Y. Rew

发表

Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

Dongwoo Shin, Dale L Boger, D. Boger, 2007, Journal of the American Chemical Society.

Functional and biochemical analysis of a key series of ramoplanin analogues.

D. Boger, S. Walker, Dongwoo Shin, 2009, Bioorganic & medicinal chemistry letters.

Ordering of the N-terminus of human MDM2 by small molecule inhibitors.

L. Poppe, J. B. Jordan, P. Schnier, 2012, Journal of the American Chemical Society.

Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics.

D. Boger, S. Walker, Dongwoo Shin, 2004, Journal of the American Chemical Society.

Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity.

D. Boger, S. Walker, Dongwoo Shin, 2005, Chemical reviews.

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).

N. Jahchan, E. Jackson, J. Medina, 2018, Journal of medicinal chemistry.

T. Yaksh, M. Goodman, J. Taulane, 2006, PAIN.

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.

J. Oliner, S. Olson, Q. Ye, 2011, Bioorganic & medicinal chemistry letters.

Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Chemistry and Biology of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic Activity

D. Boger, S. Walker, Dongwoo Shin, 2005 .

Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex.

D. Boger, Dongwoo Shin, Y. Rew, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological activities of cyclic lanthionine enkephalin analogues : δ-opioid receptor selective ligands

C. Svensson, T. Yaksh, P. Schiller, 2002 .

Synthesis and biologic activity of conformationally constrained analogs of L-363,301.

M. Fabbri, M. Goodman, Y. Rew, 2008, The journal of peptide research : official journal of the American Peptide Society.

Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.

Sean P. Brown, A. Cheng, D. Whittington, 2019, Journal of medicinal chemistry.

Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).

N. Jahchan, J. Medina, V. Fantin, 2019, Journal of medicinal chemistry.

Systemic and Spinal Analgesic Activity of a δ-Opioid-Selective Lanthionine Enkephalin Analog

C. Svensson, T. Yaksh, P. Schiller, 2003, Journal of Pharmacology and Experimental Therapeutics.

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Y. Wang, J. Canon, J. Oliner, 2014, Journal of medicinal chemistry.

New reagents, reactions, and peptidomimetics for drug design.

M. Goodman, M Goodman, Y. Rew, 2002, Biopolymers.

An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters

R. Hungate, J. Powers, D. McMinn, 2007 .

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Xin Huang, Paul Shaffer, Steve Schneider, 2013, Journal of medicinal chemistry.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

J. Canon, J. Oliner, Xin Huang, 2014, Journal of medicinal chemistry.

Abstract 4172: Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide response

Mallika Singh, E. Jackson, J. Medina, 2017 .

Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer.

Daqing Sun, Y. Rew, 2014, Journal of medicinal chemistry.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

M. Monshouwer, N. Walker, R. Hungate, 2008, Journal of medicinal chemistry.

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.

Xin Huang, Paul Shaffer, Daqing Sun, 2014, ACS medicinal chemistry letters.

Synthesis, in Vitro Covalent Binding Evaluation, and Metabolism of (14)C-Labeled Inhibitors of 11β-HSD1.

M. Monshouwer, Min Jiang, J. Powers, 2014, ACS medicinal chemistry letters.

Novel reagents and reactions for drug design

T. J. Baker, Y. Rew, M. Goodman, 2000 .

Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog.

C. Svensson, T. Yaksh, P. Schiller, 2003, The Journal of pharmacology and experimental therapeutics.

T. Yaksh, M. Goodman, J. Taulane, 2006, Pain.

Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.

J. Jaén, J. Powers, D. McMinn, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.

N. Walker, R. Hungate, Zhulun Wang, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of cyclic lanthionine enkephalin analogues : δ-opioid receptor selective ligands

C. Svensson, T. Yaksh, P. Schiller, 2002 .