon Modified Adenoviral Vectors Integrated with gp83 Epitope Provides Protection against Trypanosoma cruzi Infection

S. Pratap, P. Nde, M. Lima, 2014, PLoS neglected tropical diseases.

Smad7 induces hepatic metastasis in colorectal cancer

N. Deane, S. Halder, P. Datta, 2008, British Journal of Cancer.

Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells

S. Pratap, N. Sheibani, P. Nde, 2022, PLoS neglected tropical diseases.

Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells

S. Pratap, N. Sheibani, P. Nde, 2020, International journal of molecular sciences.

Trypanosoma cruzi Modulates PIWI-Interacting RNA Expression in Primary Human Cardiac Myocytes during the Early Phase of Infection

S. Pratap, P. Nde, M. Lima, 2020, International journal of molecular sciences.

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.

M. Waterman, W. D. Nes, Z. Wawrzak, 2015, The Journal of infectious diseases.

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

Z. Wawrzak, F. Villalta, R. Schotzinger, 2015, Antimicrobial Agents and Chemotherapy.

Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease

M. Washington, D. Smoot, Xuan-Zheng P. Shi, 2021, PloS one.

Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.

M. Freeman, K. Sekhar, Soumya Sasi, 2008, Cancer research.

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.

Anna L. Blobaum, W. D. Nes, M. Botta, 2018, Journal of medicinal chemistry.

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

Z. Wawrzak, E. Garvey, C. M. Yates, 2017, Antimicrobial Agents and Chemotherapy.

Indolyl‐quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation‐mediated control of tumor vasculature

P. Crooks, D. M. Morré, D. Morré, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Anna L. Blobaum, W. D. Nes, C. Lindsley, 2018, Journal of medicinal chemistry.

COVID-19 Incidence and Mortality in Long-Term Care Facilities in Tennessee.

G. Rachakonda, Ariel Worley, Peace Odiase, 2022, International journal of nursing and health care research.

Advances in preclinical approaches to Chagas disease drug discovery

F. Villalta, G. Rachakonda, 2019, Expert opinion on drug discovery.

Application of C-Terminal Clostridium Perfringens Enterotoxin in Treatment of Brain Metastasis from Breast Cancer

G. Rachakonda, A. Garg, S. Adunyah, 2022, Cancers.

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.

F. Villalta, G. Lepesheva, C. Britto, 2019, ACS infectious diseases.

piRNAs as Modulators of Disease Pathogenesis

S. Pratap, P. Nde, M. Lima, 2021, International journal of molecular sciences.

The Novel Chemical Entity YTR107 Inhibits Recruitment of Nucleophosmin to Sites of DNA Damage, Suppressing Repair of DNA Double-Strand Breaks and Enhancing Radiosensitization

P. Crooks, W. McDonald, M. Freeman, 2011, Clinical Cancer Research.

NRF2 deficiency reduces life span of mice administered thoracic irradiation.

M. Freeman, Xinhui Zhou, E. Travis, 2011, Free radical biology & medicine.

Respiratory and Neurological Disease across Different Ethnic Groups Is Influenced by the Microbiome

F. Villalta, G. Rachakonda, Kartik Rachakonda, 2021, Microorganisms.

Increased Cell Migration and Plasticity in Nrf2 Deficient Cancer Cell Lines

J. Wikswo, D. Jowhar, R. Beauchamp, 2010, Oncogene.

Cancer Therapy : Preclinical The Novel Chemical Entity YTR 107 Inhibits Recruitment of Nucleophosmin toSites ofDNADamage , SuppressingRepair of DNA Double-Strand Breaks and Enhancing Radiosensitization

P. Crooks, W. McDonald, M. Freeman, 2011 .

Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase

Sammed N. Mandape, Shruti S. Sakhare, S. Pratap, 2018, PLoS neglected tropical diseases.

Xanthine Analogs Suppress Trypanosoma cruzi Infection In Vitro Using PDEs as Targets

P. Nde, M. Lima, F. Villalta, 2022, Microbiology Research.

Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition.

Z. Wawrzak, F. Guengerich, F. Villalta, 2021, Journal of medicinal chemistry.

Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer.

Debangshu Samanta, P. Datta, G. Rachakonda, 2016, Cellular signalling.

Genetic diversity of noroviruses and sapoviruses in children with acute sporadic gastroenteritis in New Delhi, India.

S. Parveen, S. Bhatnagar, S. Broor, 2008, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

M. Waterman, Z. Wawrzak, F. Villalta, 2014, Journal of medicinal chemistry.

The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins

Alex J. Walsh, P. Crooks, D. Friedman, 2013, Investigational New Drugs.