T. Leisner

发表

Bioactive Ether Lipids: Primordial Modulators of Cellular Signaling

S. Holly, Nikhil Rangholia, T. Leisner, 2021, Metabolites.

Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

L. Parise, A. Kabanov, E. Batrakova, 2019, Advanced science.

Discovery and Characterization of Peptide Inhibitors for CIB1.

S. Frye, K. Pearce, L. Parise, 2020, ACS chemical biology.

CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling

S. Holly, L. Parise, T. Leisner, 2012, Oncogene.

Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3.

S. Lam, T. Leisner, I. Knezevic, 1996, The Journal of biological chemistry.

Tickling the tails: cytoplasmic domain proteins that regulate integrin αIIbβ3 activation

Weiping Yuan, L. Parise, Jan C. DeNofrio, 2007 .

Identification of novel integrin binding partners for CIB1: structural and thermodynamic basis of CIB1 promiscuity

Justin L. Black, N. Dokholyan, Yi I. Wu, 2014 .

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation

Weiping Yuan, L. Parise, S. Lam, 2006, The Journal of cell biology.

integrin αIIbβ3 activation

Weiping Yuan, L. Parise, M. Larson, 2006 .

Discovery and Development of Cyclic Peptide Inhibitors of CIB1.

Xian Chen, Ling Xie, K. Pearce, 2021, ACS medicinal chemistry letters.

CIB1 Is Essential for Mouse Spermatogenesis

D. A. O’Brien, N. Maeda, Weiping Yuan, 2006, Molecular and Cellular Biology.

Machine Learning to Quantitate Neutrophil NETosis

Ioannis M. Rekleitis, Ioannis Rekleitis, Md. Modasshir, 2019, Scientific Reports.

Platelet α2β1 integrin activation: contribution of ligand internalization and the α2-cytoplasmic domain

L. Parise, T. Leisner, Zhengyan Wang, 2003 .

CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer

Nicole M. Baker, Justin L. Black, C. Perou, 2015, Breast Cancer Research and Treatment.

Platelet alpha2beta1 integrin activation: contribution of ligand internalization and the alpha2-cytoplasmic domain.

L. Parise, T. Leisner, Zhengyan Wang, 2003, Blood.

CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis

J. Faber, Weiping Yuan, L. Parise, 2007, Circulation research.

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1

S. Frye, K. Pearce, L. Parise, 2020 .

The human CIB1–EVER1–EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses

J. Casanova, E. Fuchs, J. Franco, 2018, The Journal of experimental medicine.

Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.

Ling Lin, S. Holly, L. Parise, 2019, Blood advances.

CIB1: a small protein with big ambitions

Justin L. Black, L. Parise, T. Freeman, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Direct Binding of the Platelet Integrin αIIbβ3 (GPIIb-IIIa) to Talin

Tina M. Leisner, S. Lam, T. Leisner, 1996, The Journal of Biological Chemistry.

Essential role of CIB1 in regulating PAK1 activation and cell migration

J. Chernoff, L. Parise, T. Leisner, 2005, The Journal of cell biology.

Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.

Justin L. Black, Yi I. Wu, N. Dokholyan, 2013, Biochemistry.

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer’s disease

A. Levey, S. Frye, K. Pearce, 2023, bioRxiv.

Bidirectional Transmembrane Modulation of Integrin αIIbβ3 Conformations*

S. Lam, T. Leisner, Wei Wang, 1999, The Journal of Biological Chemistry.

CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death

L. Parise, Alexander H. Chung, T. Leisner, 2019, Cancer Cell International.

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Jessica E. Young, K. Pearce, A. Axtman, 2023, bioRxiv.

Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display.

K. Pearce, C. Vaziri, T. Leisner, 2023, Journal of the American Chemical Society.

Talin's second act-ivation: retraction.

L. Parise, T. Leisner, 2011, Blood.

Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot

K. Pearce, D. Kireev, T. Leisner, 2023, Research square.

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

T. Willson, A. Wingo, N. Seyfried, 2023, The Journal of biological chemistry.

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

M. Heise, Sumera Perveen, D. Streblow, 2024, bioRxiv.